Results 21 to 30 of about 10,829,007 (362)
Gastrointestinal Disorders, 2021 The aim was to assess methods utilized in assessing mast cell involvement in functional abdominal pain disorders (FAPDs), specifically to describe variability in methods utilized to assess both mast cell density and activation and determine if a ...
Hunter Friesen +4 more
doaj +1 more source
Mast cell glycosaminoglycans [PDF]
Glycoconjugate Journal, 2016 Mast cells contain granules packed with a mixture of proteins that are released on degranulation. The proteoglycan serglycin carries an array of glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or dermatan sulphate. Tight packing of granule proteins is dependent on the presence of serglycin carrying these GAGs.
B. Mulloy, R. Lever, C. P. Page
openaire +6 more sources
Frontiers in Immunology, 2021 Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the nasal route ...
Brandi T. Johnson-Weaver +10 more
doaj +1 more source
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Nature Communications, 2019 The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast cell accumulation in murine and human intestinal-type gastric cancer.
M. Eissmann +16 more
semanticscholar +1 more source
Mast Cell Responses to Viruses and Pathogen Products
International Journal of Molecular Sciences, 2019 Mast cells are well accepted as important sentinel cells for host defence against selected pathogens. Their location at mucosal surfaces and ability to mobilize multiple aspects of early immune responses makes them critical contributors to effective ...
J. Marshall +2 more
semanticscholar +1 more source
British Journal of Haematology, 2005 In May 2003, a 65-year-old white male presented with weight loss, night sweats, pruritus, diarrhoea, and joint pain. Radiographic studies showed hepatosplenomegaly, abdominal lymphadenopathy and both osteoblastic and osteolytic bone lesions. Bone marrow biopsy showed extensive mast cell infiltration and effacement of marrow structure with reduction of ...
Olaf, Penack +2 more
openaire +2 more sources
Acta Veterinaria Scandinavica, 2022 Background Mast cell density has been shown to have both enhancing and inhibiting effects on tumour progression and the ability to predict breast cancer behaviour in humans. However, prognostic results have been contradictory.
Simona Sakalauskaitė +3 more
doaj +1 more source
Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
Frontiers in Cell and Developmental Biology, 2021 Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener +14 more
doaj +1 more source
Future Needs in Mast Cell Biology
International Journal of Molecular Sciences, 2019 The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct “subpopulations” of mast cells based on a relatively small ...
G. Varricchi +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2018 Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body.
E. Thangam +7 more
semanticscholar +1 more source