Results 21 to 30 of about 67,735 (314)

The role of receptor MAS in microglia-driven retinal vascular development [PDF]

Angiogenesis, 2019
The receptor MAS, encoded by Mas1, is expressed in microglia and its activation has been linked to anti-inflammatory actions. However, microglia are involved in several different processes in the central nervous system, including the promotion of angiogenesis.
Sébastien Foulquier, Vincenza Caolo, Geertje Swennen, Irina V. Milanova, Stefan Reinhold, Chiara Recarti, Natália Alenina, Michael Bäder, U. Muscha Steckelings, Tim Vanmierlo, Mark J. Post, Elizabeth A. V. Jones, Robert J. van Oostenbrugge, Thomas Unger   +13 more
openalex   +10 more sources

Mas Receptor Activation Slows Tumor Growth and Attenuates Muscle Wasting in Cancer. [PDF]

Cancer Res, 2019
Murphy KT, Hossain MI, Swiderski K, Chee A, Naim T, Trieu J, Haynes V, Read SJ, Stapleton DI, Judge SM, Trevino JG, Judge AR, Lynch GS.   +12 more
europepmc   +2 more sources

Renin-Angiotensin System: A Review of Historical Perspectives

Galician Medical Journal, 2023
The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova, Anna Zhuravlyova, Svitlana Ivanchenko   +2 more
doaj   +1 more source

Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release

Pharmaceutics, 2022
Heart failure (HF) causes decreased brain perfusion in older adults, and increased brain and systemic inflammation increases the risk of cognitive impairment and Alzheimer’s disease (AD).
David Encinas-Basurto, John P. Konhilas, Robin Polt, Meredith Hay, Heidi M. Mansour   +4 more
doaj   +1 more source

The MA Helix Is Important for Receptor Assembly and Function in the α4β2 nACh Receptor

Membranes, 2023
Pentameric ligand-gated ion channels (pLGICs) are expressed throughout the central and peripheral nervous systems of vertebrates and modulate many aspects of human health and disease. Recent structural and computational data indicate that cation-selective pLGICs contain a long helical extension (MA) of one of the transmembrane helices. The MA helix has
Dorottya I. Fricska, Susanne M. Mesoy, Sarah C. R. Lummis   +2 more
openaire   +4 more sources

TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor. [PDF]

Sci Rep, 2019
Klein S, Kleine CE, Pieper A, Granzow M, Gautsch S, Himmit M, Kahrmann K, Schierwagen R, Uschner FE, Magdaleno F, Naoum ME, Kristiansen G, Walther T, Bader M, Sauerbruch T, Trebicka J.   +15 more
europepmc   +3 more sources

Lateral Preoptic Area Neurons Activated by Angiotensin-(1–7) Increase Intravesical Pressure: A Novel Feature in Central Micturition Control

Frontiers in Physiology, 2021
Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure ...
Gustavo B. Lamy, Eduardo M. Cafarchio, Bárbara do Vale, Bruno B. Antonio, Daniel P. Venancio, Janaina S. de Souza, Rui M. Maciel, Gisele Giannocco, Gisele Giannocco, Patrik Aronsson, Monica A. Sato   +10 more
doaj   +1 more source

Accurate Evaluation on the Interactions of SARS-CoV-2 with Its Receptor ACE2 and Antibodies CR3022/CB6 [PDF]

CHIN.PHYS.LETT. Vol.38, No.1(2021)018701 Express Letter, 2021
The spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health crisis. The binding affinity of SARS-CoV-2 (in particular the receptor binding domain, RBD) to its receptor angiotensin converting enzyme 2 (ACE2) and the antibodies is of great importance in ...
arxiv   +1 more source

Endothelin-1 downregulates Mas receptor expression in human cardiomyocytes

Molecular Medicine Reports, 2013
Endothelin-1 (ET-1) and the renin-angiotensin system (RAS) are involved in the pathogenesis of cardiac dysfunction. The Mas receptor is a functional binding site for angiotensin (Ang)‑(1-7), which is now considered a critical component of the RAS and exerts cardioprotective effects.
Zhiheng Chen, Yamei Tang, Zuocheng Yang, Shaojun Liu, Yong Liu, Yan Li, Wei He   +6 more
openalex   +5 more sources

398 EVIDENCE OF A DIRECT MAS-AT2 RECEPTOR DIMERIZATION

Journal of Hypertension, 2012
Daniel C. Villela, Lisa Marie Munter, Gerd Multhaup, Magnus Mayer, Verena Benz, Pawel Namsolleck, Thomas Unger, Michael Bäder, Robson A.S. Santos, U. Muscha Steckelings   +9 more
openalex   +3 more sources