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Effect of the p38 MAPK Inhibitor on the Expression of Metalloproteinases and Their Inhibitors during the Formation of Abdominal Adhesions [PDF]

International Journal of Biomedicine, 2021
Background: The aim of this study was to assess the effect of blockade of the p38 mitogen-activated protein kinase (MAPK) on the expression of genes encoding metalloproteinases (MMPs) during the formation of adhesions in the abdominal cavity.
Irina A. Shurygina, Lyubov V. Rodionova, Natalia I. Ayushinova, Elena E. Chepurnykh, Irina S. Trukhan, Michael G. Shurygin   +5 more
doaj   +1 more source

Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways

Bone & Joint Research, 2023
Aims: Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti ...
Rui Lu, Ying-Guang Wang, Yunkun Qu, Shan-Xi Wang, Cheng Peng, Hongbo You, Wentao Zhu, Anmin Chen   +7 more
doaj   +1 more source

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

Signal Transduction and Targeted Therapy, 2023
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality, underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis, chemoresistance, and the mechanistic backgrounds of
Md Entaz Bahar, Hyun Joon Kim, D. Kim
semanticscholar   +1 more source

Insidious Onset of Pulmonary Langerhans Cell Histiocytosis During Oncological Follow-Up

Journal of the Belgian Society of Radiology, 2022
Teaching Point: Pulmonary Langerhans cell histiocytosis (PLCH) has to be included in the differential diagnosis of cystic pulmonary lesions on chest computed tomography (CT).
Nico Hustings, Eveline Slachmuylders, Adriana Dubbeldam   +2 more
doaj   +1 more source

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Ma, Jiao, Meng, Xiao-Wen, Peng, Ke, Song, Nan, Song, Shao-Yong, Wang, Hui, Zhang, Juan   +10 more
core   +1 more source

Structural Diversity and Role of Phytochemicals against P38-α Mitogen-activated Protein Kinase and Epidermal Growth Factor Receptor Kinase Domain: A Privileged Computational Approach

Journal of Pure and Applied Microbiology, 2021
Computational databases and tools in recent times have been proved to provide an essential aid for anticancer studies in the field of oncology. Molecular docking studies facilitate the structural diversity of plant-derived phytomolecules having ...
Amar Shankar, S.M. Gopinath, Shiva Prasad Kollur, P. Sushma, Anisha S. Jain, Sharanagouda S. Patil, Chandrashekar Srinivasa, Shivalingaiah, Chandan Shivamallu   +8 more
doaj   +1 more source

ERK/MAPK signalling pathway and tumorigenesis

Experimental and Therapeutic Medicine, 2020
Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses.
Yan-Jun Guo, Wei-Wei Pan, Sheng-Bing Liu, Z. Shen, Ying Xu, Ling-Ling Hu   +5 more
semanticscholar   +1 more source

The Winner Takes It All: Auxin–The Main Player during Plant Embryogenesis

Cells, 2020
In plants, the first asymmetrical division of a zygote leads to the formation of two cells with different developmental fates. The establishment of various patterns relies on spatial and temporal gene expression, however the precise mechanism responsible
Konrad Winnicki
doaj   +1 more source

MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence

Autophagy Reports, 2022
Aberrant production of reactive oxygen species (ROS) from dysfunctional mitochondria leads to oxidative stress and DNA damage, which induces the cellular senescence stress response pathway.
Lorenzo Franci, Giovanni Inzalaco, Mario Chiariello   +2 more
doaj   +1 more source

Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids

Frontiers in Bioscience-Landmark, 2021
Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents.
Hanlin Ye, Linlin Wang, Li Ma, Maksim Ionov, Gan Qiao, Jianlin Huang, Li Cheng, Yuxi Zhang, Xiaohui Yang, Shousong Cao, Xiukun Lin   +10 more
doaj   +1 more source