Results 81 to 90 of about 18,174 (203)
MetabolitesChronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by persistent respiratory symptoms and airflow limitation. While there are some available treatment options, the effectiveness of treatment varies depending on ...
Qiqiang Zhou +3 more
doaj +1 more source
Biomedicines, 2020 It is widely accepted that microglia-mediated inflammation contributes to the progression of neurodegenerative diseases; however, the precise mechanisms through which these cells contribute remain to be elucidated.
Tamotsu Tsukahara +3 more
doaj +1 more source
The FEBS Journal, EarlyView.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
Patatin-Related Phospholipase pPLAIIIγ Involved in Osmotic and Salt Tolerance in Arabidopsis
Plants, 2020 Patatin-related phospholipases (pPLAs) are acyl-hydrolyzing enzymes implicated in various processes, including lipid metabolism, signal transduction, plant growth and stress responses, but the function for many specific pPLAs in plants remains unknown ...
Jianwu Li +4 more
doaj +1 more source
Lysophospholipid G Protein-coupled Receptors [PDF]
Journal of Biological Chemistry, 2004 The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
openaire +2 more sources
MedComm, Volume 7, Issue 4, April 2026.This study identified 10 potential causality between metabolites and blood pressure and found potential genetic regulators of two metabolites. Multiomics integration revealed that a genetic variant near the omega‐3 metabolism genes (FADS1/FADS2) may influence blood pressure regulation by modulating prostaglandin E3 levels.
Yuanjiao Liu +5 more
wiley +1 more source
Function and Modulation of Sphingosine-1-Phosphate Receptors in the Central Nervous System
ReceptorsSphingolipids, first discovered in 1874 by Johann Thudicum, are among the eight recognized classes of lipids and are present in essentially all plants, animals, and fungi, as well as some viruses and prokaryotes. In mammals, sphingolipids are enriched in
Elizabeth Gulliksen +7 more
doaj +1 more source
Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]
, 2020 Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui +3 more
core +2 more sources
Aging Cell, Volume 25, Issue 4, April 2026.Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Amelie Prier +10 more
wiley +1 more source
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? [PDF]
, 2013 Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell ...
Doñate-Macian, Pau +2 more
core +1 more source