Marburg virus pathogenesis – differences and similarities in humans and animal models
Virology Journal, 2019 Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients ...
Kyle Shifflett, Andrea Marzi
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Viruses, 2018 Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a ...
Paul W. Blair +9 more
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From hybridomas to a robust microalgal-based production platform: molecular design of a diatom secreting monoclonal antibodies directed against the Marburg virus nucleoprotein [PDF]
, 2017 Background: The ideal protein expression system should provide recombinant proteins in high quality and quantity involving low production costs only. However, especially for complex therapeutic proteins like monoclonal antibodies many challenges remain ...
Becker, Stephan +7 more
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Microbial Biotechnology, Volume 18, Issue 9, September 2025.Human neurotropic viruses like SARS‐CoV‐2, HSV, HOPV and RSV pose significant risks due to their ability to invade and persist in the nervous system. Stapled peptides represent a promising therapeutic approach with enhanced stability, target affinity and bioavailability, emerging as an effective strategy for neutralising human neurotropic viruses ...
Sanskruti Patil +4 more
wiley +1 more source
Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
Cell Reports, 2020 Summary: Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species.
Yoshihiro Takadate +15 more
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Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry [PDF]
, 2015 Emerging viral diseases pose a threat to the global population as intervention strategies are mainly limited to basic containment due to the lack of efficacious and approved vaccines and antiviral drugs.
A De Milito +65 more
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Pathogenicity and virulence of Marburg virus
Virulence, 2022 Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death.
Mehedy Hasan Abir +13 more
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Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. [PDF]
, 2014 Budding of filoviruses, arenaviruses, and rhabdoviruses is facilitated by subversion of host proteins, such as Nedd4 E3 ubiquitin ligase, by viral PPxY late (L) budding domains expressed within the matrix proteins of these RNA viruses.
Davis, Benjamin +11 more
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Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology
Annals of the New York Academy of Sciences, Volume 1550, Issue 1, Page 151-172, August 2025.Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker +11 more
wiley +1 more source
Charakterisierung von Oligomerisierungsdomänen des Marburg-Virus Nukleoprotein und deren funktionelle Bedeutung [PDF]
, 2004 Das phosphorylierte Nukleokapsidprotein NP ist Hauptbestandteil des Marburg-Virus (MARV)-Nukleokapsidkomplexes (NC). Neben NP sind drei weitere virale Strukturproteine, VP35, VP30, L, und die genomische RNA in den NC eingebunden.
Di Carlo, Andrea +1 more
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