Results 101 to 110 of about 10,756,993 (383)

Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer.

Cancer Research, 2013
Pancreatic ductal adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment, which includes cancer-associated fibroblasts [also known as pancreatic stellate cells (PSC)] and immune cells that provide a fibrotic niche that impedes successful
Ying Ma, R. Hwang, C. Logsdon, S. Ullrich   +3 more
semanticscholar   +1 more source

Comparative analysis of mast cell count in normal oral mucosa and oral pyogenic granuloma [PDF]

, 2011
Introduction: Mast cells are large granular cells that arise from a multipotent CD 34+ precursor in the bone marrow normally distributed throughout connective tissues.
Dahiya, Parveen, Kamal, Reet, Palaskar, Sangeeta, Shetty, V.P.   +3 more
core   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel. [PDF]

, 2009
BACKGROUND: Advanced age is associated with a reduction in clinical visceral pain perception. However, the underlying mechanisms remain largely unknown.
Firth, Saffrey, Lasch, Lagier, Gururatsakul, Santer, Gabella, El-Salhy, Souza, Phillips, Keating, Lee, Cremon, Barbara, Leri, Drossman, Camilleri, Fioramonti, Schwetz, Lindstrom, Jiang, Lynn, Brierley, Feng, Brookes, Brierley, Brierley, Bernard, Phillips, Phillips, Vega, Peck, Bergman, Csiszar, Giunta, Magrone, Stead, Stead, Naukkarinen, Pang, Wheatcroft   +40 more
core   +3 more sources

Mast cell responses to danger signals [PDF]

, 2012
Detecting and responding to danger is a paramount function of the immune system. Compounds heralding danger can be divided into two groups: exogenous and endogenous danger signals.
Enoksson, Mattias
core   +1 more source

Mast cell activation contributes to sickle cell pathobiology and pain in mice.

Blood, 2013
Sickle cell anemia (SCA) is an inherited disorder associated with severe lifelong pain and significant morbidity. The mechanisms of pain in SCA remain poorly understood.
Lucile Vincent, Derek Vang, J. Nguyen, Mihir Gupta, K. Luk, M. Ericson, D. Simone, K. Gupta   +7 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

JCI Insight, 2021
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease.
Xiaomei Kong, William C. Bennett, Corey M. Jania, Kelly D. Chason, Zachary German, Jennifer Adouli, Samuel D. Budney, Brandon T. Oby, Catharina van Heusden, Eduardo R. Lazarowski, Ilona Jaspers, Scott H. Randell, Barry A. Hedgespeth, Glenn Cruse, Xiaoyang Hua, Stephen A. Schworer, Gregory J. Smith, Samir N.P. Kelada, Stephen L. Tilley   +18 more
doaj   +1 more source

Protein Disulfide Isomerases Regulate IgE-Mediated Mast Cell Responses and Their Inhibition Confers Protective Effects During Food Allergy

Frontiers in Immunology, 2020
The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles during protein folding, maintaining cellular function and viability.
Dylan Krajewski, Stephanie H. Polukort, Justine Gelzinis, Jeffrey Rovatti, Edwin Kaczenski, Christine Galinski, Megan Pantos, Nickul N. Shah, Nickul N. Shah, Sallie S. Schneider, Sallie S. Schneider, Daniel R. Kennedy, Clinton B. Mathias, Clinton B. Mathias   +13 more
doaj   +1 more source