Results 101 to 110 of about 1,753 (136)

Neuroprotective Effect of Maresin-1 in Rotenone-Induced Parkinson's Disease in Rats: The Putative Role of the JAK/STAT Pathway. [PDF]

Neurochem Res
Khodir SA, Sweed EM, Faried MA, Abo Elkhair DM, Khalil MM, Afifi KH, El Agamy DF.   +6 more
europepmc   +1 more source

Maresin 1-LGR6 axis mitigates inflammation and posttraumatic osteoarthritis after transection of the anterior cruciate ligament in mice. [PDF]

Osteoarthritis Cartilage
Leite CBG, Fricke HP, Tavares LP, Nshimiyimana R, Mekhail J, Kilgallen E, Killick F, Whalen JD, Lehoczky JA, Serhan CN, Charles JF, Lattermann C.   +11 more
europepmc   +1 more source

Maresin-1 promotes neuroprotection and modulates metabolic and inflammatory responses in disease-associated cell types in preclinical models of multiple sclerosis. [PDF]

J Biol Chem
Zahoor I, Nematullah M, Ahmed ME, Fatma M, Sajad M, Ayasolla K, Cerghet M, Palaniyandi S, Ceci V, Carrera G, Buttari F, Centonze D, Mao-Draayer Y, Rattan R, Chiurchiù V, Giri S.   +15 more
europepmc   +1 more source

Maresin 1 alleviates neuroinflammation and cognitive decline in a mouse model of cecal ligation and puncture. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Li L, Xing M, Wang L, Zhao Y.
europepmc   +1 more source

Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway. [PDF]

J Inflamm Res
Sun M, Wang F, Li H, Li M, Wang Y, Wang C, Zhang Y, Zhang D, Li J, Yao S.   +9 more
europepmc   +1 more source

The Specialized Proresolving Mediator Maresin 1 Alleviated Neuropathic Pain Exacerbated by High-Fat Diet via Regulating Neuroinflammation

Pain Research and Management
Li Zhang, Ran Hu, Kexin Qin, Xue Wang, Chen Wu, Zichen Liu, Xiangqi Shao, Jianru Sun, Yang Liu, Saisong Xiao, Huilong Ren, Fan Liu, Guokai Liu   +12 more
doaj   +1 more source

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Maresin-1 resolution with RORα and LGR6

Progress in Lipid Research, 2020
Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
Dong-Soon Im
exaly   +3 more sources

Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway

American Journal of Physiology - Cell Physiology, 2021
The resolution of inflammation is closely linked with tissue repair. Recent studies have revealed that macrophages suppress inflammatory reactions by producing lipid mediators, called specialized proresolving mediators (SPMs); however, the biological significance of SPMs in tissue repair remains to be fully elucidated in the heart.
Tri Wahyuni, Anton Bahtiar, Masanori Obana   +2 more
exaly   +3 more sources

Stereoselective synthesis of maresin 1

Tetrahedron Letters, 2015
Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Trond Vidar Hansen, Marius Aursnes
exaly   +2 more sources

Synthesis of maresin 1 and (7S)-isomer

Tetrahedron Letters, 2014
Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa, Yuichi Kobayashi
exaly   +2 more sources