Results 41 to 50 of about 1,789,414 (194)

Coronavirus in human diseases: Mechanisms and advances in clinical treatment

MedComm, Volume 1, Issue 3, Page 270-301, December 2020., 2020
Current mechanisms of anti‐CoV therapeutic strategies. The idea to disturb the normal life cycle of the virus provides significant insights into the clinical treatment strategies. All of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 encode structure proteins (like S protein), nonstructure proteins (eg, PLpro, 3CLpro, RdRp, and helicase), and accessory proteins ...
Panpan Lin, Manni Wang, Yuquan Wei, Taewan Kim, Xiawei Wei   +4 more
wiley   +1 more source

Computational backbone design enables soluble engineering of transferrin receptor apical domain

Proteins: Structure, Function, and Bioinformatics, Volume 88, Issue 12, Page 1569-1577, December 2020., 2020
Abstract Supply of iron into human cells is achieved by iron carrier protein transferrin and its receptor that upon complex formation get internalized by endocytosis. Similarly, the iron needs to be delivered into the brain, and necessitates the transport across the blood‐brain barrier. While there are still unanswered questions about these mechanisms,
Dick J. Sjöström, Sarah A. Berger, Gustav Oberdorfer, Sinisa Bjelic   +3 more
wiley   +1 more source

Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses

Journal of Infection and Public Health, 2023
Background: Multiplex real-time PCR is a quick and cost effective method for detection of various gene simultaneously. HFSV (Hemorrhagic Fever Syndrome Virus) is a newly emerging infectious disease because of globalization and climate change. We tried to
Yoonhyuk Choi, Younghee Kim
doaj   +1 more source

Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes

Cellular Microbiology, Volume 22, Issue 1, January 2020., 2020
Abstract Plasmodium vivax is responsible for most of the malaria infections outside Africa and is currently the predominant malaria parasite in countries under elimination programs. P. vivax preferentially enters young red cells called reticulocytes. Advances in understanding the molecular and cellular mechanisms of entry are hampered by the inability ...
Li‐Jin Chan, Melanie H. Dietrich, Wang Nguitragool, Wai‐Hong Tham   +3 more
wiley   +1 more source

Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses

Nature Communications, 2018
The five known New World hemorrhagic fever arenaviruses use the same entry receptor, but their viral glycoproteins are markedly different. Here, the authors isolate monoclonal antibodies from a Junin virus vaccinated person that cross-neutralize Machupo ...
Lars E. Clark, Selma Mahmutovic, Donald D. Raymond, Taleen Dilanyan, Takaaki Koma, John T. Manning, Sundaresh Shankar, Silvana C. Levis, Ana M. Briggiler, Delia A. Enria, Kai W. Wucherpfennig, Slobodan Paessler, Jonathan Abraham   +12 more
doaj   +1 more source

Structural, chemical reactivity, topological, electronic and spectroscopic (Raman, SERS and UV-Vis) and antiviral investigation of Furo [3,2-c] pyridine-2-carbaldehyde

Chemical Physics Impact, 2023
The current work is concerned with the theoretical discernment of adsorption processes between the Furo [3,2-c] pyridine-2-carbaldehyde and bimetallic clusters (Cu-Ag, Cu-Au and Cu-Ni).
Sravanthi R, S Mahalakshmi, V Vetrivelan, S Sakthivel, S Kumaran, S Muthu   +5 more
doaj   +1 more source

Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production

Frontiers in Microbiology, 2020
Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo, Patrick I. Mpingabo, Shuzo Urata, Shuzo Urata, Jiro Yasuda, Jiro Yasuda, Jiro Yasuda   +6 more
doaj   +1 more source

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease. [PDF]

, 2016
UNLABELLED: Arenaviruses are emerging viruses including several causative agents of severe hemorrhagic fevers in humans. The advent of next-generation sequencing technology has greatly accelerated the discovery of novel arenavirus species.
Bergeron, E., Burri, D.J., da Palma, J.R., Khatib, A.M., Kunz, S., Oppliger, J., Pasquato, A., Spiropoulou, C.F.   +7 more
core   +1 more source

Interaction of silver nanoparticles with Tacaribe virus [PDF]

, 2010
Background Silver nanoparticles possess many unique properties that make them attractive for use in biological applications. Recently they received attention when it was shown that 10 nm silver nanoparticles were bactericidal, which is ...
Janice L Speshock, Richard C Murdock, Laura K Braydich-Stolle, Amanda M Schrand, Saber M Hussain   +4 more
core   +2 more sources

Differential Immune Responses to Hemorrhagic Fever-Causing Arenaviruses

Vaccines, 2019
The family Arenaviridae contains several pathogens of major clinical importance. The Old World (OW) arenavirus Lassa virus is endemic in West Africa and is estimated to cause up to 300,000 infections each year.
Emily Mantlo, Slobodan Paessler, Cheng Huang   +2 more
doaj   +1 more source