Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis [PDF]
Frontiers in Pharmacology, 2021 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis; the latter is an essential factor for iNOS activation that contributes neuronal loss in Huntington’s disease (HD).
Aya M. Mustafa +3 more
doaj +2 more sources
Tubular Mas receptor mediates lipid-induced kidney injury [PDF]
Cell Death and Disease, 2021 Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood.
Yonglun Kong +10 more
doaj +2 more sources
Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita +14 more
doaj +2 more sources
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice [PDF]
Journal of NeuroinflammationBackground Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive decline, yet there is no effective treatment strategy to alleviate outcomes of these patients.
Xiangyang Deng +9 more
doaj +2 more sources
Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats [PDF]
Frontiers in Physiology, 2019 Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with cirrhosis. The renin-angiotensin system (RAS) plays an important role in splanchnic vasodilatation in cirrhosis.
Lakmie S. Gunarathne +3 more
doaj +2 more sources
Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy. [PDF]
PLoS ONE, 2013 Angiotensin-(1-7) [Ang-(1-7)] is a biologically active heptapeptide that may counterbalance the physiological actions of angiotensin II (Ang II) within the renin-angiotensin system (RAS). Here, we evaluated whether activation of the Mas receptor with the
Kátia Daniela Silveira +9 more
doaj +3 more sources
Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways [PDF]
Frontiers in Pharmacology, 2019 The MasR receptor (MasR) is an orphan G protein-coupled receptor proposed as a candidate for mediating the angiotensin (Ang)-converting enzyme 2-Ang-(1–7) protective axis of renin-angiotensin system.
Valeria Burghi +8 more
doaj +2 more sources
Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases. [PDF]
Cell Cycle, 2023 Molaei A, Molaei E, Hayes AW, Karimi G.
europepmc +3 more sources
Age- and Gender-Related Differences in Renal Vascular Responses to Angiotensin II in Rats: The Role of the Mas Receptor. [PDF]
J Aging Res, 2023 Eshraghi-Jazi F, Nematbakhsh M.
europepmc +3 more sources
Blockade of endothelial Mas receptor restores the vasomotor response to phenylephrine in human resistance arterioles pretreated with captopril and exposed to propofol. [PDF]
BMC Anesthesiol, 2022 Schulz ME +4 more
europepmc +3 more sources