Results 21 to 30 of about 304,209 (218)
Frontiers in Immunology, 2021 Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the nasal route ...
Brandi T. Johnson-Weaver +10 more
doaj +1 more source
Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3. [PDF]
, 2008 Systemic mastocytoses represent neoplastic proliferations of mast cells. In about 20% of cases systemic mastocytoses are accompanied by clonal haematopoietic non-mast cell-lineage disorders, most commonly myeloid neoplasms.
Dirnhofer, S. +7 more
core +1 more source
Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. [PDF]
, 2017 Aims: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis.
Kennedy, Simon +3 more
core +8 more sources
British Journal of Haematology, 2005 In May 2003, a 65-year-old white male presented with weight loss, night sweats, pruritus, diarrhoea, and joint pain. Radiographic studies showed hepatosplenomegaly, abdominal lymphadenopathy and both osteoblastic and osteolytic bone lesions. Bone marrow biopsy showed extensive mast cell infiltration and effacement of marrow structure with reduction of ...
Olaf, Penack +2 more
openaire +2 more sources
Acta Veterinaria Scandinavica, 2022 Background Mast cell density has been shown to have both enhancing and inhibiting effects on tumour progression and the ability to predict breast cancer behaviour in humans. However, prognostic results have been contradictory.
Simona Sakalauskaitė +3 more
doaj +1 more source
Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
Frontiers in Cell and Developmental Biology, 2021 Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener +14 more
doaj +1 more source
Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62 [PDF]
, 2013 ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc휀RI-mediated mast cell responses.
Al-Riyami, Lamyaa +7 more
core +2 more sources
An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]
, 2018 Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura +3 more
core +2 more sources
siRNA knockdown of SPHK1 in vivo protects mice from systemic, type-I Allergy. [PDF]
, 2007 Systemic anaphylaxis is considered to be a typical immediate hypersensitivity response, determined by the activation of immune cells, via antigen-induced aggregation of IgE-sensitized FcεRI cells.
Alirio Jose A. J. Melendez +2 more
core +2 more sources
BMC Immunology, 2010 Background Mast cells have recently gained new importance as immunoregulatory cells that are involved in numerous pathological processes. One result of these processes is an increase in mast cell numbers at peripheral sites.
Pastor Maria +8 more
doaj +1 more source