Results 131 to 140 of about 26,727 (247)
Frontiers in MedicineBackgroundThe M-type phospholipase A2 receptor (PLA2R) antibody positivity is considered a specific serological marker for idiopathic membranous nephropathy (IMN), and its presence in class V lupus nephritis (LN) is rare.
Bo Shen, Cheng Peng, Weicheng Xiao
doaj +1 more source
Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais +5 more
wiley +1 more source
Study of the cell biological role of Lowe Syndrome protein OCRL1
, 2009 Oculocerebrorenal syndrome of Lowe (OCRL) is caused by mutations in a phosphatidylinositol 5-phosphatase, OCRL1, and is believed to lead to an elevation of its preferred substrate, PI(4,5)P2.
Grieve, A.G.
core
Phospholipase A2 Receptor and α-enolase in the Immunodiagnosis of membranous nephropathy
, 2015 M-type phospholipase A2 receptor (PLA2R) and α-enolase are two recently identified autoantigens in adult idiopathic membranous nephropathy (IMN). To identify their diagnostic value and the potential roles in the pathogenesis of MN, renal biopsies and ...
Zhang, Ying
core +1 more source
Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Differential diagnosis of membranous nephropathy with autoantibodies to phospholipase A2 receptor 1
, 2014 Membranous nephropathy (MN) accounts for most cases of the nephrotic syndrome in adults. Recently, studies on the underlying pathomechanisms led to the identification of the podocyte M-type receptor for secretory phospholipase A2 (PLA2R1) as a target ...
Lange, Sascha +7 more
core +1 more source
Advanced Science, Volume 13, Issue 32, 9 June 2026.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
The Emerging Parkinson's Disease Oxylipin‐Ome
Advanced Science, Volume 13, Issue 33, 15 June 2026.ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley +1 more source
Activation of phospholipase A2 by cannabinoids Lack of correlation with CNS effects
, 1987 Cannabinoids Δ1-tetrahydrocannabinol, cannabinol, cannabidiol and cannabigerol have been shown to affect directly the activity of phospholipase A2 in a cell-free assay.
Evans, A.T. +5 more
core +1 more source