Results 51 to 60 of about 1,789,414 (194)
Heliyon, 2021 Arenaviral infections often result lethal hemorrhagic fevers, affecting primarily in African and South American regions. To date, there is no FDA-approved licensed vaccine against arenaviruses and treatments have been limited to supportive therapy. Hence,
Kazi Faizul Azim +6 more
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A single mutation (V64G) within the RING Domain of Z attenuates Junin virus.
PLoS Neglected Tropical Diseases, 2020 Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence ...
Steven J Hallam +7 more
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Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses
mSphere, 2018 Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological
Fatima Amanat +5 more
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Vaccines for emerging pathogens: prospects for licensure
Clinical &Experimental Immunology, Volume 198, Issue 2, Page 170-183, November 2019., 2019 This review covers the global incidence of disease caused by emerging and re‐emerging pathogens and the availability of vaccines for these. It considers the hurdles to be overcome to achieve comprehensive vaccine coverage and reviews the regulatory mechanisms which may be available to seek approval for human use in emergency situations.
E. D. Williamson, G. E. Westlake
wiley +1 more source
The HIV glycan shield as a target for broadly neutralizing antibodies
The FEBS Journal, Volume 282, Issue 24, Page 4679-4691, December 2015., 2015 The HIV envelope glycoprotein, Env, is extensively decorated with host‐derived N‐linked glycans. These glycans not only shield conserved protein regions from antibody recognition but, critically, act as epitopes for some of the most broad and potent neutralizing antibodies.
Katie J. Doores
wiley +1 more source
Animal Models for the Study of Rodent‐Borne Hemorrhagic Fever Viruses: Arenaviruses and Hantaviruses
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Human pathogenic hantaviruses and arenaviruses are maintained in nature by persistent infection of rodent carrier populations. Several members of these virus groups can cause significant disease in humans that is generically termed viral hemorrhagic fever (HF) and is characterized as a febrile illness with an increased propensity to cause acute ...
Joseph W. Golden +4 more
wiley +1 more source
Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage [PDF]
, 2010 Background Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Arenaviridae family.
Maya F Kotturi +12 more
core +2 more sources
Multiplex Degenerate Primer Design for Targeted Whole Genome Amplification of Many Viral Genomes
Advances in Bioinformatics, Volume 2014, Issue 1, 2014., 2014 Background. Targeted enrichment improves coverage of highly mutable viruses at low concentration in complex samples. Degenerate primers that anneal to conserved regions can facilitate amplification of divergent, low concentration variants, even when the strain present is unknown. Results.
Shea N. Gardner +6 more
wiley +1 more source
Hematology Reports, 2020 World Health Organization (WHO) declared coronavirus disease (COVID-19) a pandemic in March 2020. Currently almost every country in the world has reported cases with moderate to high mortality rates. The European Union (EU), the United States of America (
Seidu A. Richard +2 more
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Virions at the gates: receptors and the host-virus arms race. [PDF]
PLoS Biology, 2013 All viruses need to bind to specific receptor molecules on the surface of target cells to initiate infection. Virus-receptor binding is highly specific, and this specificity determines both the species and the cell type that can be infected by a given ...
John M Coffin
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