Results 91 to 100 of about 26,139 (253)

Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation [PDF]

Cell, 2017
N6-methyladenosine (m6A), installed by the Mettl3/Mettl14 methyltransferase complex, is the most prevalent internal mRNA modification. Whether m6A regulates mammalian brain development is unknown. Here, we show that m6A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis
Ki-Jun, Yoon, Francisca Rojas, Ringeling, Caroline, Vissers, Fadi, Jacob, Michael, Pokrass, Dennisse, Jimenez-Cyrus, Yijing, Su, Nam-Shik, Kim, Yunhua, Zhu, Lily, Zheng, Sunghan, Kim, Xinyuan, Wang, Louis C, Doré, Peng, Jin, Sergi, Regot, Xiaoxi, Zhuang, Stefan, Canzar, Chuan, He, Guo-Li, Ming, Hongjun, Song   +19 more
openaire   +2 more sources

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Immune Infiltration of Ulcerative Colitis and Detection of the m6A Subtype

Journal of Immunology Research, 2022
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by persistent colon inflammation. N6-methyladenosine (m6A) methylation is one of the most prevalent RNA modifications with key roles in both normal and illness, but m6A methylation in
Chenzheng Gu, Junlu Wu, Wei Zhang, Yiwen Yao, Wenhui Yan, Yi Yuan, Weiwei Wang, Anquan Shang   +7 more
doaj   +1 more source

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation

Frontiers in Oncology, 2021
N6-methyladenosine (m6A) is a common transcriptomic modification in cancer. Recently, it has been found to be involved in the regulation of non-small cell lung cancer (NSCLC) formation and metastasis.
Xiaofeng Mu, Xiaofeng Mu, Qi Zhao, Wen Chen, Yuxiang Zhao, Yuxiang Zhao, Qing Yan, Rui Peng, Jie Zhu, Chunrui Yang, Ketao Lan, Xiaosong Gu, Ye Wang   +12 more
doaj   +1 more source

Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168 [PDF]

, 2016
Phase-variable restriction-modification systems are a feature of a diverse range of bacterial species. Stochastic, reversible switches in expression of the methyltransferase produces variation in methylation of specific sequences.
Awais Anjum, Benjamini, Bickle, Bujnicki, Christopher D. Bayliss, Gaskin, Ian Connerton, Jack Aidley, Julian Parkhill, Kelly J. Brathwaite, Mou, Nicola J. Cummings, Pei, Phillippa L. Connerton   +13 more
core   +2 more sources

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line. [PDF]

, 2017
Plasmodium knowlesi, a common parasite of macaques, is recognised as a significant cause of human malaria in Malaysia. The P. knowlesi A1H1 line has been adapted to continuous culture in human erythrocytes, successfully providing an in vitro model to ...
Benavente, Ernest Diez, Blackman, Michael J, Campino, Susana, Clark, Taane G, de Sessions, Paola Florez, Drakeley, Christopher J, Grainger, Munira, Hibberd, Martin L, Holder, Anthony A, Moon, Robert W, Pain, Arnab, Roper, Cally, Sutherland, Colin J   +12 more
core   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, EarlyView.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source