Results 11 to 20 of about 337,935 (358)
MiR-221 influences effector functions and actin cytoskeleton in mast cells. [PDF]
PLoS ONE, 2011 Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost completely unexplored.
Ramon J Mayoral +6 more
doaj +21 more sources
Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]
PeerJ, 2015 Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Junxi Wu +9 more
doaj +6 more sources
Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome
International Journal of Infectious Diseases, 2020 Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2.
Lawrence B. Afrin +2 more
doaj +1 more source
Frontiers in Immunology, 2018 Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara +7 more
doaj +1 more source
The mast cell and mast cell disease
Journal of the American Academy of Dermatology, 1995 Mast cell disease or mastocytosis is a heterogeneous group of clinical disorders characterized by the proliferation and accumulation of mast cells in a variety of tissues, most often the skin. The signs and symptoms of mast cell disease are varied, dependent on the localization of mast cells in different organs and the local and systemic effects of ...
J, Longley, T P, Duffy, S, Kohn
openaire +2 more sources
Mast cell clones: a model for the analysis of cellular maturation. [PDF]
, 1982 Cloned mouse mast cells resemble, by ultrastructure, immature mast cells observed in vivo. These mast cell clones can be grown in the absence of any other cells, facilitating direct investigations of their biochemistry and function.
Cantor, H +10 more
core +2 more sources
Human placental extract suppresses mast cell activation and induces mast cell apoptosis
Allergy, Asthma & Clinical Immunology, 2023 Background Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been ...
Tongqian Wu +8 more
doaj +1 more source
Gastrointestinal Disorders, 2021 The aim was to assess methods utilized in assessing mast cell involvement in functional abdominal pain disorders (FAPDs), specifically to describe variability in methods utilized to assess both mast cell density and activation and determine if a ...
Hunter Friesen +4 more
doaj +1 more source
Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies [PDF]
, 2014 This study sought to correlate faecal and urinary N-methylhistamine (NMH) concentrations with resting versus degranulated duodenal mast cell numbers in dogs with chronic enteropathies (CE), and investigate correlations between intestinal mast cell ...
Allenspach, K +5 more
core +3 more sources
Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
Frontiers in Cell and Developmental Biology, 2021 Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener +14 more
doaj +1 more source