Results 41 to 50 of about 4,994,603 (399)

The Immunology of Macrophage Activation Syndrome

Frontiers in Immunology, 2019
Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening complication of systemic inflammatory disorders, most commonly systemic ...
C. Crayne, Sabrin H Albeituni, K. Nichols, R. Cron   +3 more
semanticscholar   +1 more source

Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus

Theranostics, 2020
Rationale: Macrophages play critical roles in the pathogenesis of type 1 diabetes mellitus (T1DM). Circular RNAs (circRNAs) are a novel class of endogenous RNAs with covalently closed loop structures, implicated in various disease processes.
Caiyan Zhang, Xiao Han, Lan Yang, Jinrong Fu, Chengjun Sun, Saihua Huang, Wenfeng Xiao, Yajing Gao, Qiuyan Liang, Xiang Wang, F. Luo, Wei-Yu Lu, Yufeng Zhou   +12 more
semanticscholar   +1 more source

Metabolism fine-tunes macrophage activation

eLife, 2016
A signaling pathway that rewires metabolism in macrophages to trigger changes in gene expression has been identified.
AnnMarie Torres, Liza Makowski, Kathryn E Wellen   +2 more
doaj   +1 more source

Macrophage activation syndrome in COVID-19

Акушерство, гинекология и репродукция, 2021
The novel coronavirus epidemic is characterized by high rates of morbidity and relatively high mortality. Laboratory test results in patients include leukopenia, an increase in liver function tests and ferritin levels reaching hundreds, and sometimes ...
K. N. Grigorieva, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, D. V. Blinov, V. I. Tsibizova, D. A. Ponomarev, A. S. Shkoda, E. A. Orudzhova, E. Grandone, G. Rizzo, A. D. Makatsariya   +11 more
doaj   +1 more source

Activation of Murine Macrophages [PDF]

Current Protocols in Immunology, 2008
AbstractOur understanding of cell mediated immunity (CMI) has revealed the importance of activated macrophages as key immune effector cells. Over the past decade, we have come to realize that macrophages exhibit remarkable plasticity, and different populations of macrophages with distinct physiologies can develop in response to different stimuli.
David M, Mosser, Xia, Zhang
openaire   +2 more sources

Macrophage Activation Syndrome

International Journal of Surgical Pathology, 2013
Zespół aktywacji makrofaga (<i>macrophage activation syndrome</i> – MAS) jest ciężkim powikłaniem układowych chorób tkanki łącznej, głównie układowej postaci młodzieńczego idiopatycznego zapalenia stawów, tocznia rumieniowatego układowego oraz choroby Stilla u dorosłych.
Nidhi, Aggarwal, Rohit, Aggarwal
openaire   +3 more sources

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]

, 2015
Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay, Habtezion, Aida, Hsieh, Michael H, Murali, Ramachandran, Pandol, Stephen J, Sharma, Vishal, Xue, Jing   +6 more
core   +2 more sources

Reactive oxygen species (ROS) in macrophage activation and function in diabetes.

Immunobiology, 2019
In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This contributes to the vascular complications of diabetes. Recent studies have shown that ROS formation is exacerbated in diabetic monocytes and macrophages due to a ...
Erika Rendra, V. Riabov, Dieuwertje M. Mossel, T. Sevastyanova, M. Harmsen, J. Kzhyshkowska   +5 more
semanticscholar   +1 more source

Deep RNA Sequencing Uncovers a Repertoire of Human Macrophage Long Intergenic Noncoding RNAs Modulated by Macrophage Activation and Associated With Cardiometabolic Diseases

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSustained and dysfunctional macrophage activation promotes inflammatory cardiometabolic disorders, but the role of long intergenic noncoding RNA (lincRNA) in human macrophage activation and cardiometabolic disorders is poorly defined.
Hanrui Zhang, Chenyi Xue, Ying Wang, Jianting Shi, Xuan Zhang, Wenjun Li, Sara Nunez, Andrea S. Foulkes, Jennie Lin, Christine C. Hinkle, Wenli Yang, Edward E. Morrisey, Daniel J. Rader, Mingyao Li, Muredach P. Reilly   +14 more
doaj   +1 more source

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19

Scientific Reports, 2021
Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS).
Abu Saleh Md Moin, Thozhukat Sathyapalan, Ilhame Diboun, Stephen L. Atkin, Alexandra E. Butler   +4 more
doaj   +1 more source