Results 21 to 30 of about 514,036 (239)
SnapShot: p38 MAPK Substrates [PDF]
Cell, 2013 p38α mitogen-activated protein kinase (MAPK14) phosphorylates many downstream substrates, which allows this pathway to regulate a wide variety of cellular processes, including growth, proliferation, or differentiation. All p38α-mediated phosphorylations have been reported to occur on Ser or Thr residues, which are usually followed by a Pro residue ...
Natalia Trempolec +2 more
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Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. [PDF]
, 2014 Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age.
CONBOY, Irina M +6 more
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DENDRITIC CELL DIFFERENTIATION BLOCKED BY PRIMARY EFFUSION LYMPHOMA-RELEASED FACTORS IS PARTIALLY RESTORED BY INHIBITION OF P38 MAPK [PDF]
, 2010 To better understand the molecular mechanisms underlying the dendritic cell (DC) defects in cancer, we analyzed which signaling pathway is implicated in the abnormal monocyte differentiation into DC determined by the presence of Primary effusion lymphoma
CIRONE, Mara +6 more
core +2 more sources
International Journal of Molecular Sciences, 2023 The name extracellular signal-regulated kinase (ERK) was first used for a cell cycle regulating Ser/Thr protein kinase cloned in mammalian cells [...]
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An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development [PDF]
, 2007 Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer.
Elgort, Marc G. +7 more
core +2 more sources
The Ras/Raf/MAPK Pathway [PDF]
Journal of Thoracic Oncology, 2006 The Ras/Raf/MAPK pathway is probably the best characterized signal transduction pathway in cell biology. The function of this pathway is to transduce signals from the extracellular milieu to the cell nucleus where specific genes are activated for cell growth, division and differentiation.
Julian R. Molina, Alex A. Adjei
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International Journal of Molecular Sciences, 2022 Mitogen-activated protein kinase (MAPK) pathways are prominently involved in the onset and progression of cancer [...]
Rovida, Elisabetta, Tusa, Ignazia
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MAPK Signaling: Sho Business [PDF]
Current Biology, 2004 Sho1 is a membrane protein in yeast that activates the Hog MAPK signaling pathway in response to high osmolarity. An accumulating body of work has focused on Sho1 as a model to better understand the mechanisms that dictate signaling specificity.
Bruce T. Seet, Tony Pawson
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Control of Sty1 MAPK activity through stabilisation of the Pyp2 MAPK phosphatase [PDF]
Journal of Cell Science, 2013 In all eukaryotes tight control of mitogen-activated protein kinase (MAPK) activity plays an important role in modulating intracellular signalling in response to changing environments. The fission yeast MAPK Sty1 (also known as Spc1 or Phh1) is highly activated in response to a variety of external stresses. To avoid segregation of damaged organelles or
Kowalczyk, Katarzyna +4 more
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Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module [PDF]
, 2013 Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation.
Aberg +57 more
core +1 more source