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MAIT Cells in Health and Disease
2019Mucosal-associated invariant T (MAIT) cells are a newly described subset of T cells that are found in the blood and are enriched in many tissues, particularly in the liver. MAIT cells express a semi-invariant T cell receptor restricted by the MHC class I-related (MR1) molecule. MAIT cells are activated in a MR1-dependent manner in response to microbial-
Isabelle, Magalhaes +2 more
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MAIT cells and pathogen defense
Cellular and Molecular Life Sciences, 2014Mucosa-associated invariant T (MAIT) cells are a unique population of innate T cells that are abundant in humans. These cells possess an evolutionarily conserved invariant T cell receptor α chain restricted by the nonpolymorphic class Ib major histocompatibility (MHC) molecule, MHC class I-related protein (MR1). The recent discovery that MAIT cells are
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Nature Reviews Immunology, 2019
Commensal bacteria at mucosal surfaces can remotely control the thymic maturation of mucosal-associated invariant T cells through the production of microbial factors that enter the circulation and are taken up by thymic cells.
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Commensal bacteria at mucosal surfaces can remotely control the thymic maturation of mucosal-associated invariant T cells through the production of microbial factors that enter the circulation and are taken up by thymic cells.
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MAITs, MR1 and vitamin B metabolites
Current Opinion in Immunology, 2014αβT-cell mediated immunity is traditionally characterised by recognition of peptides or lipids presented by the major histocompatibility complex (MHC) or the CD1 family respectively. Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of ...
Richard W, Birkinshaw +4 more
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Deficiency in Peripheral MAIT Cells But Not in Intrahepatic MAIT Cells in Humans with CHBV Infection
SSRN Electronic Journal, 2019Background: Chronic hepatitis B virus (CHBV) infection is a major cause of liver diseases. Mucosal-associated invariant T (MAIT) cells are important for antiviral immunity in the liver, but the distinction between intrasinusoidal MAIT cells and peripheral MAIT cells in patients with CHBV infection remains unclear.
Wenyong Huang +6 more
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The biology and functional importance of MAIT cells
Nature Immunology, 2019In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative ...
Dale I. Godfrey +3 more
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MAIT cells as attractive vaccine targets
FEBS Letters, 2019Mucosal‐associated invariant T (MAIT) cells are a subset of T cells that perform innate‐like immunity functions upon recognition of small molecule vitamin B metabolites presented by the MHC, class I‐related protein‐1 (MR1). MAIT cells are profuse in humans, but especially abundant in blood, liver, lungs, and mucosal layers.
A. Michael Downey +2 more
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MAIT Cell Activation by Fungal Pathogens
2019MAIT cells can recognize and respond to several pathogens in a distinct manner. However, many studies are focused on activation by bacteria and by viruses, while reports about molds and MAIT cells are rare. Here, we describe a method to investigate MAIT cell interaction with filamentous fungi from Aspergillus and Mucorales species.
Susanne, Jahreis +2 more
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Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin
Cell, 2023Benjamin Ruf, Lichun Ma, Mahler Revsine
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