Results 11 to 20 of about 10,829,007 (362)
Mast Cell Activation Disorders [PDF]
Medicina, 2021 Background and Objectives: Mast cell disorders comprise a wide spectrum of syndromes caused by mast cells’ degranulation with acute or chronic clinical manifestations.
Arianna Giannetti +4 more
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Blood, 2013 Mast cell leukemia (MCL) is a very rare form of aggressive systemic mastocytosis accounting for < 1% of all mastocytosis. It may appear de novo or secondary to previous mastocytosis and shares more clinicopathologic aspects with systemic mastocytosis ...
S. Georgin-lavialle +5 more
semanticscholar +3 more sources
Current Gastroenterology Reports, 2010 Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity.
Terez, Shea-Donohue +3 more
openaire +2 more sources
The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production. [PDF]
PLoS ONE, 2015 Current clinical and translational studies have shown that mast cell plays a pivotal role in multiple fibrotic diseases including scleroderma. However, the lack of mature human mast cell culture model exhibits a major obstacle for further dissection of ...
Gu Ningyan +4 more
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Mast cells are closely associated with epithelium, serving as sentinels responsible for the recognition of tissue injury and coordination of the initial inflammatory response.
Isabelle Brock +2 more
doaj +1 more source
Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome
International Journal of Infectious Diseases, 2020 Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2.
Lawrence B. Afrin +2 more
doaj +1 more source
Frontiers in Immunology, 2018 Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara +7 more
doaj +1 more source
Genome Biology, 2015 Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly non-zero or non-detectable.
Greg Finak +11 more
semanticscholar +1 more source
House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation
Nature Immunology, 2019 Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs).
N. Serhan +13 more
semanticscholar +1 more source
Human placental extract suppresses mast cell activation and induces mast cell apoptosis
Allergy, Asthma & Clinical Immunology, 2023 Background Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been ...
Tongqian Wu +8 more
doaj +1 more source