Results 91 to 100 of about 10,756,993 (383)
Molecular Oncology, 2020 Mast cells are a major component of the immune microenvironment in tumour tissues and modulate tumour progression by releasing pro‐tumorigenic and antitumorigenic molecules.
Xuanwen Bao +3 more
doaj +1 more source
Mast-cell infiltration of airway smooth muscle in asthma.
New England Journal of Medicine, 2002 BACKGROUND Asthma and eosinophilic bronchitis are characterized by similar inflammatory infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from asthma in that there is no variable airflow obstruction or airway ...
C. Brightling +5 more
semanticscholar +1 more source
COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation
The Neuroscientist, 2020 Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new pandemic infectious disease that originated in China. COVID-19 is a global public health emergency of international concern.
D. Kempuraj +10 more
semanticscholar +1 more source
Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells [PDF]
, 2015 Background: Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking ...
A Ito +26 more
core +2 more sources
Advanced Science, EarlyView.Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu +14 more
wiley +1 more source
Staphylococcus δ-toxin promotes mouse allergic skin disease by inducing mast cell degranulation
Nature, 2013 Atopic dermatitis is a chronic inflammatory skin disease that affects 15–30% of children and approximately 5% of adults in industrialized countries. Although the pathogenesis of atopic dermatitis is not fully understood, the disease is mediated by an ...
Y. Nakamura +12 more
semanticscholar +1 more source
MODULATING THE INNATE IMMUNE RESPONSE TO ELECTROSPUN SCAFFOLDS AND POLYMER DEGRADATIVE BYPRODUCTS [PDF]
, 2017 Implanted biomaterials often induce inflammation that frequently leads to the foreign body response, fibrosis, and the failure of the implant. Thus, it is important to evaluate how cells interact with materials to promote a more regenerative response. It
Abebayehu, Daniel
core +2 more sources
Choroidal mast cells in retinal pathology: a potential target for intervention. [PDF]
, 2015 Mast cells are important in the initiation of ocular inflammation, but the consequences of mast cell degranulation on ocular pathology remain uncharacterized.
Behar-Cohen, F. +9 more
core +1 more source
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer
Advanced Science, EarlyView.Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang +16 more
wiley +1 more source