Results 41 to 50 of about 3,186 (156)

Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis

Pharmacological Research, 2017
Colorectal cancer (CRC) is a major health problem in Western countries. The endocannabinoid 2-arachidonoyl-glycerol (2-AG) exerts antiproliferative actions in a number of tumoral cell lines, including CRC cells. Monoacylglycerol lipase (MAGL), a serine hydrolase that inactivates 2-AG, is highly expressed in aggressive human cancer cells.
PAGANO, ESTER, BORRELLI, FRANCESCA, Orlando, Pierangelo, ROMANO, BARBARA, Monti, Martina, Morbidelli, Lucia, Aviello, Gabriella, Imperatore, Roberta, CAPASSO, RAFFAELE, Piscitelli, Fabiana, Buono, Lorena, Di Marzo, Vincenzo, IZZO, ANGELO ANTONIO   +12 more
openaire   +5 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

The endocannabinoid systemʼs involvement in motor development relies on cannabinoid receptors, TRP channels, and Sonic Hedgehog signaling

Physiological Reports, 2023
The endocannabinoid system (eCS) plays critical roles in locomotor function and motor development; however, the roles of non‐canonical cannabinoid receptor systems such as transient receptor potential (TRP) channels and the Sonic Hedgehog (SHH) signaling
Lakhan S. Khara, Declan W. Ali
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates

EJNMMI Research, 2022
Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system.
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin   +19 more
doaj   +1 more source

Of Mice and MAGL (Monoacylglycerol Lipase)

The FASEB Journal, 2011
About 18.8 million American adults suffer depressive disorders that may occur with anxiety and substance abuse. Tetrahydrocannabinol (THC), a compound in marijuana, is a cannabinoid chemical that binds to and activates cannabinoid receptors (CB1) in the pre‐synaptic cell membrane as part of neuron‐to‐neuron transmission in the ...
S. Bach, T. Bombinski, M. Daniels, D. Gross, T. Hogg, T. Martin, D. McMurray, E. Naber, N. Perez, A. Schulman, S. Tucker, S. Andera‐Cato, A. Arnold, A. Blumberg, M. Bord, A. Feiertag, M. Greaves, A. Her, E. Kennedy, C. Orozco, C. Rice, A. Rodgers, A. Sauer, J. Schubert, C. Tubbs, T. Wray, G. Vogt, L. Shrestha, C. Hillard   +28 more
openaire   +1 more source

Influence of prey concentration, light intensity, and temperature on the growth and ingestion of the mixotrophic dinoflagellate Pyrophacus horologium, a predator of the harmful species Heterocapsa niei

Journal of Phycology, EarlyView.
Abstract Pyrophacus horologium belongs to the family Pyrocystaceae and was recently identified as a mixotrophic dinoflagellate capable of feeding on other dinoflagellates. In this study, the growth and feeding responses of P. horologium were investigated under various environmental conditions by providing Heterocapsa niei, its preferred prey.
Min‐jun Seong, Kun‐woo Yun, Hwa‐seong Son, Seung‐min Lee, Mu‐chan Kim   +4 more
wiley   +1 more source

3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors

Journal of Pharmacy and Bioallied Sciences, 2014
Purpose: The purpose of this study is to build up the 3D pharmacophore of Monoacylglycerol lipase (MAGL) inhibitor and to provide the basis to design the novel and potent MAGL inhibitors.
Obaid Afzal, Suresh Kumar, Rajiv Kumar, Manu Jaggi, Sandhya Bawa   +4 more
doaj   +1 more source