Results 41 to 50 of about 641,749 (286)

Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury

Cell Death Discovery, 2023
Aged livers have shown aggravated liver ischemia and reperfusion (IR) injury. Timely efferocytosis of apoptotic cells is a key mechanism for avoiding excessive inflammation and tissue injury.
Haoran Hu, Xuyu Cheng, Fei Li, Zhu Guan, Jian Xu, Dongming Wu, Yiyun Gao, Xinyu Zhan, Ping Wang, Haoming Zhou, Zhuqing Rao, Feng Cheng   +11 more
doaj   +1 more source

α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis

Frontiers in Cell and Developmental Biology, 2021
BackgroundNicotine exerts direct effects on multiple cell types in the cardiovascular system by associating with its high-affinity nicotinic acetylcholine receptors (nAchRs).
Fengqi Duan, Cheng Zeng, Sijun Liu, Jianfeng Gong, Jia Hu, Hongyu Li, Hongmei Tan, Hongmei Tan, Hongmei Tan   +8 more
doaj   +1 more source

Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages. [PDF]

, 1984
We have determined the effect of various endocytic ligands on the secretion of ApoE by macrophages. ApoE was a major secreted protein of resident macrophages, but BCG-activated macrophages secreted little ApoE and periodate-elicited macrophages secreted ...
Takemura, R, Werb, Z
core   +2 more sources

Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification

Frontiers in Immunology
IntroductionMacrophage activation is closely associated with Acute pancreatitis (AP). We screened and found that Growth factor receptor bound protein 2 (Grb2) is highly expressed in macrophages during AP.
Qinhao Shen, Shuai Wang, Keyan Wu, Liuhui Wang, Weijuan Gong, Guotao Lu, Weiwei Chen, Chenchen Yuan, Bo Tu, Wei Li, Yaodong Wang, Weixuan Yang   +11 more
doaj   +1 more source

Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.

PLoS Genetics, 2015
Macrophages display flexible activation states that range between pro-inflammatory (classical activation) and anti-inflammatory (alternative activation). These macrophage polarization states contribute to a variety of organismal phenotypes such as tissue
Musa A Hassan, Kirk D Jensen, Vincent Butty, Kenneth Hu, Erwan Boedec, Pjotr Prins, Jeroen P J Saeij   +6 more
doaj   +1 more source

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

Frontiers in Immunology, 2020
Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses. Macrophages [Raw 264.7
Kun Yang, Kun Yang, Jingjing Xu, Min Fan, Min Fan, Fei Tu, Fei Tu, Xiaohui Wang, Tuanzhu Ha, Tuanzhu Ha, David L. Williams, David L. Williams, Chuanfu Li, Chuanfu Li   +13 more
doaj   +1 more source

XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression

JHEP Reports, 2022
Background & Aims: XBP1 modulates the macrophage proinflammatory response, but its function in macrophage stimulator of interferon genes (STING) activation and liver fibrosis is unknown.
Qi Wang, Qingfa Bu, Mu Liu, Rui Zhang, Jian Gu, Lei Li, Jinren Zhou, Yuan Liang, Wantong Su, Zheng Liu, Mingming Wang, Zhexiong Lian, Ling Lu, Haoming Zhou   +13 more
doaj   +1 more source

CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3 [PDF]

, 2018
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer.
Amézaga, Núria, Aran, Gemma, Armengol, Carolina, López Codina, Daniel, Prats Soler, Clara, Sanjurjo, Lucía, Sarrias, Maria Rosa, Téllez, Érica   +7 more
core   +2 more sources

Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene

Ecotoxicology and Environmental Safety
We have previously shown that excessive activation of macrophage proinflammatory activity plays a key role in TCE-induced immune liver injury, but the mechanism of polarization is unclear. Recent studies have shown that TLR9 activation plays an important
Lei Gao, Xu-Lei Zuo, Luo-Lun Dong, Si-Fan Zhou, Zhou-Jian Wang, Yuan-Sheng Duan, Mu-Yue Chen, Qi-Xing Zhu, Jia-Xiang Zhang   +8 more
doaj   +1 more source

Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans

Emerging Infectious Diseases, 2019
Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and ...
Anita K. McElroy, Punya Shrivastava-Ranjan, Jessica R. Harmon, Roosecelis B. Martines, Luciana Silva-Flannery, Timothy D. Flietstra, Colleen S. Kraft, Aneesh K. Mehta, G. Marshall Lyon, Jay B. Varkey, Bruce S. Ribner, Stuart T. Nichol, Sherif R. Zaki, Christina F. Spiropoulou   +13 more
doaj   +1 more source