Results 21 to 30 of about 2,403,795 (378)
Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. [PDF]
PLoS ONE, 2011 Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and CD206
Denarda Dangaj +10 more
doaj +1 more source
Molecules, 2022 Punicalagin is the most bioactive pomegranate polyphenol with high antioxidant and free-radical scavenging activity and can potentially cure different ailments related to the cardiovascular system.
Ritu Karwasra +6 more
doaj +1 more source
Mannosylation of virus-like particles enhances internalization by antigen presenting cells. [PDF]
PLoS ONE, 2014 Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses.
Farah Al-Barwani +4 more
doaj +1 more source
Nature Communications, 2021 Red blood cells (RBCs) are phagocytosed in the spleen in sickle cell disease and malaria. Here, Cao et al. show that high mannose N-glycans, exposed on diseased or oxidized RBC surfaces, bind mannose receptor CD206 on host cells, mediating phagocytosis.
Huan Cao +27 more
doaj +1 more source
Structural Model for the Mannose Receptor Family Uncovered by Electron Microscopy of Endo180 and the Mannose Receptor [PDF]
Journal of Biological Chemistry, 2006 The mannose receptor family comprises four members in mammals, Endo180 (CD280), DEC-205 (CD205), phospholipase A(2) receptor (PLA(2)R) and the mannose receptor (MR, CD206), whose extracellular portion contains a similar domain arrangement: an N-terminal cysteine-rich domain (CysR) followed by a single fibronectin type II domain (FNII) and 8-10 C-type ...
Boskovic, Jasminka +9 more
openaire +4 more sources
Signalling C-Type Lectins in Antimicrobial Immunity [PDF]
, 2013 Funding: This work was funded by the Wellcome Trust, Medical Research Council and the University of Aberdeen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Brown, Gordon D., Drummond, Rebecca A.
core +12 more sources
Cells, 2021 Betacoronaviruses, responsible for the “Severe Acute Respiratory Syndrome” (SARS) and the “Middle East Respiratory Syndrome” (MERS), use the spikes protruding from the virion envelope to attach and subsequently infect the host cells.
Annick Barre +7 more
doaj +1 more source
Science Translational Medicine, 2020 Innate defense regulator RP-182 targets CD206high M2-like macrophages in malignant and noncancerous diseases. Spinning ancient peptides into gold Tumors co-opt macrophages to promote tumor growth and evasion from immune surveillance.
J. Jaynes +42 more
semanticscholar +1 more source
Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors [PDF]
Proceedings of the National Academy of Sciences, 2006 Enzyme replacement therapy (ERT) is available for several lysosomal storage diseases. Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR).
Shunji Tomatsu +7 more
openaire +3 more sources
Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier. [PDF]
PLoS ONE, 2012 HIV-1 circulates both as free virus and within immune cells, with the level of free virus being predictive of clinical course. Both forms of HIV-1 cross the blood-brain barrier (BBB) and much progress has been made in understanding the mechanisms by ...
Shinya Dohgu +3 more
doaj +1 more source