WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis [PDF]
Advanced ScienceN1‐methyladenosine (m1A) modification widely occurs in various RNAs, yet its pathophysiological function in tumorigenesis remains poorly understood. Notably, the expression and biological roles of tRNA m1A methyltransferase 6 noncatalytic subunit (TRMT6)
Yuqing Lei +12 more
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tRNA m1A modification regulate HSC maintenance and self-renewal via mTORC1 signaling. [PDF]
Nat CommunAbstractHaematopoietic stem cells (HSCs) possess unique physiological adaptations to sustain blood cell production and cope with stress responses throughout life. To maintain these adaptations, HSCs rely on maintaining a tightly controlled protein translation rate.
Zuo H, Wu A, Wang M, Hong L, Wang H.
europepmc +4 more sources
tRNA-m1A modification: a translational checkpoint for T cell expansion. [PDF]
Cell Res, 2023 Pei W, Kuchroo VK.
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De-succinylation-induced accumulation of TRMT10C in the nucleus plays a detrimental role in coronary microembolization via its m1A modification function. [PDF]
Int J Biol SciCoronary microembolization (CME) refers to embolism in the coronary microcirculation. This study showed a reduction in succinyl transferase (CPT1A) and the succinylation substrate (succinyl-CoA) in cardiomyocytes in CME models, suppressing the succinylation of the mitochondrially localized protein TRMT10C.
Hu CK +7 more
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The role of m5C, m1A and m7G modifications in tumors of urinary system. [PDF]
Front Cell Dev BiolMalignant tumors of the urinary system, such as kidney cancer, bladder cancer, and prostate cancer, remain a significant challenge despite the various treatment options available. Identifying therapeutic targets for urological tumors is crucial due to the potential for recurrence and metastasis.
Xue W +5 more
europepmc +4 more sources
Identification and validation of an m1A-score model to predict outcomes and immunomodulation in lung squamous cell carcinoma by integrated analysis of single-cell and bulk RNA sequencing [PDF]
Discover OncologyLung squamous cell carcinoma (LUSC) is a common and aggressive subtype of lung cancer, characterized by difficult treatment and poor prognosis. N1-methyladenosine (m1A) is an RNA modification that plays a crucial role in various biological processes ...
Han Gong +5 more
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The m1A modification of tRNAs: a translational accelerator of T-cell activation. [PDF]
Cell Mol Immunol, 2022 Chen C, Ye L.
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Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li +13 more
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Genetic variants of m1A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study [PDF]
Human GenomicsBackground The N1-adenosine methylation (m1A) modification plays a significant role in various cancers. However, the functions of m1A modification genes and their variants in neuroblastoma remain to be elucidated.
Jiaming Chang +9 more
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HeliyonN1-methyladenosine (m1A) modification is a crucial post-transcriptional regulatory mechanism of messenger RNA (mRNA) in living organisms. Few studies have focused on analysis of m1A regulators in lower-grade gliomas (LGG).
Kunjian Lei +16 more
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