Analyzing machupo virus-receptor binding by molecular dynamics simulations [PDF]
PeerJ, 2014 In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein–protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Austin G. Meyer +3 more
doaj +11 more sources
Structure of Machupo virus polymerase in complex with matrix protein Z [PDF]
Nature Communications, 2021 The RNA polymerase L of arenaviruses is of interest for drug design and its activity is inhibited by the matrix protein Z. Here, the authors present the cryo-EM structure of the Machupo virus polymerase L in complex with matrix protein Z and discuss the ...
Jun Ma, Shuangyue Zhang, Xinzheng Zhang
doaj +6 more sources
Simultaneous screening for selective SARS-CoV-2, Lassa, and Machupo virus entry inhibitors [PDF]
SLAS DiscoveryEmerging highly pathogenic viruses can pose profound impacts on global health, the economy, and society. To meet that challenge, the National Institute of Allergy and Infectious Diseases (NIAID) established nine Antiviral Drug Discovery (AViDD) centers ...
Yuka Otsuka +9 more
doaj +5 more sources
A STAT-1 knockout mouse model for Machupo virus pathogenesis [PDF]
Virology Journal, 2011 Background Machupo virus (MACV), a member of the Arenaviridae, causes Bolivian hemorrhagic fever, with ~20% lethality in humans. The pathogenesis of MACV infection is poorly understood, and there are no clinically proven treatments for disease.
Shurtleff Amy C +3 more
doaj +6 more sources
Description and characterization of a novel live-attenuated tri-segmented Machupo virus in Guinea pigs [PDF]
Virology Journal, 2018 Background Machupo virus (MACV) is a member of the Mammarenavirus genus, Arenaviridae family and is the etiologic agent of Bolivian hemorrhagic fever, which causes small outbreaks or sporadic cases. Several other arenaviruses in South America Junín virus
Amélie D. Zaza +2 more
doaj +6 more sources
An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection [PDF]
Scientific Reports, 2017 Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car91 that was attenuated in guinea pigs.
Joseph W. Golden +6 more
doaj +7 more sources
Immunoinformatics Approach to Design Multi-Epitope-Based Vaccine against Machupo Virus Taking Viral Nucleocapsid as a Potential Candidate [PDF]
Vaccines, 2022 The family members of Arenaviridae include members of the genus Machupo virus, which have bi-segmented negative sense RNA inside the envelope and can be transferred to humans through rodent carriers.
Muhammad Naveed +9 more
doaj +3 more sources
Machupo virus glycoprotein determinants for human transferrin receptor 1 binding and cell entry. [PDF]
PLoS ONE, 2011 Machupo virus (MACV) is a highly pathogenic New World arenavirus that causes hemorrhagic fever in humans. MACV, as well as other pathogenic New World arenaviruses, enter cells after their GP1 attachment glycoprotein binds to their cellular receptor ...
Sheli R Radoshitzky +8 more
doaj +6 more sources
Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus. [PDF]
J Virol, 2021 Arenaviruses are rodent-borne pathogens that can cause severe disease in humans. All arenaviruses begin the infection cycle with delivery of the virus replication machinery into the cytoplasm of the host cell.
Pyle JD, Whelan SPJ.
europepmc +5 more sources
Glycoprotein-Specific Polyclonal Antibodies Targeting Machupo Virus Protect Guinea Pigs against Lethal Infection [PDF]
VaccinesConvalescent plasma has been shown to be effective at protecting humans against severe diseases caused by New World (NW) arenaviruses, including Junin virus (JUNV) and Machupo virus (MACV).
Joseph W. Golden +2 more
doaj +4 more sources