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Cardiovascular manifestations in mast cell activation disease: key insights for cardiologists and angiologists [PDF]
Frontiers in Cardiovascular MedicineMast cell activation disease is a genetic disease entity characterized by a very pronounced clinical symptomatology with potential manifestations in virtually every organ and tissue.
Wolfgang Taumann, Gerhard J. Molderings
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Mast Cells: A New Frontier for Cancer Immunotherapy
Cells, 2021 Mast cells are unique tissue-resident immune cells of the myeloid lineage that have long been implicated in the pathogenesis of allergic and autoimmune disorders. More recently, mast cells have been recognized as key orchestrators of anti-tumor immunity,
Jake N. Lichterman, Sangeetha M. Reddy
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Cells, 2022 Mast cells (MCs) function as a component of the tumor microenvironment (TME) and have both pro- and anti-tumorigenic roles depending on the tumor type and its developmental stage. Several reports indicate the involvement of MCs in angiogenesis in the TME
Irit Shefler +3 more
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Frontiers in Immunology, 2023 The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo.
Geethani Bandara +7 more
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Cells, 2021 Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD).
Magda Babina +3 more
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Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production
Haematologica, 2020 Persistent dysregulation of IL-6 production and signaling have been implicated in the pathology of various cancers. In systemic mastocytosis, increased serum levels of IL-6 associate with disease severity and progression, although the mechanisms involved
Araceli Tobío +9 more
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The ingenious mast cell: Contemporary insights into mast cell behavior and function
Allergy. European Journal of Allergy and Clinical Immunology, 2020 Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood.
Joakim S. Dahlin +5 more
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Nature Communications, 2021 Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected ...
Do-Kyun Kim +9 more
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Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI‐mediated signaling
Allergy. European Journal of Allergy and Clinical Immunology, 2020 Short‐chain fatty acids (SCFAs) are fermented dietary components that regulate immune responses, promote colonic health, and suppress mast cell–mediated diseases.
Jelle Folkerts +12 more
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Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins
Frontiers in Immunology, 2021 Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West +8 more
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