Results 1 to 10 of about 170,722 (268)

Tumor-Derived Extracellular Vesicles Induce CCL18 Production by Mast Cells: A Possible Link to Angiogenesis

Cells, 2022
Mast cells (MCs) function as a component of the tumor microenvironment (TME) and have both pro- and anti-tumorigenic roles depending on the tumor type and its developmental stage. Several reports indicate the involvement of MCs in angiogenesis in the TME
Irit Shefler, Pazit Salamon, Tali Zitman-Gal, Yoseph A. Mekori   +3 more
doaj   +1 more source

CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis

Frontiers in Immunology, 2023
The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo.
Geethani Bandara, Guido H. Falduto, Andrea Luker, Yun Bai, Annika Pfeiffer, Justin Lack, Dean D. Metcalfe, Ana Olivera   +7 more
doaj   +1 more source

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Cells, 2021
Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD).
Magda Babina, Zhao Wang, Kristin Franke, Torsten Zuberbier   +3 more
doaj   +1 more source

Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production

Haematologica, 2020
Persistent dysregulation of IL-6 production and signaling have been implicated in the pathology of various cancers. In systemic mastocytosis, increased serum levels of IL-6 associate with disease severity and progression, although the mechanisms involved
Araceli Tobío, Geethani Bandara, Denise A. Morris, Do-Kyun Kim, Michael P. O’Connell, Hirsh D. Komarow, Melody C. Carter, Daniel Smrz, Dean D. Metcalfe, Ana Olivera   +9 more
doaj   +1 more source

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation

Nature Communications, 2021
Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected ...
Do-Kyun Kim, Geethani Bandara, Young-Eun Cho, Hirsh D. Komarow, Danielle R. Donahue, Baktiar Karim, Moon-Chang Baek, Ho Min Kim, Dean D. Metcalfe, Ana Olivera   +9 more
doaj   +1 more source

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production. [PDF]

PLoS ONE, 2015
Current clinical and translational studies have shown that mast cell plays a pivotal role in multiple fibrotic diseases including scleroderma. However, the lack of mature human mast cell culture model exhibits a major obstacle for further dissection of ...
Gu Ningyan, Yao Xu, Shi Hongfei, Chen Jingjing, Chen Min   +4 more
doaj   +1 more source

Adult-onset mast cell activation syndrome following scombroid poisoning: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Mast cells are closely associated with epithelium, serving as sentinels responsible for the recognition of tissue injury and coordination of the initial inflammatory response.
Isabelle Brock, Nicole Eng, Anne Maitland   +2 more
doaj   +1 more source

Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome

International Journal of Infectious Diseases, 2020
Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2.
Lawrence B. Afrin, Leonard B. Weinstock, Gerhard J. Molderings   +2 more
doaj   +1 more source

Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT

Frontiers in Immunology, 2018
Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara, Rosa Muñoz-Cano, Araceli Tobío, Yuzhi Yin, Hirsh D. Komarow, Avanti Desai, Dean D. Metcalfe, Ana Olivera   +7 more
doaj   +1 more source