Proceedings of the National Academy of Sciences, 1999 Malaria remains one of the most important vector-borne human diseases. Control of malaria caused by Plasmodium falciparum is a major goal, particularly for populations in sub-Saharan Africa. An effective vaccine against malaria that would protect nonimmune individuals from the disease has long been a dream. But will it be a reality?
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Vaccines Against Malaria [PDF]
Clinical Infectious Diseases, 2014 Despite global efforts to control malaria, the illness remains a significant public health threat. Currently, there is no licensed vaccine against malaria, but an efficacious vaccine would represent an important public health tool for successful malaria elimination.
Amed, Ouattara, Matthew B, Laurens
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Experience and Challenges from Clinical Trials with Malaria Vaccines in Africa. [PDF]
, 2013 Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades ...
A Nyika +67 more
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Uptake of three doses of HPV vaccine by primary school girls in Eldoret, Kenya : a prospective cohort study in a malaria endemic setting [PDF]
, 2018 Background: All women are potentially at risk of developing cervical cancer at some point in their life, yet it is avoidable cause of death among women in Sub- Saharan Africa with a world incidence of 530,000 every year.
Kirop, Elijah +8 more
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Malaria vaccine development [PDF]
Clinical Microbiology Reviews, 1994 The malaria parasite life cycle presents several targets for attack, but these different parts of the life cycle are susceptible to different types of host immune response. For example, the sporozoite is most sensitive to immune antibody, while liver stage parasites can be eliminated by cytotoxic T lymphocytes. Attachment of merozoites to erythrocytes,
T R, Jones, S L, Hoffman
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The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]
, 2011 By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG +6 more
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Randomized, Controlled Trial of the Long Term Safety, Immunogenicity and Efficacy of RTS,S/AS02(D) Malaria Vaccine in Infants Living in a Malaria-Endemic Region. [PDF]
, 2013 The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization.
A Olotu +43 more
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The rise of companies from emerging markets in global health governance: opportunities and challenges [PDF]
, 2014 The article analyses the involvement of pharmaceutical companies from emerging markets in global health governance. It finds that they play a central role as low-cost suppliers of medicines and vaccines and, increasingly, new technologies.
ANNE ROEMER-MAHLER +23 more
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Grid Added Value to Address Malaria [PDF]
, 2006 Through this paper, we call for a distributed, internet-based collaboration to address one of the worst plagues of our present world, malaria. The spirit is a non-proprietary peer-production of information-embedding goods.
Breton, V. +3 more
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Antibody and B cell responses to Plasmodium sporozoites [PDF]
, 2014 Antibodies are capable of blocking infection of the liver by Plasmodium sporozoites. Accordingly the induction of anti-sporozoite antibodies is a major aim of various vaccine approaches to malaria.
Cockburn, Ian A. +2 more
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