Results 41 to 50 of about 10,829,007 (362)

Rat embryonic mast cells originate in the AGM. [PDF]

PLoS ONE, 2013
Mast cells originate from pluripotent hematopoietic stem cells. Two mast cell specific antibodies, mAbsAA4 and BGD6, have previously been used to identify and study committed mast cell precursors (MCcps) in the bone marrow of adult mice and rats. However,
Michel Farchi Guiraldelli, Carolina Nunes França, Devandir Antonio de Souza, Elaine Zayas Marcelino da Silva, Vanina Danuza Toso, Celiane Cardoso Carvalho, Maria Célia Jamur, Constance Oliver   +7 more
doaj   +1 more source

Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells

Cells, 2022
Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed.
Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O’Sullivan   +15 more
doaj   +1 more source

Mast Cells and Their Progenitors in Allergic Asthma

Frontiers in Immunology, 2019
Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
Erika Méndez-Enríquez, Jenny Hallgren
doaj   +1 more source

Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective [PDF]

International Neurourology Journal, 2015
Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders.
Tae Young Jang, Young Hyo Kim
doaj   +1 more source

Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions

Nature, 2014
Mast cells are primary effectors in allergic reactions, and may have important roles in disease by secreting histamine and various inflammatory and immunomodulatory substances. Although they are classically activated by immunoglobulin (Ig)E antibodies, a
Benjamin D. McNeil, P. Pundir, S. Meeker, Liang Han, B. Undem, M. Kulka, Xinzhong Dong   +6 more
semanticscholar   +1 more source

Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder.
Saranya Ramsridhar, Malathi Narasimhan
doaj   +1 more source

Mast Cell Proteoglycans [PDF]

Journal of Histochemistry & Cytochemistry, 2012
Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease. A hallmark morphological feature of mast cells is their large content of cytoplasmic secretory granules, filled with numerous secretory ...
Elin, Rönnberg, Fabio R, Melo, Gunnar, Pejler   +2 more
openaire   +2 more sources

Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators.
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD   +6 more
doaj   +1 more source

Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response.

PLoS ONE, 2019
BackgroundPrevious studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell ...
Sribava Sharma, Sunil Tomar, Mayuri Dharne, Varsha Ganesan, Andrew Smith, Yanfen Yang, Lisa Waggoner, Yui-Hsi Wang, Simon P Hogan   +8 more
doaj   +1 more source

Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection

Frontiers in Immunology, 2018
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren   +3 more
doaj   +1 more source