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Role of lipids in the MAPK signaling pathway
Progress in Lipid Research, 2006The mitogen-activated protein kinase (MAPK) signaling pathway is activated in response to a variety of extracellular stimuli such as growth factor stimulation. The best-characterized MAPK pathway involves the sequential activation of Raf, MEK and ERK proteins, capable of regulating the gene expression required for cell proliferation.
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High-throughput approaches to dissecting MAPK signaling pathways
Methods, 2006With the development of genome-wide RNAi libraries, it is now possible to screen for novel components of mitogen-activated protein kinase (MAPK) pathways in cell culture. Although genetic dissection in model organisms and biochemical approaches in mammalian cells have been successful in identifying the core signaling cassettes of these pathways, high ...
Friedman, A., Perrimon, N.
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State machine modeling of MAPK signaling pathways
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Mitogen activated protein kinase (MAPK) signaling pathways are frequently deregulated in human cancers with potential involvement in most if not all cellular processes leading to tumorigenesis. Mathematical/computational models of MAPK signaling are indispensable to the study of pathway deregulation dynamics and their nonlinear effects on cell fate and
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MAPK signaling pathways in eye wounds: Multifunction and cooperation
Experimental Cell Research, 2017As is widely distributed in eukaryotic cells, the mitogen-activated protein kinase (MAPK) signaling pathway family plays an inevitable role in diverse cellular processes, being capable of responding to particular physiological reactions induced by multiple extracellular signals or stimuli, such as protean concentrations, ischemia/reperfusion, and ...
Boyuan, Yao +5 more
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The MAPK Signal Pathway Research and New Drug Discovery
2009 Ninth IEEE International Conference on Bioinformatics and BioEngineering, 2009MAPK cell signal transduction pathways determine the survival of the cells. If one can control this pathways, and then they will prohibit the proliferation of the cancer cells. Furthermore, they will heal the cancer smoothly. In order to attain this goal, we use lots of drugs to interact with MEK1 in MAPK, by using computer aided drug design to analyze
Po-Yuan Chen +4 more
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[MAPK signaling pathway and erectile dysfunction].
Zhonghua nan ke xue = National journal of andrology, 2018The MAPK signaling pathway plays a key role in the differentiation, proliferation and apoptosis of cells, and its family members mainly include extracellular signal-regulated kinase (ERK), stress-activated protein kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK). Recent studies have shown that the ERK, JNK and p38MAPK signaling pathways
Si-Xiang, Chen +2 more
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Regulation of cross-talk in yeast MAPK signaling pathways
Current Opinion in Microbiology, 2010MAP kinase (MAPK) modules are conserved three-kinase cascades that serve central roles in intracellular signal transduction in eukaryotic cells. MAPK pathways of different inputs and outputs use overlapping sets of signaling components. In yeast, for example, three MAPK pathways (pheromone response, filamentous growth response, and osmostress ...
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MAPK signaling pathway and endometriosis: what is the link?
Archives of Gynecology and Obstetrics, 2012Endometriosis is defined as the presence of endometrial tissue outside the uterus, predominantly on the ovary and pelvic peritoneum [1]. It occurs in approximately 10 % of women of reproductive age and, although it is a benign disease, it causes infertility and pelvic pain, compromising the quality of life [1].
Raffaella, Mormile, Giorgio, Vittori
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The Role of MAPK/p38 Signalling Pathway in Cancer
Journal of Clinical and Medical Research, 2023Cancer is one of the fatal diseases globally. It is unfortunate that despite many years of devoted studies towards finding a better therapeutic approach, the scourge of the disease has continued to rise with attendant mortalities. Many studies have been devoted to finding constructive clues to the pathways that are implicated in the onset and ...
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Wound signaling-coordination of the octadecanoid and MAPK pathways
Plant Physiology and Biochemistry, 2003Abstract Plants have developed integrated signaling networks that play a pivotal role in mediating the perception of and response to environmental factors, including wounding, a common stress. Wound signaling is known to involve at least two major signaling pathways—the octadecanoid and the MAPK pathways.
Randeep Rakwal, Ganesh Kumar Agrawal
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