Results 1 to 10 of about 381,061 (150)

Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways

open access: yesBone & Joint Research, 2023
Aims: Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti ...
Rui Lu   +7 more
doaj   +1 more source

Insidious Onset of Pulmonary Langerhans Cell Histiocytosis During Oncological Follow-Up

open access: yesJournal of the Belgian Society of Radiology, 2022
Teaching Point: Pulmonary Langerhans cell histiocytosis (PLCH) has to be included in the differential diagnosis of cystic pulmonary lesions on chest computed tomography (CT).
Nico Hustings   +2 more
doaj   +1 more source

Structural Diversity and Role of Phytochemicals against P38-α Mitogen-activated Protein Kinase and Epidermal Growth Factor Receptor Kinase Domain: A Privileged Computational Approach

open access: yesJournal of Pure and Applied Microbiology, 2021
Computational databases and tools in recent times have been proved to provide an essential aid for anticancer studies in the field of oncology. Molecular docking studies facilitate the structural diversity of plant-derived phytomolecules having ...
Amar Shankar   +8 more
doaj   +1 more source

The Winner Takes It All: Auxin–The Main Player during Plant Embryogenesis

open access: yesCells, 2020
In plants, the first asymmetrical division of a zygote leads to the formation of two cells with different developmental fates. The establishment of various patterns relies on spatial and temporal gene expression, however the precise mechanism responsible
Konrad Winnicki
doaj   +1 more source

MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence

open access: yesAutophagy Reports, 2022
Aberrant production of reactive oxygen species (ROS) from dysfunctional mitochondria leads to oxidative stress and DNA damage, which induces the cellular senescence stress response pathway.
Lorenzo Franci   +2 more
doaj   +1 more source

Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids

open access: yesFrontiers in Bioscience-Landmark, 2021
Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents.
Hanlin Ye   +10 more
doaj   +1 more source

Reactive oxygen species mediate TNF-α-induced inflammatory response in bone marrow mesenchymal cells [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2019
Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β ...
Liuzhong Wu, Yaping Pan
doaj   +1 more source

Langerhans Cell Histiocytosis in Adults: Treatment Opportunities of Today

open access: yesКлиническая онкогематология, 2021
Langerhans cell histiocytosis (LCH) is an extremely rare disease associated with tissue infiltration by pathological cells which are phenotypically similar to normal Langerhans cells.
Vitalii Dmitrievich Latyshev   +1 more
doaj   +1 more source

Transcriptome analysis revealed MAPK and hormone pathway involving in exogenous melatonin-regulated salt tolerance in sour jujube

open access: yesFruit Research, 2023
Melatonin (MT) plays an important role in plant growth and development, and response to biotic and abiotic stresses. Salt stress is one of the major abiotic stresses affecting plant growth and distribution.
Wenhui Zhu   +8 more
doaj   +1 more source

Effect and mechanism of H. pylori in regulation of REDD1 expression in gastric mucosa

open access: yesDi-san junyi daxue xuebao, 2022
Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H.
YAN Zongbao   +4 more
doaj   +1 more source

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