Results 101 to 110 of about 10,829,007 (362)

Evidence for dysbiosis in the gut microbiome of patients with systemic mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Limited research studies have investigated the role of the gut microbiome in systemic mastocytosis (SM), which is characterized by an aberrant expansion of clonal mast cells in specific tissues including the skin, marrow, liver, and the ...
Lauren E. Krausfeldt, PhD, Vivian Cao, MS, Richard Rodrigues, PhD, Wendy A. Henderson, PhD, Robin Eisch, RN, Linda M. Scott, LNP, Dean D. Metcalfe, MD, MS, Hirsh D. Komarow, MD   +7 more
doaj   +1 more source

Oral Immunotherapy and Basophil and Mast Cell Reactivity in Food Allergy [PDF]

, 2020
Anuya Paranjape, Mindy Tsai, Kaori Mukai, Ramona A. Hoh, Shilpa A. Joshi, R. Sharon Chinthrajah, Kari C. Nadeau, Scott D. Boyd, Stephen J. Galli   +8 more
openalex   +1 more source

Lipoleiomyoma With Bizarre Nuclei and Abundant Mast Cells [PDF]

, 2023
Rana K Alrasheed, Mohammed Abdelatif M Elhassan, Muradi A Murad   +2 more
openalex   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Banana lectin (BanLec) induces non-specific activation of basophils and mast cells in atopic subjects [PDF]

, 2018
N. Krithika, Siddanakoppalu N. Pramod, P A Mahesh, Yeldur P. Venkatesh   +3 more
openalex   +1 more source

Safety of COVID‐19 vaccination in children with prior allergic reactions or mast cell disorders [PDF]

, 2023
Rishabh Kulkarni, Annabelle Arnold, Adrian Buzynski, Michaela Lucas   +3 more
openalex   +1 more source

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

Nature Communications, 2012
Mast cells are known effector cells in allergic and inflammatory diseases, but their precise roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in intestinal inflammation is mediated by ATP-reactive P2X7 ...
Y. Kurashima, T. Amiya, T. Nochi, Kumiko Fujisawa, Takeshi Haraguchi, H. Iba, H. Tsutsui, Shintaro Sato, S. Nakajima, H. Iijima, M. Kubo, J. Kunisawa, H. Kiyono   +12 more
semanticscholar   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo

Scientific Reports, 2017
Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation.
Hanna Pettersson, Behdad Zarnegar, Annika Westin, Viktor Persson, Christiane Peuckert, Jörgen Jonsson, Jenny Hallgren, Klas Kullander   +7 more
doaj   +1 more source