Results 91 to 100 of about 1,703 (147)
Machupo virus with mutations in the transmembrane domain and glycosylation sites is attenuated and immunogenic in animal models of Bolivian Hemorrhagic Fever [PDF]
, 2021 Emily Mantlo +8 more
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Experimental Biology and Medicine, 1969 SummaryMultiplication of Machupo virus, the etiological agent of Bolivian hemorrhagic fever, was studied in a variety of cell cultures. One line of African green monkey kidney cells (Vero) supported the multiplication of the virus to high titer, but developed no cytopathic effect.
J S, Rhim, B, Simizu, N H, Wiebenga
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The Curious Case of Arenavirus Entry, and Its Inhibition
Viruses, 2012 Arenaviruses comprise a diverse family of enveloped negative-strand RNA viruses that are endemic to specific rodent hosts worldwide. Several arenaviruses cause severe hemorrhagic fevers in humans, including JunÃn and Machupo viruses in South America and ...
Joanne York, Jack H. Nunberg
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[Sedimentation analysis of the virion RNA of Machupo virus].
Voprosy virusologii, 1983 Pichinde and Machupo viruses labeled with 3H-uridine were concentrated and purified by different methods. The buoyant density of the viruses was for Pichinde 1.14-1.15 g/cm3 (urographimeter), 1.19 g/cm3 (sucrose), 1.25 g/cm3 (cesium chloride), for Machupo virus 1.25 g/cm3 (cesium chloride).
I S, Lukashevich +4 more
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Pathogens, 2015 Arenaviruses include multiple human pathogens ranging from the low-risk lymphocytic choriomeningitis virus (LCMV) to highly virulent hemorrhagic fever (HF) causing viruses such as Lassa (LASV), Junin (JUNV), Machupo (MACV), Lujo (LUJV), Sabia (SABV ...
Junjie Shao, Yuying Liang, Hinh Ly
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Viruses, 2012 The family Arenaviridae, genus Arenavirus, consists of two phylogenetically independent groups: Old World (OW) and New World (NW) complexes. The Lassa and Lujo viruses in the OW complex and the Guanarito, Junin, Machupo, Sabia, and Chapare viruses in the
Masayuki Saijo +4 more
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[Effect of actinomycin D on the reproduction of the Machupo virus].
Voprosy virusologii, 1985 The effect of inhibitors of mRNA synthesis (actinomycin D and alpha-amanitin) and DNA replication (mitomycin C and ethidium bromide) on Machupo virus reproduction was studied. Actinomycin D (1.0-4.0 micrograms/ml) and alpha-amanitin (10.0 micrograms/ml) added immediately after adsorption reduced the infectious virus titre by 2 lg or more. Actinomycin D
I S, Lukashevich +2 more
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[Monoclonal antibodies to the Machupo virus: their isolation and preliminary characteristics].
Voprosy virusologii, 1992 Six monoclonal antibody-producing hybridoma cell lines were generated by fusion of NS-1 myeloma cells with BALB/c immune splenocytes. Monoclonal antibodies (MCA) specific to Machupo virus NP protein were used to study cross-reactivity between pathogenic and nonpathogenic arenaviruses. It was shown that 3140 MCA cross-reacted in IFA with Lassa, Tacaribe,
I V, Malakhova +5 more
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A Multi-Epitope Vaccine Candidate Against Bolivian Hemorrhagic Fever Caused by Machupo Virus
, 2022 Zeeshan Ali +5 more
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[Immunologic indicators in vaccinated mice with Machupo virus infection].
Voprosy virusologii, 1997 The parameters of nonspecific immunity (interferon, interleukin-1, tumor necrosis factor, and natural killers) changed in immune BALB/c mice after challenge with Machupo virus in doses of 1000 and 5000 PFU. After challenge with 1000 PFU the activity of the above parameters increased during the first three days and no cases of animal death occurred ...
I V, Patrusheva +3 more
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