Results 11 to 20 of about 755,261 (255)

Branched-chain amino acid catabolism promotes M2 macrophage polarization [PDF]

Frontiers in Immunology
IntroductionDuring an immune response, macrophages undergo systematic metabolic rewiring tailored to support their functions. Branched-chain amino acid (BCAA) metabolism has been reported to modulate macrophage function; however, its role in macrophage ...
Manxi Lu, Da Luo, Zixuan Zhang, Feng Ouyang, Yihong Shi, Changyong Hu, Hang Su, Yining Li, Jiayi Zhang, Qian Gui, Tian-Shu Yang, Tian-Shu Yang, Tian-Shu Yang   +12 more
doaj   +2 more sources

Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo. [PDF]

PLoS ONE, 2014
Although it is well-established that the macrophage M1 to M2 transition plays a role in tumor progression, the molecular basis for this process remains incompletely understood.
Shweta Joshi, Alok R Singh, Muamera Zulcic, Lei Bao, Karen Messer, Trey Ideker, Janusz Dutkowski, Donald L Durden   +7 more
doaj   +2 more sources

SERPINB10 promotes macrophage M2 polarization and airway inflammation in asthma

Respiratory Research
Background Macrophage M2 polarization plays a critical role in type 2 airway inflammation in asthma. We previously reported that serine peptidase inhibitor, clade B, member 10 (SERPINB10) promotes airway eosinophilic inflammation in asthma.
Lu Zhao, Wenliang Wu, Gongqi Chen, Chunli Huang, Weiqiang Kong, Wei Gu, Huiru Jie, Lingling Yi, Guohua Zhen   +8 more
doaj   +2 more sources

M2 Macrophage-Derived Extracellular Vesicles Encapsulated in Hyaluronic Acid Alleviate Osteoarthritis by Modulating Macrophage Polarization

An imbalance between M1 and M2 macrophage polarization is critical in osteoarthritis (OA) development. We investigated the effect of M2 macrophage-derived extracellular vesicles (M2-EVs) to reprogramme macrophages from the M1 to M2 phenotype for OA ...
Haishi Zheng (11894075), Peng Xu (17962), Yongsong Cai (4624093), Qiling Yuan (6793994), Mingyi Yang (11894078), Pan Luo (1455157), Xinyi Wang (559030)   +6 more
core   +7 more sources

Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation [PDF]

, 2010
Classical macrophage activation is inhibited by the CD200 receptor (CD200R). Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-
Brouwer, Michael S. M., Huitinga, I., Voehringer, David, Raes, G., van Eijk, Marco, Hoek, Robert M., Hamann, J., Huitinga, Inge, Koning, N., Brouwer, M.S., Raes, Geert, Pouwels, W., Voehringer, D., Koning, Nathalie, Van Eijk, M., Hoek, R.M., Pouwels, Walter, Hamann, Jörg   +17 more
core   +1 more source

Endogenous Epoxygenases Are Modulators of Monocyte/Macrophage Activity [PDF]

, 2011
Background: Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP450 epoxygenases in monocyte/macrophage-mediated ...
Bishop-Bailey, D, Mary C Sugden, David Bishop-Bailey, Bystrom, J, Holness Mark J., Sugden, MC, Mark J Holness, Holness, MJ, Jessica A. Wray, Wray, JA, Sugden, M C, Matthew L. Edin, Zeldin Darryl C., Zeldin, DC, Karen E Swales, Edin Matthew L., Edin, ML, Zeldin, D C, Sugden Mary C., Wray, J A, Gilroy Derek W., Swales Karen E., Darryl C Zeldin, Gilroy, DW, Derek W Gilroy, Karen E. Swales, Edin, M L, Mark J. Holness, Matthew L Edin, Derek W. Gilroy, Wray Jessica A., Gilroy, D W, Warner Timothy D., Jonas Bystrom, Warner, T D, Darryl C. Zeldin, Timothy D. Warner, Bishop-Bailey David, Bystrom Jonas, Holness, M J, Jessica A Wray, Swales, K E, Warner, TD, Timothy D Warner, Swales, KE, Mary C. Sugden   +45 more
core   +1 more source

Stimulation of the farnesoid X receptor promotes M2 macrophage polarization [PDF]

, 2023
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
ジャローンウイッチャワン, サラント, 80632645, Tsukumo, Shin-ichi, 60214/profile-ja.html, 50454757, コンドウ, ヒロユキ, 30333511, 571, Arimochi, Hideki, 246763/profile-ja.html, Sasaki, Yuki, 1556, Otsuka, Kunihiro, 60092/profile-ja.html, 676, イシフネ, チエコ, 954, Kondo, Hiroyuki, 佐々木, 由紀, オオツカ, クニヒロ, Jaroonwitchawan, Thiranut, 371775/profile-ja.html, 1616, Ishifune, Chieko, 10346596, 近藤, 博之, ヤストモ, コウジ, ツクモ, シンイチ, 有持, 秀喜, 350186/profile-ja.html, Yasutomo, Koji, 九十九, 伸一, 60033/profile-ja.html, 1192, ササキ, ユキ, 大塚, 邦紘, 1521, 30311822, 石舟, 智恵子, アリモチ, ヒデキ, 273670/profile-ja.html, 安友, 康二   +41 more
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Defects in Macrophage Reprogramming in Cancer Therapy: The Negative Impact of PD-L1/PD-1

Frontiers in Immunology, 2021
Classically activated M1 macrophages and alternatively activated M2 macrophages are two polarized subsets of macrophages at the extreme ends of a constructed continuum.
Hao Cai, Yichi Zhang, Jian Wang, Jinyang Gu   +3 more
doaj   +1 more source

Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Macrophages play pivotal roles in host defense and immune homeostasis, which have two major functional polarization states, the classically activated M1 and the alternatively activated M2.
Chao Yuan, Dandan Yang, Jia Ma, Jiali Yang, Jing Xue, Fuyang Song, Xiaoming Liu   +6 more
doaj   +1 more source

Mesenchymal Stem/Stromal Cells Derived from Cervical Cancer Promote M2 Macrophage Polarization

Cells, 2023
Macrophages with the M2 phenotype promote tumor development through the immunosuppression of antitumor immunity. We previously demonstrated the presence of mesenchymal stem/stromal cells (MSCs) in cervical cancer (CeCa-MSCs), suggesting an immune ...
Víctor Adrián Cortés-Morales, Luis Chávez-Sánchez, Leticia Rocha-Zavaleta, Sandra Espíndola-Garibay, Alberto Monroy-García, Marta Elena Castro-Manrreza, Guadalupe Rosario Fajardo-Orduña, Teresa Apresa-García, Marcos Gutiérrez-de la Barrera, Héctor Mayani, Juan José Montesinos   +10 more
doaj   +1 more source