Results 31 to 40 of about 99 (98)
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai +4 more
wiley +1 more source
Detergent/surfactant retention during ultrafiltration in the formulation of biotherapeutics
Biotechnology Progress, EarlyView.Abstract Surfactants like polysorbate (Tween®) are commonly used as excipients in the production of monoclonal antibodies and other recombinant proteins. The retention behavior of these excipients in the final ultrafiltration step can be difficult to predict due to the presence of both monomers and micelles.
Liang‐Kai Chu +4 more
wiley +1 more source
Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential
ChemBioEng Reviews, EarlyView.This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona +2 more
wiley +1 more source
From Allergy to Angina: A Unique Presentation of Kounis Syndrome
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Kounis syndrome (KS) is a rare condition characterized by acute coronary syndrome (ACS) triggered by an allergic reaction. This report presents a case of high‐risk ACS associated with a food allergy. A 53‐year‐old male with no prior medical history presented to the emergency department with itching, facial swelling, chest tightness, shortness ...
Momen Ali +3 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito +9 more
wiley +1 more source
Biomarkers of lung congestion and injury in acute heart failure
ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi +9 more
wiley +1 more source
ELECTROPHORESIS, EarlyView.Abstract Heparan sulphates (HSs), a specific class of glycosaminoglycans (GAGs), are important participants of cellular signalling. Analytical characterization of GAGs requires a complex sample preparation workflow. Although a detailed stability and recovery study is available for the chondroitin sulphate GAG class, the literature concerning HS is ...
Domonkos Pál +2 more
wiley +1 more source
Friction Characterization and Mitigation in Large‐Scale 6DOF Multi‐Axial Hybrid Simulation
Earthquake Engineering &Structural Dynamics, EarlyView.ABSTRACT In the last few decades, hybrid simulation has become widely used for understanding the response of structural components and systems under extreme loading conditions. Large‐scale, three‐dimensional (3D), multi‐axial testing facilities with six degrees of freedom (6DOF) are versatile testing systems that can be used for testing a variety of ...
Pedram Mortazavi +7 more
wiley +1 more source
Characterisation of Hedge Burning in the Context of Wildland Urban Interface (WUI) Fire Prevention
Fire and Materials, EarlyView.ABSTRACT With global warming, the wildfire season tends to get longer, causing fatalities and devastating damage to human property. Although many countries have implemented fire risk prevention measures, particularly in Wildland Urban Interfaces (WUI), this finding shows that there are weaknesses in the prevention measures. This is mainly due to a lack
Virginie Tihay‐Felicelli +8 more
wiley +1 more source