Results 91 to 100 of about 304,209 (218)

Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

JCI Insight, 2021
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease.
Xiaomei Kong, William C. Bennett, Corey M. Jania, Kelly D. Chason, Zachary German, Jennifer Adouli, Samuel D. Budney, Brandon T. Oby, Catharina van Heusden, Eduardo R. Lazarowski, Ilona Jaspers, Scott H. Randell, Barry A. Hedgespeth, Glenn Cruse, Xiaoyang Hua, Stephen A. Schworer, Gregory J. Smith, Samir N.P. Kelada, Stephen L. Tilley   +18 more
doaj   +1 more source

Protein Disulfide Isomerases Regulate IgE-Mediated Mast Cell Responses and Their Inhibition Confers Protective Effects During Food Allergy

Frontiers in Immunology, 2020
The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles during protein folding, maintaining cellular function and viability.
Dylan Krajewski, Stephanie H. Polukort, Justine Gelzinis, Jeffrey Rovatti, Edwin Kaczenski, Christine Galinski, Megan Pantos, Nickul N. Shah, Nickul N. Shah, Sallie S. Schneider, Sallie S. Schneider, Daniel R. Kennedy, Clinton B. Mathias, Clinton B. Mathias   +13 more
doaj   +1 more source

MMP-1 activation contributes to airway smooth muscle growth and asthma severity [PDF]

, 2016
Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity.
Berger P, Catherine Reynolds, Charlotte K. Billington, Christopher Philp, David J. Jackson, Debbie Clements, Dominick E. Shaw, Hasaneen NA, Irshad Soomro, Johnson S, Karlinsky JB, Naveed S, Rajah R, Sebastian L. Johnston, Shams-un-nisa Naveed, Simon R. Johnson, Timothy W. Harrison   +16 more
core   +2 more sources

Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming

Cell Reports, 2015
Mast cells are critical promoters of adaptive immunity in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood.
Jan Dudeck, Shanawaz Mohammed Ghouse, Christian H.K. Lehmann, Anja Hoppe, Nadja Schubert, Sergei A. Nedospasov, Diana Dudziak, Anne Dudeck   +7 more
doaj   +1 more source

Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation [PDF]

, 2009
BACKGROUND: Mast cell chymase may participate in the pathogenesis of human abdominal aortic aneurysm (AAA), yet a direct contribution of this serine protease to AAA formation remains unknown.
Ennis, Terri L, Gurish, Michael F, He, Aina, Libby, Peter, Lindholt, Jes Sanddal, Liu, Jian, Pejler, Gunnar, Shi, Guo-Ping, Stevens, Richard Lee, Sukhova, Galina K, Sun, Jiusong, Thompson, Robert W., Zhang, Jie, Åbrink, Magnus   +13 more
core   +1 more source

Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challenging Experience and Review

Case Reports in Hematology, 2019
Background. Mast cell leukaemia is a unique disease among hematopoietic neoplasms, being one of the rarest leukaemia subtypes. In addition, its prompt diagnosis is usually challenging.
Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Amna Gameil, Mohamed Yassin, Halima El-Omri   +5 more
doaj   +1 more source

Mast Cell Regulation of the Immune Response [PDF]

, 2009
Mast cells are well known as principle effector cells of type I hypersensitivity responses. Beyond this role in allergic disease, these cells are now appreciated as playing an important role in many inflammatory conditions.
Johanna K. Morales, John J. Ryan, Josephine F. A. Fernando, Matthew R. Macey, Yves T. Falanga   +4 more
core   +2 more sources

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice [PDF]

, 2014
Abdominal aortic aneurysm (AAA), an inflammatory disease, involves leukocyte recruitment, immune responses, inflammatory cytokine production, vascular remodeling, neovascularization, and vascular cell apoptosis, all of which contribute to aortic ...
Baxter, B. Timothy, Ennis, Terri L., Knispel, Rebecca, Libby, Peter, Liu, Jianming, MacFarlane, Lindsey Adair, Shi, Guo-Ping, Sukhova, Galina K., Sun, Chongxiu, Sun, Jiusong, Thompson, Robert W., Wolters, Paul J., Xiong, Wanfen, Yang, Min, Zhang, Yadong   +14 more
core   +1 more source

Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation[S]

Journal of Lipid Research, 2013
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression.
Martine Bot, Saskia C.A. de Jager, Luke MacAleese, H. Maxime Lagraauw, Theo J.C. van Berkel, Paul H.A. Quax, Johan Kuiper, Ron M.A. Heeren, Erik A.L. Biessen, Ilze Bot   +9 more
doaj   +1 more source

Choroidal mast cells in retinal pathology: a potential target for intervention. [PDF]

, 2015
Mast cells are important in the initiation of ocular inflammation, but the consequences of mast cell degranulation on ocular pathology remain uncharacterized.
Behar-Cohen, F., Bergin, C., Besson-Lescure, B., Bousquet, E., Castaneda, B., de Kozak, Y., Lorena, V., Naud, M.C., Thillaye-Goldenberg, B., Zhao, M.   +9 more
core   +1 more source