Results 21 to 30 of about 357,348 (338)

Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis. [PDF]

Int J Biol Sci
Tian S, Wu T, Zhang Z, Lv S, Ji X, Zhao Z, Ma X, Wang J, Bi Y.   +8 more
europepmc   +3 more sources

Angiotensin (1-7) Induces Mas Receptor Internalization [PDF]

Hypertension, 2011
Angiotensin (Ang) (1-7) is the endogenous ligand for the G protein–coupled receptor Mas, a receptor associated with cardiac, renal, and cerebral protective responses. Physiological evidence suggests that Mas receptor (MasR) undergoes agonist-dependent desensitization, but the underlying molecular mechanism regulating receptor ...
Mariela M, Gironacci, Hugo P, Adamo, Gerardo, Corradi, Robson A, Santos, Pablo, Ortiz, Oscar A, Carretero   +5 more
openaire   +3 more sources

Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release

Pharmaceutics, 2022
Heart failure (HF) causes decreased brain perfusion in older adults, and increased brain and systemic inflammation increases the risk of cognitive impairment and Alzheimer’s disease (AD).
David Encinas-Basurto, John P. Konhilas, Robin Polt, Meredith Hay, Heidi M. Mansour   +4 more
doaj   +1 more source

Interaction Between the Angiotensin-(1–7) Mas Receptor and the Dopamine D2 Receptor [PDF]

Hypertension, 2021
Ang (angiotensin) 1–7 MasR (Mas receptor) and D2R (dopamine D2 receptor) stimulation is coupled to anti-inflammatory responses. In the present work, we investigated the hypothesis that the anti-inflammatory action mediated by both receptors results from MasR-D2R heteromerization. Human monocyte (THP-1) cells differentiated to macrophages and exposed to
Natalia L. Rukavina Mikusic, Mauro G. Silva, Luciana R. Mazzitelli, Robson A.S. Santos, Karina A. Gómez, Hernán E. Grecco, Mariela M. Gironacci   +6 more
openaire   +4 more sources

Renin-Angiotensin System: A Review of Historical Perspectives

Galician Medical Journal, 2023
The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova, Anna Zhuravlyova, Svitlana Ivanchenko   +2 more
doaj   +1 more source

Angiotensin‐(1‐7) inhibits epidermal growth factor receptor transactivation via a Mas receptor‐dependent pathway [PDF]

British Journal of Pharmacology, 2011
BACKGROUND AND PURPOSE The transactivation of the epidermal growth factor (EGF) receptor appears to be an important central transduction mechanism in mediating diabetes‐induced vascular dysfunction. Angiotensin‐(1‐7) [Ang‐(1‐7)] via its Mas receptor can prevent the development of hyperglycaemia‐induced cardiovascular complications.
Saghir Akhtar, Mariam H.M. Yousif, Gursev S. Dhaunsi, Bindu Chandrasekhar, Omama Al‐Farsi, Ibrahim F. Benter   +5 more
openalex   +4 more sources

Lateral Preoptic Area Neurons Activated by Angiotensin-(1–7) Increase Intravesical Pressure: A Novel Feature in Central Micturition Control

Frontiers in Physiology, 2021
Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure ...
Gustavo B. Lamy, Eduardo M. Cafarchio, Bárbara do Vale, Bruno B. Antonio, Daniel P. Venancio, Janaina S. de Souza, Rui M. Maciel, Gisele Giannocco, Gisele Giannocco, Patrik Aronsson, Monica A. Sato   +10 more
doaj   +1 more source

Endothelin-1 downregulates Mas receptor expression in human cardiomyocytes

Molecular Medicine Reports, 2013
Endothelin-1 (ET-1) and the renin-angiotensin system (RAS) are involved in the pathogenesis of cardiac dysfunction. The Mas receptor is a functional binding site for angiotensin (Ang)‑(1-7), which is now considered a critical component of the RAS and exerts cardioprotective effects.
Zhiheng Chen, Yamei Tang, Zuocheng Yang, Shaojun Liu, Yong Liu, Yan Li, Wei He   +6 more
openalex   +5 more sources

A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality

Emerging Microbes and Infections, 2021
Since December 2019, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has changed our lives.
Serge Camelo, Mathilde Latil, Sam Agus, Waly Dioh, Stanislas Veillet, René Lafont, Pierre J. Dilda   +6 more
doaj   +1 more source

Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy. [PDF]

J Renin Angiotensin Aldosterone Syst, 2020
Ma YP, Yang Y, Jiang SM, Liu L, Zhang Z, Wang YN, Zou GM, Li WG.   +7 more
europepmc   +3 more sources