Results 121 to 130 of about 30,858,840 (226)

Correlation of peripheral PLA2R antibody， VASH-1， and Beclin-1 with disease severity and prognosis in primary membranous nephropathy

Linchuang shenzangbing zazhi
ObjectiveTo investigate the relationships between peripheral blood phospholipase A2 receptor （PLA2R） antibody， vasohibin-1 （VASH-1）， and autophagy-related protein Beclin-1 and the clinical condition and prognosis of patients with primary membranous ...
Guo Xiao-yang, Zhao Mi-xia, Ren Hai-qing
doaj  

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report

BMC Nephrology
Background The concomitant occurrence of membranous nephropathy and anti-glomerular basement (anti-GBM) disease has been previously described but is extremely rare.
Ge Liu, Xinyan Feng, Shuangyan Yu, Jie Sheng, Chunyan Liu, Lihua Wang   +5 more
doaj   +1 more source

A Case Report of Lupus Nephritis Initially Presenting As Membranous Nephropathy Treated With Sequential Obinutuzumab and Belimumab

Xiehe Yixue Zazhi
This article reports a case of an elderly male patient presenting with nephrotic syndrome. Renal biopsy pathology indicated membranous nephropathy, with both renal tissue staining for M-type phospholipase A2 receptor (PLA2R) and serum anti-PLA2R ...
LEI Xin, SHI Nan, LANG Xiabing, HUANG Xiaohan, HAN Fei   +4 more
doaj   +1 more source

Deciphering Host Genomic Pathway Landscapes in Severe COVID‐19 by Exome Sequencing of a Large Admixed Brazilian Cohort

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The host genetic factors that resulted in the heterogeneous clinical outcomes of COVID‐19 remained poorly understood, especially in admixed populations that are underrepresented in global genomic studies. In this study, we investigated the genetic landscape associated with COVID‐19 severity using whole‐exome sequencing data from 325 Brazilian ...
Aléxia Stefani Siqueira Zetum, Danielle Ribeiro Campos da Silva, Vinícius do Prado Ventorim, Felipe Ataides Mion, Felipe dos Santos Passarela, Patrícia Brasil, Túlio de Lima Campos, Bartolomeu Acioli‐Santos, Flávio Rosendo da Silva Oliveira, Raquel Silva dos Reis Trabach, Lorena Souza Castro Altoé, Débora Dummer Meira, Iúri Drumond Louro   +12 more
wiley   +1 more source

Carbodiimide modification enhances activity of pig pancreatic phospholipase A2

, 1994
Pig phospholipase A2, pig iso-phospholipase A2 and bovine pancreatic phospholipase A2 were reacted in solution with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, in the presence of N-hydroxysulfosuccinimide, at pH 7.
Louie, Otway, Ferreira, João Paulo M., Sasisekharan, Ram, Langer, Robert   +3 more
core   +1 more source

Evolution of idiopathic membranous nephropathy to class v lupus nephritis: a case report and literature review

Frontiers in Medicine
BackgroundThe M-type phospholipase A2 receptor (PLA2R) antibody positivity is considered a specific serological marker for idiopathic membranous nephropathy (IMN), and its presence in class V lupus nephritis (LN) is rare.
Bo Shen, Cheng Peng, Weicheng Xiao
doaj   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Phase 1 Study of Safety and PK With A Combination of Omeprazole and Trimetazidine for Fatty Acid Oxidation Inhibition in Patients With Advanced Solid Tumors

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Fatty acid oxidation (FAO) is a metabolic vulnerability in cancer cells, making pharmacologic FAO inhibition a promising therapeutic strategy. This Phase I, open‐label, 3 + 3 dose‐escalation study evaluated the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of two oral FAO inhibitors—omeprazole (KN510), a carnitine ...
Wonyoung Choi, Jung W. Chun, Sung H. Sim, Sung‐Sik Han, Woo J. Lee, Joon H. Kang, Hyun Chul Kim, SeungHwan Lee, Jun H. Lee, Hyun J. Yoo, Soo‐Youl Kim, Sang M. Woo   +11 more
wiley   +1 more source