Results 21 to 30 of about 170,722 (268)
Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective [PDF]
International Neurourology Journal, 2015 Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders.
Tae Young Jang, Young Hyo Kim
doaj +1 more source
Mast Cell Activation Disorders
Medicina, 2021 Background and Objectives: Mast cell disorders comprise a wide spectrum of syndromes caused by mast cells’ degranulation with acute or chronic clinical manifestations.
Arianna Giannetti +4 more
doaj +1 more source
Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells
Cells, 2022 Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed.
Piper A. Robida +15 more
doaj +1 more source
Mediators of Inflammation, 2016 Mast cells are primary effector cells of allergy, and recruitment of mast cells in involved tissue is one of the key events in allergic inflammation. Tryptase is the most abundant secretory product of mast cells, but little is known of its influence on ...
Xin Liu +8 more
doaj +1 more source
Rat embryonic mast cells originate in the AGM. [PDF]
PLoS ONE, 2013 Mast cells originate from pluripotent hematopoietic stem cells. Two mast cell specific antibodies, mAbsAA4 and BGD6, have previously been used to identify and study committed mast cell precursors (MCcps) in the bone marrow of adult mice and rats. However,
Michel Farchi Guiraldelli +7 more
doaj +1 more source
Mast Cells and Their Progenitors in Allergic Asthma
Frontiers in Immunology, 2019 Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
Erika Méndez-Enríquez, Jenny Hallgren
doaj +1 more source
Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder.
Saranya Ramsridhar, Malathi Narasimhan
doaj +1 more source
Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection
Frontiers in Immunology, 2018 Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar +3 more
doaj +1 more source
Cellular Energetics of Mast Cell Development and Activation
Cells, 2021 Mast cells are essential first responder granulocytes in the innate immune system that are well known for their role in type 1 immune hypersensitivity reactions.
Ryan P. Mendoza +2 more
doaj +1 more source
PLoS ONE, 2019 BackgroundPrevious studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell ...
Sribava Sharma +8 more
doaj +1 more source