Results 91 to 100 of about 1,701,603 (284)

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

eLife, 2020
Filoviruses such as Ebola and Marburg virus bud from the host membrane as enveloped virions. This process is achieved by the matrix protein VP40. When expressed alone, VP40 induces budding of filamentous virus-like particles, suggesting that localization
William Wan, Mairi Clarke, Michael J Norris, Larissa Kolesnikova, Alexander Koehler, Zachary A Bornholdt, Stephan Becker, Erica Ollmann Saphire, John AG Briggs   +8 more
doaj   +1 more source

A platform trial design for preventive vaccines against Marburg virus and other emerging infectious disease threats

Clinical Trials, 2022
Background: The threat of a possible Marburg virus disease outbreak in Central and Western Africa is growing. While no Marburg virus vaccines are currently available for use, several candidates are in the pipeline.
I. Longini, Yang Yang, T. Fleming, C. Muñoz-Fontela, Rui Wang, S. Ellenberg, George Y. Qian, M. Halloran, M. Nason, V. Gruttola, S. Mulangu, Yunda Huang, C. Donnelly, A. H. Henao Restrepo   +13 more
semanticscholar   +1 more source

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index

Andrology, EarlyView.
Abstract Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age.
Richard Ivell, Bilal Tulumcu, Waleed Alhujaili, Ravinder Anand‐Ivell   +3 more
wiley   +1 more source

Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis [PDF]

, 2015
Background The Ebola virus disease outbreak that started in Western Africa in 2013 was unprecedented because it spread within densely populated urban environments and affected many thousands of people.
Baron, Bertherat, Blackley, Burke, Christie, De Roo, Faye, Formenty, Hall, Julii Brainard, Katherine Pond, Kelly Edmunds, Kunii, Lee Hooper, Mackay, McElroy, Moreau, Mupere, Nyenswah, Nyenswah, Nyenswah, Olabode, Paul R Hunter, Schibler, Victory, Vladyko, World Health Organization   +26 more
core   +1 more source

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections

Nature Communications, 2023
Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be elucidated. In
Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazimi   +23 more
doaj   +1 more source

Marburg Virus Disease – A Mini-Review

Journal of Experimental Biology and Agricultural Sciences, 2022
Marburg virus disease (MVD) is a highly fatal disease caused by the Marburg virus (MARV) which belongs to the family Filoviridae. The disease has been recently reported from Ghana, an African country, and nearly 15 outbreaks of MVD have been reported in ...
Sandip Chakraborty, Deepak Chandran, R. Mohapatra, M. Alagawany, M. I. Yatoo, Md. Aminul Islam, A. Sharma, K. Dhama   +7 more
semanticscholar   +1 more source

Impacts of bat use of anthropogenic structures on bats and humans

Conservation Biology, EarlyView.
Abstract Human‐induced landscape modifications and climate change are forcing wildlife into closer contact with humans as the availability of natural habitats decreases. Although the importance of anthropogenic structures for the conservation of species is widely recognized, negative narratives surrounding bats may impede conservation efforts in human ...
Ella A. Sippola, Joseph S. Johnson, Stefano Mammola, Grzegorz Apoznański, Ilze Brila, Ignacio Fernández Latapiat, Piia Lundberg, Mariia Matlova, Veronica Nanni, Reilly T. Jackson, Janette Perez‐Jimenez, Sonia Sánchez‐Navarro, Elena Tena, Tanya S. Troitsky, Thomas M. Lilley, Melissa B. Meierhofer   +15 more
wiley   +1 more source

Data from: A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection [PDF]

, 2017
The dataset contains findings and information from 51 seroprevelance studies performed from on samples collected from 1961 to 2016. These investigated 84 exposure-defined subgroups of subjects reported to have had no symptoms of EVD during the outbreak ...
Bower, Hilary, Glynn, Judith
core   +2 more sources

Ultrastructural Organization of Recombinant Marburg Virus Nucleoprotein: Comparison with Marburg Virus Inclusions

Journal of Virology, 2000
ABSTRACT HeLa cells expressing the recombinant Marburg virus (MBGV) nucleoprotein (NP) have been studied by immunoelectron microscopy. It was found that MBGV NPs assembled into large aggregates which were in close association with membranes of the rough endoplasmic reticulum.
Stephan Becker, Elke Mühlberger, Elena I. Ryabchikova, Larissa Kolesnikova   +3 more
openaire   +4 more sources

Crystal Structure of Marburg Virus VP24 [PDF]

Journal of Virology, 2014
ABSTRACT The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not.
Erica Ollmann Saphire, Dafna M. Abelson, Adrianna P. P. Zhang, Zachary A. Bornholdt   +3 more
openaire   +3 more sources