Results 11 to 20 of about 10,756,993 (383)
Future Needs in Mast Cell Biology [PDF]
International Journal of Molecular Sciences, 2019 The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct “subpopulations” of mast cells based on a relatively small ...
G. Varricchi +3 more
semanticscholar +4 more sources
Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]
PeerJ, 2015 Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Junxi Wu +9 more
doaj +6 more sources
Mast cell glycosaminoglycans [PDF]
Glycoconjugate Journal, 2016 Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or dermatan sulphate. Tight packing of granule proteins is dependent on the presence of serglycin carrying these GAGs.
B. Mulloy, R. Lever, C. P. Page
openaire +11 more sources
MiR-221 influences effector functions and actin cytoskeleton in mast cells. [PDF]
PLoS ONE, 2011 Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost completely unexplored.
Ramon J Mayoral +6 more
doaj +5 more sources
Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis [PDF]
, 2016 Neoplastic accumulation of mast cells in systemic mastocytosis (SM) associates with activating mutations in the receptor tyrosine kinase KIT. Constitutive activation of tyrosine kinase oncogenes has been linked to imbalances in oxidant/antioxidant ...
Bai, Yun +10 more
core +13 more sources
International Journal of Immunopathology and Pharmacology, 2010 The immune system is a highly complex, intricately regulated group of cells whose integrated function is essential to health. The mast cell inflammatory response is characterized by an early phase with massive discharge of mediators stored in cytoplasmic secretory granules.
Anogeianaki A +19 more
openaire +8 more sources
The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production. [PDF]
PLoS ONE, 2015 Current clinical and translational studies have shown that mast cell plays a pivotal role in multiple fibrotic diseases including scleroderma. However, the lack of mature human mast cell culture model exhibits a major obstacle for further dissection of ...
Gu Ningyan +4 more
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Mast cells are closely associated with epithelium, serving as sentinels responsible for the recognition of tissue injury and coordination of the initial inflammatory response.
Isabelle Brock +2 more
doaj +1 more source
Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins
Frontiers in Immunology, 2021 Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West +8 more
doaj +1 more source
Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
Frontiers in Cell and Developmental Biology, 2021 Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener +14 more
doaj +1 more source