Results 11 to 20 of about 4,994,603 (399)

A common framework of monocyte-derived macrophage activation

Science immunology, 2022
Macrophages populate every organ during homeostasis and disease, displaying features of tissue imprinting and heterogeneous activation. The disconnected picture of macrophage biology that has emerged from these observations is a barrier for integration ...
David E Sanin, Yan Ge, E. Marinković, A. Kabat, Angela Castoldi, G. Caputa, Katarzyna M. Grzes, Jonathan D. Curtis, E. Thompson, S. Willenborg, S. Dichtl, S. Reinhardt, A. Dahl, Erika L. Pearce, S. Eming, A. Gerbaulet, Axel Roers, P. J. Murray, E. Pearce   +18 more
semanticscholar   +1 more source

Solanum nigrum induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK

Food and Agricultural Immunology, 2022
In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and macrophage autophagy in RAW264.7 cells. SNAP increased the production of immunostimulatory factors and phagocytosis in RAW264.7 cells.
Ju Hyung Yu, Min Yeong Choi, So Jung Park, Na Gyeong Geum, Jae Won Lee, Gwang Hun Park, Hyun Ji Eo, Jin Boo Jeong   +7 more
doaj   +1 more source

Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation

Science Advances, 2021
CRISPR screening identifies RNA m6A modification as negative regulator of TLR signaling pathway for proper innate immune response. m6A RNA modification is implicated in multiple cellular responses.
Jiyu Tong, Xuefei Wang, Yongbo Liu, Xingxing Ren, Anmin Wang, Zonggui Chen, Jiameng Yao, Kaiqiong Mao, Tingting Liu, Fei-Long Meng, Wen Pan, Qiang Zou, Jun Liu, Yu Zhou, Q. Xia, R. Flavell, Shu Zhu, Hua-Bing Li   +17 more
semanticscholar   +1 more source

Macrophage Activation in Systemic Sclerosis [PDF]

JACC: Basic to Translational Science
Maria Caterina Turco, PhD, Nicoletta Del Papa, MD, Marco Vicenzi, MD, Liberato Marzullo, PhD, Alessandra Rosati, PhD, Margot De Marco, PhD   +5 more
doaj   +2 more sources

ARRB1 suppresses the activation of hepatic macrophages via modulating endoplasmic reticulum stress in lipopolysaccharide-induced acute liver injury

Cell Death Discovery, 2021
Acute liver injury (ALI) caused by multiple inflammatory responses is a monocyte-/macrophage-mediated liver injury that is associated with high morbidity and mortality. Liver macrophage activation is a vital event that triggers ALI.
Yiming Lei, Sizhe Wan, Huiling Liu, Haoxiong Zhou, Lingjun Chen, Yidong Yang, Bin Wu   +6 more
doaj   +1 more source

In Vitro Screening Method for Characterization of Macrophage Activation Responses

Methods and Protocols, 2022
Macrophage activation refers to the enhanced functionality of macrophages in response to endogenous or exogenous stimuli. Due to the existence of limitless stimuli and a multitude of receptors on macrophage surfaces, the nature of activation (or acquired
Brandon W. Lewis, Sonika Patial, Yogesh Saini   +2 more
doaj   +1 more source

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

Autoimmunity Reviews, 2020
Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-inflammation designated under the umbrella term of macrophage activation syndrome (MAS) or cytokine storm, also known as secondary haemophagocytic lymphohistocytosis ...
D. McGonagle, K. Sharif, A. O’Regan, C. Bridgewood   +3 more
semanticscholar   +1 more source

Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis in cerebellar and brain stem areas

Frontiers in Neurology, 2023
IntroductionThis study aimed to investigate microglial and macrophage activation in 17 patients who died in the context of a COVID-19 infection in 2020 and 2021.MethodsThrough immunohistochemical analysis, the lysosomal marker CD68 was used to detect ...
Julian A. Stein, Manuel Kaes, Sigrun Smola, Sigrun Smola, Walter J. Schulz-Schaeffer   +4 more
doaj   +1 more source

Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages

Frontiers in Molecular Biosciences, 2021
Macrophage activation is an important process in controlling infection, but persistent macrophage activation leads to chronic inflammation and diseases, such as tumor progression, insulin resistance and atherosclerosis.
Jing Liu, Zhaoyun Zong, Wenhao Zhang, Yuling Chen, Xueying Wang, Jie Shen, Changmei Yang, Xiaohui Liu, Haiteng Deng   +8 more
doaj   +1 more source

A Review on Macrophage Activation Syndrome

Journal of Pure and Applied Microbiology, 2019
MAS, which is currently grouped under secondary or acquired haemophagocytic lymphohistiocytosis (sHLH), is a rare and fatal disorder that results from excess activation of T-cells and macrophages.
Preeti Sharma, Shailza Shreshtha, Pradeep Kumar, Rachna Sharma, T.K. Mahapatra   +4 more
doaj   +1 more source