Potentiation of antimicrobial activity of colistin with antibiotics of different groups against multidrug- and extensively drug-resistant strains of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa [PDF]
Objective. To reveal antibiotics being capable of potentiating the antimicrobial activity of colistin against multidrug- and extensively drug-resistant strains of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. Materials and
Tapalskiy D.V. +3 more
doaj +1 more source
Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf [PDF]
The pharmacokinetic (PK) profile of tulathromycin, administered to calves subcutaneously at the dosage of 2.5 mg/kg, was established in serum, inflamed (exudate), and noninflamed (transudate) fluids in a tissue cage model. The PK profile of tulathromycin
Aliabadi +35 more
core +4 more sources
Macrolide Therapy in Respiratory Viral Infections
Background. Macrolides have received considerable attention for their anti-inflammatory and immunomodulatory actions beyond the antibacterial effect. These two properties may ensure some efficacy in a wide spectrum of respiratory viral infections.
Jin-Young Min, Yong Ju Jang
doaj +1 more source
Familial Occurrence of Mycoplasma-induced Rash and Mucositis: A Case Report of Two Siblings [PDF]
Mycoplasma pneumoniae is a common pathogen responsible for respiratory infections, including community-acquired pneumonia, and up to 25% of patients develop extrapulmonary complications.
Roja Aepala +4 more
doaj +1 more source
Macrolides: a promising pharmacologic therapy for chronic obstructive pulmonary disease
Chronic inflammation plays a central role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, there are no effective anti-inflammatory pharmacologic therapies available for COPD so far.
Shilin Qiu, Xiaoning Zhong
doaj +1 more source
Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin
We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after ...
Maria Sjölund +4 more
doaj +1 more source
Veterinary Medicine Needs New Green Antimicrobial Drugs [PDF]
Given that: (1) the worldwide consumption of antimicrobial drugs (AMDs) used in food-producing animals will increase over the coming decades; (2) the prudent use of AMDs will not suffice to stem the rise in human antimicrobial resistance (AMR) of animal ...
Adams +97 more
core +5 more sources
Community-acquired pneumonia: antibiotic therapy approach after the COVID-19 pandemic. A review
Pneumonia is clearly differentiated from other focal inflammatory lung diseases of non-infectious origin. A patient with community-acquired pneumonia (CAP) should receive antibacterial drugs no later than 4 hours after the diagnosis.
Andrey A. Zaytsev, Igor A. Guchev
doaj +1 more source
From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials
Macrolides, as a class of natural or semisynthetic products, express their antibacterial activity primarily by reversible binding to the bacterial 50S ribosomal subunits and by blocking nascent proteins’ progression through their exit tunnel in bacterial
Dubravko Jelić, Roberto Antolović
doaj +1 more source
Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types [PDF]
The aim of this study was to examine the gene transfer potential of mef(A)-containing Tn120.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types.
Hadjirin, N. F. +3 more
core +1 more source

