Results 11 to 20 of about 736,655 (384)
Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
International Journal of Molecular Sciences, 2022 c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members integrate signals that affect proliferation, differentiation, survival, and migration in a cell context- and cell type-specific way.
Lesley Jia Wei Pua +6 more
semanticscholar +1 more source
MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma
Cancers, 2021 Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the most lethal cancers in humans.
Hyuk Moon, S. Ro
semanticscholar +1 more source
Reactive oxygen species mediate TNF-α-induced inflammatory response in bone marrow mesenchymal cells [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β ...
Liuzhong Wu, Yaping Pan
doaj +1 more source
Langerhans Cell Histiocytosis in Adults: Treatment Opportunities of Today
Клиническая онкогематология, 2021 Langerhans cell histiocytosis (LCH) is an extremely rare disease associated with tissue infiltration by pathological cells which are phenotypically similar to normal Langerhans cells.
Vitalii Dmitrievich Latyshev +1 more
doaj +1 more source
Understanding MAPK Signaling Pathways in Apoptosis
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or ...
Jicheng Yue, José M. López
semanticscholar +1 more source
Fruit Research, 2023 Melatonin (MT) plays an important role in plant growth and development, and response to biotic and abiotic stresses. Salt stress is one of the major abiotic stresses affecting plant growth and distribution.
Wenhui Zhu +8 more
doaj +1 more source
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
International Journal of Molecular Sciences, 2020 Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease.
Shannon Lee, J. Rauch, W. Kolch
semanticscholar +1 more source
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Journal of Hematology & Oncology, 2020 Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40%
Jimin Yuan +3 more
semanticscholar +1 more source
Effect and mechanism of H. pylori in regulation of REDD1 expression in gastric mucosa
Di-san junyi daxue xuebao, 2022 Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H.
YAN Zongbao +4 more
doaj +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources