Results 21 to 30 of about 10,756,993 (383)
Frontiers in Immunology, 2018 Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara +7 more
doaj +1 more source
Gastrointestinal Disorders, 2021 The aim was to assess methods utilized in assessing mast cell involvement in functional abdominal pain disorders (FAPDs), specifically to describe variability in methods utilized to assess both mast cell density and activation and determine if a ...
Hunter Friesen +4 more
doaj +1 more source
Human placental extract suppresses mast cell activation and induces mast cell apoptosis
Allergy, Asthma & Clinical Immunology, 2023 Background Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been ...
Tongqian Wu +8 more
doaj +1 more source
Genome Biology, 2015 Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly non-zero or non-detectable.
Greg Finak +11 more
semanticscholar +1 more source
Mast cell clones: a model for the analysis of cellular maturation. [PDF]
, 1982 Cloned mouse mast cells resemble, by ultrastructure, immature mast cells observed in vivo. These mast cell clones can be grown in the absence of any other cells, facilitating direct investigations of their biochemistry and function.
Cantor, H +10 more
core +2 more sources
Frontiers in Immunology, 2021 Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the nasal route ...
Brandi T. Johnson-Weaver +10 more
doaj +1 more source
House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation
Nature Immunology, 2019 Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs).
N. Serhan +13 more
semanticscholar +1 more source
The mast cell and mast cell disease
Journal of the American Academy of Dermatology, 1995 Mast cell disease or mastocytosis is a heterogeneous group of clinical disorders characterized by the proliferation and accumulation of mast cells in a variety of tissues, most often the skin. The signs and symptoms of mast cell disease are varied, dependent on the localization of mast cells in different organs and the local and systemic effects of ...
Jack Longley +2 more
openaire +3 more sources
Tetraspanins in Mast Cells [PDF]
Frontiers in Immunology, 2012 Mast cells (MC) are key mediators of the immune system, most prominently known for their role in eliciting harmful allergic reactions. Mast cell mediator release (e.g. by degranulation) is triggered by FcεRI recognition of antigen - IgE complexes. Until today no therapeutic targeting of this and other mast cell activation pathways is established. Among
Wolfgang Kempf +4 more
openaire +4 more sources
Urinary and faecal N-methylhistamine concentrations do not serve as markers for mast cell activation or clinical disease activity in dogs with chronic enteropathies [PDF]
, 2014 This study sought to correlate faecal and urinary N-methylhistamine (NMH) concentrations with resting versus degranulated duodenal mast cell numbers in dogs with chronic enteropathies (CE), and investigate correlations between intestinal mast cell ...
Allenspach, K +5 more
core +3 more sources