Tubular Mas receptor mediates lipid-induced kidney injury [PDF]
Cell Death and Disease, 2021 Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood.
Yonglun Kong +10 more
doaj +5 more sources
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice [PDF]
Journal of NeuroinflammationBackground Intracerebral hemorrhage (ICH) is a devastating neurological disease causing severe sensorimotor dysfunction and cognitive decline, yet there is no effective treatment strategy to alleviate outcomes of these patients.
Xiangyang Deng +9 more
doaj +4 more sources
Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis [PDF]
Frontiers in Pharmacology, 2021 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis; the latter is an essential factor for iNOS activation that contributes neuronal loss in Huntington’s disease (HD).
Aya M. Mustafa +3 more
doaj +2 more sources
Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension [PDF]
PLoS ONEThe angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis plays an important role in the regulation of blood pressure. G protein-coupled receptor kinase 4 (GRK4) has attracted more attentions by modulating G protein-coupled receptors and ...
Lin Chen +7 more
doaj +3 more sources
Lisinopril prevents bullous pemphigoid induced by dipeptidyl peptidase 4 inhibitors via the Mas receptor pathway [PDF]
Frontiers in Immunology, 2023 Recent studies have suggested that dipeptidyl peptidase 4 (DPP4) inhibitors increase the risk of development of bullous pemphigoid (BP), which is the most common autoimmune blistering skin disease; however, the associated mechanisms remain unclear, and ...
Keisuke Nozawa +7 more
doaj +2 more sources
Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells. [PDF]
PLoS ONE, 2014 Renin-angiotensin system (RAS) plays a pivotal role in chronic kidney disease (CKD). Angiotensin converting enzyme-related carboxypeptidase 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis counteracts the deleterious actions of Ang II.
Hwee-Yeong Ng +6 more
doaj +3 more sources
Angiotensin-(1-7) alleviates acute lung injury by activating the Mas receptor in neutrophil. [PDF]
Ann Transl Med, 2022 Wang L +7 more
europepmc +3 more sources
Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways [PDF]
Frontiers in Pharmacology, 2019 The MasR receptor (MasR) is an orphan G protein-coupled receptor proposed as a candidate for mediating the angiotensin (Ang)-converting enzyme 2-Ang-(1–7) protective axis of renin-angiotensin system.
Valeria Burghi +8 more
doaj +2 more sources
Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats [PDF]
Frontiers in Physiology, 2019 Portal hypertension (PHT) resulting from splanchnic vasodilatation is a major cause of morbidity and mortality in patients with cirrhosis. The renin-angiotensin system (RAS) plays an important role in splanchnic vasodilatation in cirrhosis.
Lakmie S. Gunarathne +3 more
doaj +2 more sources
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling. [PDF]
Aging Cell, 2021 Dang R +7 more
europepmc +3 more sources