Results 11 to 20 of about 84,098 (261)

Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance

Nature Communications, 2021
Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.
Huan Cao, Aristotelis Antonopoulos, Sadie Henderson, Heather Wassall, John Brewin, Alanna Masson, Jenna Shepherd, Gabriela Konieczny, Bhinal Patel, Maria-Louise Williams, Adam Davie, Megan A. Forrester, Lindsay Hall, Beverley Minter, Dimitris Tampakis, Michael Moss, Charlotte Lennon, Wendy Pickford, Lars Erwig, Beverley Robertson, Anne Dell, Gordon D. Brown, Heather M. Wilson, David C. Rees, Stuart M. Haslam, J. Alexandra Rowe, Robert N. Barker, Mark A. Vickers   +27 more
doaj   +1 more source

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives

Cells, 2021
Betacoronaviruses, responsible for the “Severe Acute Respiratory Syndrome” (SARS) and the “Middle East Respiratory Syndrome” (MERS), use the spikes protruding from the virion envelope to attach and subsequently infect the host cells.
Annick Barre, Els J. M. Van Damme, Mathias Simplicien, Sophie Le Poder, Bernard Klonjkowski, Hervé Benoist, David Peyrade, Pierre Rougé   +7 more
doaj   +1 more source

Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier. [PDF]

PLoS ONE, 2012
HIV-1 circulates both as free virus and within immune cells, with the level of free virus being predictive of clinical course. Both forms of HIV-1 cross the blood-brain barrier (BBB) and much progress has been made in understanding the mechanisms by ...
Shinya Dohgu, Jan S Ryerse, Sandra M Robinson, William A Banks   +3 more
doaj   +1 more source

The mannose receptor [PDF]

Journal of Leukocyte Biology, 2012
Abstract Review on mannose receptor as an endocytic receptor in antigen delivery that is co-expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a highly effective endocytic receptor with a broad binding specificity encompassing ligands of microbial and endogenous origin and a poorly characterized
openaire   +2 more sources

Characterization of functional mannose receptor in a continuous hybridoma cell line

BMC Immunology, 2012
Background The mannose receptor is the best described member of the type I transmembrane C-type lectins; however much remains unanswered about the biology of the receptor.
Vigerust David J, Vick Sherell, Shepherd Virginia L   +2 more
doaj   +1 more source

Mannose Receptor as a Potential Biomarker for Gastric Cancer: A Pilot Study

The International Journal of Biological Markers, 2017
Background The mannose receptor is an immune adhesion molecule mainly expressed on the surface of antigen-presenting cells such as nonmature dendritic cells and macrophages.
Deng-Rui Liu, Quan-Lin Guan, Ming-Tai Gao, Lei Jiang, Hong-Xia Kang   +4 more
doaj   +1 more source

Mannosylated Polyrotaxanes for Increasing Cellular Uptake Efficiency in Macrophages through Receptor-Mediated Endocytosis

Molecules, 2019
Macrophages play an important role in the regulation of inflammation and immune response as well as the pathogenesis of chronic inflammatory diseases and cancer.
Kai Shibaguchi, Atsushi Tamura, Masahiko Terauchi, Mitsuaki Matsumura, Hiroyuki Miura, Nobuhiko Yui   +5 more
doaj   +1 more source

The Mannose Receptor Is Involved in the Phagocytosis of Mycobacteria-Induced Apoptotic Cells

Journal of Immunology Research, 2016
Upon Mycobacterium tuberculosis infection, macrophages may undergo apoptosis, which has been considered an innate immune response. The pathways underlying the removal of dead cells in homeostatic apoptosis have been extensively studied, but little is ...
Teresa Garcia-Aguilar, Patricia Espinosa-Cueto, Alejandro Magallanes-Puebla, Raúl Mancilla   +3 more
doaj   +1 more source

Mannose Receptor 2 Attenuates Renal Fibrosis [PDF]

Journal of the American Society of Nephrology, 2012
Mannose receptor 2 (Mrc2) expresses an extracellular fibronectin type II domain that binds to and internalizes collagen, suggesting that it may play a role in modulating renal fibrosis. Here, we found that Mrc2 levels were very low in normal kidneys but subsets of interstitial myofibroblasts and macrophages upregulated Mrc2 after unilateral ureteral ...
Jesús M, López-Guisa, Xiaohe, Cai, Sarah J, Collins, Ikuyo, Yamaguchi, Daryl M, Okamura, Thomas H, Bugge, Clare M, Isacke, Claire L, Emson, Scott M, Turner, Stuart J, Shankland, Allison A, Eddy   +10 more
openaire   +2 more sources

The mannose receptor mediates dengue virus infection of macrophages. [PDF]

PLoS Pathogens, 2008
Macrophages (MØ) and mononuclear phagocytes are major targets of infection by dengue virus (DV), a mosquito-borne flavivirus that can cause haemorrhagic fever in humans. To our knowledge, we show for the first time that the MØ mannose receptor (MR) binds
Joanna L Miller, Barend J M de Wet, Luisa Martinez-Pomares, Catherine M Radcliffe, Raymond A Dwek, Pauline M Rudd, Siamon Gordon   +6 more
doaj   +1 more source