Results 51 to 60 of about 736,655 (384)

PIK3CA mutations in advanced cancers: characteristics and outcomes. [PDF]

, 2012
PIK3CA mutations are frequently diagnosed in diverse cancers and may predict response to PI3K/AKT/mTOR inhibitors. It remains unclear whether they are associated with other characteristics.
Falchook, Gerald S, Fu, Siqing, Garrido-Laguna, Ignacio, Hong, David S, Janku, Filip, Kurzrock, Razelle, Lee, Jack J, Luthra, Rajyalakshmi, Moulder, Stacy L, Naing, Aung, Piha-Paul, Sarina A, Stepanek, Vanda M, Tsimberidou, Apostolia M, Wheler, Jennifer J   +13 more
core   +4 more sources

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, B.L., Okorji, U. P., Olajide, Olumayokun A.   +3 more
core   +2 more sources

Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke

Translational Neuroscience, 2022
Mitogen-activated protein kinase (MAPK) pathway is a major mechanism of acute brain damage in ischemic stroke. Pre-ischemic exercise is an effective method to reduce ischemic injury.
Gao Zhen-Kun, Shen Xin-Ya, Han Yu, Guo Yi-Sha, Li Kai, Bi Xia   +5 more
doaj   +1 more source

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Best, A.K., Columbus, L., Dunn, C.A., Isakson, B.E., Johnstone, S.R., Koval, M., Kroncke, B.M., Lampe, P.D., Lo, C.W., Mitchell, L.A., Nakamoto, R.K., Peskova, Y., Straub, A.C.   +12 more
core   +1 more source

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]

, 2010
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Acampora, Bialek, Bo Zhai, Despina Sitara, Dorothy Hu, El-Gharbawy, Jae-Hyuck Shim, Jin Mo Park, Jones, Karsenty, Laurie H. Glimcher, Lee, Matthew B. Greenblatt, Michael D. Schneider, Michelle Schweitzer, Min Xie, Mundlos, Raingeaud, Roger Davis, Roland Baron, Shim, Simon Arthur, Steven Gygi, Sutada Lotinun, Weiguo Zou, Yang, Yasuyo Sano   +26 more
core   +6 more sources

Macrophage depletion protects against endothelial dysfunction and cardiac remodeling in angiotensin II hypertensive mice

Clinical and Experimental Hypertension, 2021
Objective: Hypertension is associated with a low-grade systemic inflammation in cardiovascular system. Macrophage infiltration may initiate an inflammatory process that contributes to vascular and ventricular remodeling in hypertensive human and mice ...
Yuantong Tian, Jun Luo, Qian Xu, Yueyang Liu, Ruiping Cai, Ming-Sheng Zhou   +5 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway

Drug Design, Development and Therapy, 2021
Leyi Ma,1,* Fan Wu,1,* Qingqing Shao,1 Guang Chen,2 Lijun Xu,1 Fuer Lu1 1Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030 ...
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
doaj  

A novel polysaccharide from plant fermentation extracts and its immunomodulatory activity in macrophage RAW264.7 cells

Food and Agricultural Immunology, 2021
Plant fermentation extracts (PFEs) produced from fermenting various fruits and vegetables by microorganisms have traditionally been consumed as healthy beverages in Asia.
Yan Liang, Chunhua Liu, Shuxia Yan, Pu Wang, Binbin Wu, Chengzi Jiang, Xiaoqing Li, Yanwen Liu, Xiang Li   +8 more
doaj   +1 more source

SnapShot: p38 MAPK Substrates [PDF]

Cell, 2013
p38α mitogen-activated protein kinase (MAPK14) phosphorylates many downstream substrates, which allows this pathway to regulate a wide variety of cellular processes, including growth, proliferation, or differentiation. All p38α-mediated phosphorylations have been reported to occur on Ser or Thr residues, which are usually followed by a Pro residue ...
Natalia Trempolec, Natalia Dave-Coll, Angel R. Nebreda   +2 more
openaire   +2 more sources