Function and Modulation of Sphingosine-1-Phosphate Receptors in the Central Nervous System
ReceptorsSphingolipids, first discovered in 1874 by Johann Thudicum, are among the eight recognized classes of lipids and are present in essentially all plants, animals, and fungi, as well as some viruses and prokaryotes. In mammals, sphingolipids are enriched in
Elizabeth Gulliksen +7 more
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Investigations of the lysophospholipid composition of human neutrophils under different stimulation conditions by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [PDF]
Journal of the Serbian Chemical Society, 2002 Matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF MS) is usually used for the analyses of proteins, carbohydrates and oligonucleotides.
JURGEN ARNHOLD +4 more
doaj
Phosphorus Deficiency Alters Nutrient Accumulation Patterns and Grain Nutritional Quality in Rice
Agronomy, 2016 The accumulation of biomass and mineral nutrients during the post-anthesis period was investigated in field-grown rice plants cultivated in phosphorus (P)-sufficient vs. P-deficient soil.
Terry J. Rose +4 more
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Journal of Diabetes, Volume 18, Issue 5, May 2026.This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li +5 more
wiley +1 more source
What have we learned from two-pore potassium channels? Their molecular configuration and function in the human heart [PDF]
, 2012 Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Benyhe, Sándor +11 more
core
Daily rhythms of glycerophospholipid synthesis in fibroblast cultures involve differential enzyme contributions [PDF]
, 2013 Circadian clocks regulate the temporal organization of several biochemical processes including lipid metabolism and their disruption leads to severe metabolic disorders. Immortalized cell lines acting as circadian clocks display daily variations in [32P]-
Acosta Rodríguez, Victoria América +7 more
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Addiction Biology, Volume 31, Issue 5, May 2026.In this responder‐enriched lipidomic substudy, response to long‐acting naltrexone in alcohol use disorder was associated with coordinated remodelling of plasma membrane phospholipids. The signature involved PEMT‐related PC/PE shifts, Lands‐cycle acyl chain editing, and cross‐headgroup redistribution of n‐3 PUFAs and arachidonic acid, defining a ...
Liyao Huang +5 more
wiley +1 more source
Lipids of mineralizing epiphyseal tissues in the bovine fetus
Journal of Lipid Research, 1968 Because lipids had been consistently detected histologically at sites of new calcification, the lipids of epiphyseal cartilage and bone in various stages of mineralization were examined.
R.E. Wuthier
doaj +1 more source
Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]
, 2016 NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E +2 more
core +2 more sources
GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator [PDF]
, 2023 Keisuke Kitakaze +9 more
openalex +1 more source