Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition [PDF]
VirulenceThe detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear.
Hong Zhang +6 more
doaj +2 more sources
Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2021 We describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the
Dewton de Moraes Vasconcelos +2 more
doaj +2 more sources
The Mannose Receptor in Regulation of Helminth-Mediated Host Immunity
Frontiers in Immunology, 2017 Infection with parasitic helminths affects humanity and animal welfare. Parasitic helminths have the capacity to modulate host immune responses to promote their survival in infected hosts, often for a long time leading to chronic infections.
Irma van Die, Richard D. Cummings
doaj +2 more sources
Journal of Leukocyte Biology, 2012 Abstract Review on mannose receptor as an endocytic receptor in antigen delivery that is co-expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a highly effective endocytic receptor with a broad binding specificity encompassing ligands of microbial and endogenous origin and a poorly characterized
L. Martínez-Pomares
openaire +3 more sources
The mannose receptor ligands and the macrophage glycome. [PDF]
Curr Opin Struct Biol, 2022 Cummings RD.
europepmc +2 more sources
Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing [PDF]
mAbsDuring the development process of therapeutic monoclonal antibodies (mAbs), it is crucial to control (critical) quality attributes such as N-glycosylation influencing pharmacokinetics (PK) and Fc effector functions.
Julia Baumeister +7 more
doaj +2 more sources
Characterization of functional mannose receptor in a continuous hybridoma cell line
BMC Immunology, 2012 Background The mannose receptor is the best described member of the type I transmembrane C-type lectins; however much remains unanswered about the biology of the receptor.
Vigerust David J +2 more
doaj +2 more sources
Science Translational Medicine, 2020 Innate defense regulator RP-182 targets CD206high M2-like macrophages in malignant and noncancerous diseases. Spinning ancient peptides into gold Tumors co-opt macrophages to promote tumor growth and evasion from immune surveillance.
Jesse M. Jaynes +42 more
openalex +3 more sources
Mannose Receptor 2 Attenuates Renal Fibrosis [PDF]
Journal of the American Society of Nephrology, 2012 Mannose receptor 2 (Mrc2) expresses an extracellular fibronectin type II domain that binds to and internalizes collagen, suggesting that it may play a role in modulating renal fibrosis. Here, we found that Mrc2 levels were very low in normal kidneys but subsets of interstitial myofibroblasts and macrophages upregulated Mrc2 after unilateral ureteral ...
Jesús M, López-Guisa +10 more
openaire +3 more sources
Targeting the Mannose Receptor with Functionalized Fucoidan/Chitosan Nanoparticles Triggers the Classical Activation of Macrophages. [PDF]
Int J Mol Sci, 2023 Serrasqueiro F +3 more
europepmc +3 more sources