Results 11 to 20 of about 514,036 (239)
Frontiers in Neurology, 2013 The nature of "toxic" tau in Alzheimer's disease (AD) has been unclear. During pathogenesis, the importance of tau oligomerization vs. tau phosphorylation is controversial and the investigation of both remains critical toward defining the "toxicity" of tau.
Gloria Lee +3 more
openaire +3 more sources
Chromatin-tethered MAPKs [PDF]
Current Opinion in Cell Biology, 2013 Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that are essential nodes in many cellular regulatory circuits including those that take place on DNA. Most members of the four MAPK subgroups that exist in canonical three kinase cascades-extracellular signal-regulated kinases 1 and 2 (ERK1/2), ERK5, c-Jun N-terminal kinases ...
Aileen M Klein +2 more
openaire +3 more sources
International Journal of Molecular Sciences, 2022 Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider ...
Mateusz Kciuk +4 more
openaire +2 more sources
Pseudophosphatases as Regulators of MAPK Signaling [PDF]
International Journal of Molecular Sciences, 2021 Mitogen-activated protein kinase (MAPK) signaling pathways are highly conserved regulators of eukaryotic cell function. These enzymes regulate many biological processes, including the cell cycle, apoptosis, differentiation, protein biosynthesis, and oncogenesis; therefore, tight control of the activity of MAPK is critical.
Emma Marie Wilber Hepworth +1 more
openaire +3 more sources
Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2 [PDF]
Plant Signaling & Behavior, 2010 Mitogen-activated protein kinase (MAPK) pathways play crucial roles in developmental and adaptive responses. Depending on the stimulus, MAPK activation regulates a wide variety of plant cell responses, such as proliferation, differentiation and cell death, which normally require precise spatial and temporal control.
Vilela, Belmiro +2 more
openaire +4 more sources
Aging, 2015 Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as "low-risk" and "high-risk" syndromes on the basis of their risk of progression to acute leukemia.
Guillermo Garcia-Manero +2 more
openaire +2 more sources
The roles of MAPKs in disease [PDF]
Cell Research, 2008 MAP kinases transduce signals that are involved in a multitude of cellular pathways and functions in response to a variety of ligands and cell stimuli. Aberrant or inappropriate functions of MAPKs have now been identified in diseases ranging from cancer to inflammatory disease to obesity and diabetes.
Chunli Shao +11 more
openaire +3 more sources
Nuclear Signaling of Plant MAPKs [PDF]
Frontiers in Plant Science, 2018 Mitogen-activated protein kinases (MAPKs) are conserved protein kinases in eukaryotes that establish signaling modules where MAPK kinase kinases (MAPKKKs) activate MAPK kinases (MAPKKs) which in turn activate MAPKs. In plants, they are involved in the signaling of multiple environmental stresses and developmental programs.
Jean Bigeard +2 more
openaire +7 more sources
Not your Mother’s MAPKs: Apicomplexan MAPK function in daughter cell budding
PLOS Pathogens, 2022 Reversible phosphorylation by protein kinases is one of the core mechanisms by which biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, are conserved throughout eukaryotes where they regulate cell cycle, development, and stress response.
William J. O’Shaughnessy +3 more
openaire +4 more sources
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases [PDF]
Microbiology and Molecular Biology Reviews, 2011 SUMMARYThe mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by relaying extracellular signals to intracellular responses. In mammals, there are more than a dozen MAPK enzymes that coordinately regulate cell proliferation, differentiation, motility, and survival.
Philippe P. Roux, Marie Cargnello
openaire +4 more sources