Evolution of an expanded mannose receptor gene family. [PDF]
PLoS ONE, 2014 Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B.
Karen Staines +3 more
doaj +6 more sources
The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation [PDF]
Frontiers in Immunology, 2021 The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and internalize a variety of endogenous and pathogen-associated ligands.
Hendrik J. P. van der Zande +4 more
doaj +3 more sources
Mannose Ligands for Mannose Receptor Targeting. [PDF]
Int J Mol SciThe mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides.
Paurević M +2 more
europepmc +4 more sources
Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages [PDF]
eLife, 2020 HIV-1 Vpr is necessary for maximal HIV infection and spread in macrophages. Evolutionary conservation of Vpr suggests an important yet poorly understood role for macrophages in HIV pathogenesis.
Jay Lubow +11 more
doaj +3 more sources
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. [PDF]
J Biol Chem, 2021 Feinberg H +6 more
europepmc +4 more sources
Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Obesity-associated metaflammation is an emerging disease, in which proinflammatory macrophages play a decisive role. Here, we identified the soluble mannose receptor (sMR) as a regulator of metaflammation and demonstrated increased levels of
Embgenbroich M +21 more
europepmc +2 more sources
Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis [PDF]
BMC Pediatrics, 2021 Introduction The differentiation between systemic inflammatory response syndrome and sepsis is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy.
Noha A. Hassuna +7 more
doaj +2 more sources
Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis [PDF]
Scientific Reports, 2018 Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB).
Yuzo Suzuki +13 more
openalex +2 more sources
Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides. [PDF]
PLoS ONE, 2008 While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antigens ...
Jennifer M Dan +3 more
doaj +12 more sources
Macrophage Activation Markers, Soluble CD163 and Mannose Receptor, in Liver Fibrosis. [PDF]
Front Med (Lausanne), 2020 Macrophages are essential components of the human host immune system, which upon activation facilitates a broad pallet of immunomodulatory events including release of pro- or anti-inflammatory cytokines and chemokines, restoration of immune homeostasis ...
Gantzel RH +6 more
europepmc +2 more sources