Results 101 to 110 of about 1,949 (158)

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

The FASEB Journal, 2012
Self‐resolving inflammatory exudates and lipid mediator metabolomics recently uncovered a new family of potent anti‐inflammatory and proresolving mediators biosynthesized by macrophages (MΦs), denoted maresins. Here we determined that maresin 1 (MaR1) produced by human MΦs from endogenous docosahexaenoic acid (DHA) matched ...
Charles N, Serhan, Jesmond, Dalli, Sergey, Karamnov, Alexander, Choi, Chul-Kyu, Park, Zhen-Zhong, Xu, Ru-Rong, Ji, Min, Zhu, Nicos A, Petasis   +8 more
openaire   +3 more sources

Does exercise enhance maresin-1 production? A new direction in metabolic anti-inflammatory research [PDF]

Exploration of Immunology
Obesity is a major global health challenge characterized by chronic low-grade inflammation and metabolic dysfunction. Among lipid-derived mediators involved in inflammation resolution, maresin-1 (MaR1)—a specialized pro-resolving mediator derived from ...
Mehran Alipour, Ayoub Saeidi, Maryam N. ALNasser, Khadija Ayed, Abdullah Almaqhawi, Keyvan Hejazi, Hassane Zouhal   +6 more
doaj   +1 more source

Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients.

, 2018
Inflammation always accompanies infection during sepsis. Mitochondrial dysfunction and the role of reactive oxygen species (ROS) produced by mitochondria have been proposed in the pathogenesis of sepsis.
Lu Bin, Binyu Ying, Li, Dan, Smith, Fang Gao, Ying, Binyu, Jiaqi Gu, Lin, Jing, Luo, Lingchun, Yan, Songfan, Hongxia Mei, Gu, Jiaqi, Bin, Lu, Mei, Hongxia, Bingbing Cao, Jin, Sheng-Wei, Lingchun Luo, Wang, Qian, Songfan Yan, Jing Lin, Sheng-Wei Jin, Cao, Bingbing, Qian Wang, Dan Li, Fang Gao Smith   +23 more
core   +1 more source

Maresin 1 activates brown adipocytes metabolism

, 2017
Brown adipose tissue (BAT) is the main site for adaptive heat production through non-shivering thermogenesis. BAT has been brought to attention, since it provides a protective mechanism against excessive body weight and fat mass accumulation. Recently, it has been suggested emerging roles of BAT activation in the regulation of metabolism, including ...
Laiglesia, Laura M., Escoté, Xavier, Valverde, Ángela M., Moreno-Aliaga, María Jesús   +3 more
openaire   +1 more source

Resolvin E1 and maresin 1 restore senescence-induced disruption of human periodontal ligament fibroblast function

BackgroundAging impairs the mechanisms that regulate inflammation, resulting in low-level chronic inflammation even in the absence of infection and increasing the risk of developing age-related illnesses.
Kantarcı, Alpdoğan, Ünlü, Özge, Güney, Zeliha   +2 more
core   +1 more source

Akut inmeli hastalarda Maresin-1'in inflamatuvar süreçlerle ilişkisi

Giriş ve Amaç: İnme, tüm dünyada ikincil ölüm nedeni olup, özellikle gelişmekte olan ülkelerde inme sonrası meydana gelen fonksiyonal kayıpların tedavileri sağlık harcamalarında önemli bir paya sahiptir.
El Moustafa, Houssein
core  

Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK–SERCA2b pathway

, 2018
Maresin 1 (MAR1), which is derived from docosahexaenoic acid biosynthesized by macrophages, has been reported to improve insulin resistance. Recently, it has been documented that MAR1 could ameliorate inflammation and insulin resistance in obese mice ...
Ji Hoon Jeong, Kim, Hyoung-Chun, Hyoung-Chun Kim, Tae Woo Jung, A.M. Abd El-Aty, Abd El-Aty, A. M., Jeong, Ji Hoon, Jung, Tae Woo   +7 more
core   +1 more source

Maresin 1 Ameliorates Lung Ischemia/Reperfusion Injury by Suppressing Oxidative Stress via Activation of the Nrf-2-Mediated HO-1 Signaling Pathway

, 2017
Lung ischemia/reperfusion (I/R) injury occurs in various clinical conditions and heavily damaged lung function. Oxidative stress reaction and antioxidant enzymes play a pivotal role in the etiopathogenesis of lung I/R injury.
Quanchao Sun, Jianjun Wang, You Wu, Feng Zhao   +3 more
core   +1 more source

Maresin 1 (MaR1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust

, 2013
BACKGROUND: Exposure to organic dust causes detrimental airway inflammation. Current preventative and therapeutic measures do not adequately treat resulting disease, necessitating novel therapeutic interventions.
Art J Heires, Romberger, Debra J., Nordgren, Tara M., Debra J Romberger, Heires, Art J., Tara M Nordgren, Todd A Wyatt, Wyatt, Todd A., Poole, Jill A., D Cerutis, LeVan, Tricia D., Jill A Poole, Cerutis, D. Roselyn, Tricia D LeVan   +13 more
core   +1 more source