Results 41 to 50 of about 170,469 (263)
Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]
, 2016 The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S. +3 more
core +1 more source
Prions activate a p38 MAPK synaptotoxic signaling pathway
PLOS Pathogens, 2018 Synaptic degeneration is one of the earliest pathological correlates of prion disease, and it is a major determinant of the progression of clinical symptoms. However, the cellular and molecular mechanisms underlying prion synaptotoxicity are poorly understood.
Cheng Fang +5 more
openaire +4 more sources
Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome [PDF]
, 2017 Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies.
Cannoodt, Robrecht +6 more
core +3 more sources
The expression of MAPK signaling pathways in conjunctivochalasis
International Journal of Ophthalmology, 2019 This study investigated the potential role of MAPK signaling pathways in conjunctivochalasis (CCH). Twenty loose conjunctival biopsy samples from 20 CCH and 15 conjunctival biopsy samples from 15 normal controls (CON) were collected. The conjunctival fibroblasts were cultured in vitro.
Yuan-Ling Jia +4 more
openaire +3 more sources
Molecular crosstalk between p70S6k and MAPK cell signaling pathways [PDF]
Biochemical and Biophysical Research Communications, 2002 We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, completely knocked out granulocyte-macrophage colony-stimulating factor (GM-CSF)-stimulated MAPK activity but also partially inactivated the ribosomal kinase p70S6K.
Jason A, Lehman +1 more
openaire +2 more sources
eLife, 2017 Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD+ biosynthetic enzyme NMNAT2 that inhibits ...
Lauren J Walker +5 more
doaj +1 more source
CRAF R391W is a melanoma driver oncogene. [PDF]
, 2016 Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known.
Atefi, Mohammad +11 more
core +3 more sources
Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCδ and p38 in Human Airway Epithelial Cells [PDF]
Clinical and Experimental Otorhinolaryngology, 2012 ObjectivesPhorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins. MUC16, one of the membrane-bound mucins, is produced in human airway epithelial cells.
Chang Hoon Bae +3 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mild hypoxia (5% O2) as well as FGFR1-induced activation of phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and MAPK signaling pathways markedly support pluripotency in human pluripotent stem cells (hPSCs).
Petr Fojtík +8 more
doaj +1 more source
Multiple Signals Converge on a Differentiation MAPK Pathway
PLoS Genetics, 2010 An important emerging question in the area of signal transduction is how information from different pathways becomes integrated into a highly coordinated response. In budding yeast, multiple pathways regulate filamentous growth, a complex differentiation response that occurs under specific environmental conditions.
Colin A Chavel +4 more
openaire +4 more sources