Results 41 to 50 of about 99 (98)

Microglial IKKβ Alters Central and Peripheral Immune Activity at Distinct Time Points After Spinal Cord Injury

Glia, EarlyView.
Microglial NF‐κB signaling increases M1‐like spinal microglia over time after spinal cord injury. Microglial NF‐κB signaling broadly affects gene expression in spinal cord. Microglial NF‐κB signaling modulates splenocytes acutely after spinal cord injury.
Micaela L. O'Reilly, Mariah J. Wulf, Theresa M. Connors, Ying Jin, Frank Bearoff, Julien Bouyer, Sandhya Kortagere, John R. Bethea, Veronica J. Tom   +8 more
wiley   +1 more source

Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency

Head &Neck, EarlyView.
ABSTRACT Background GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.
Brejjette Aljabi, James A. Stewart, Kirk Withrow, Carissa M. Thomas   +3 more
wiley   +1 more source

Identification of crucial genes for polycystic ovary syndrome and atherosclerosis through comprehensive bioinformatics analysis and machine learning

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To identify potential biomarkers in patients with polycystic ovary syndrome (PCOS) and atherosclerosis, and to explore the common pathologic mechanisms between these two diseases in response to the increased risk of cardiovascular diseases in patients with PCOS.
Lirong Wang, Yanli Zhang, Fan Ji, Zhenmin Si, Chengdong Liu, Xiaoke Wu, Chichiu Wang, Hui Chang   +7 more
wiley   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

Engineered strategies for the allergic disease therapy

Interdisciplinary Medicine, EarlyView.
Allergic diseases exist widely across the globe and now there are very limited therapeutics for the treatment of these diseases. In this review, we summarize the recent advances in engineering strategies including nanoemulsion and hydrogel to improve the therapeutic efficacy of allergen‐specific immunotherapy with decreased side effects and long‐term ...
Yun Tian, Xin Wu, Xiaoqi Sun, Lei Rong, Kai Han   +4 more
wiley   +1 more source

Illuminating Immunity: A Systematic Review of Immune Cell Autofluorescence

Journal of Biophotonics, EarlyView.
ABSTRACT Immunophenotyping provides valuable prognostic and diagnostic information, but is technically complex and expensive. The assessment of autofluorescence is label‐free and provides complex information on cell identity. However, research on its application to immunophenotyping has been heterogenous.
Aline Knab, Caroline Giardina, Shane T. Grey, Ewa M. Goldys, Jared M. Campbell   +4 more
wiley   +1 more source

Up Close and Powerful: Leaders' Personal Sense of Power and Psychological Closeness to Their Team as Antecedents of Leader Humility, Subordinate Job Engagement and Trust

Journal of Organizational Behavior, EarlyView.
ABSTRACT Research on leader humility clearly attests to its positive consequences for followers' work‐related outcomes, yet we have only limited knowledge about the antecedents that facilitate leaders expressing humility. Drawing from theoretical works on leadership and power, we posit that leaders' personal sense of power and their psychological ...
Patrick Liborius, Christian Kiewitz, Anna Faber   +2 more
wiley   +1 more source

Malignant Pleural Effusion: Palliative Managements and Indication for Pleurodesis Based on Survival Scores

Journal of Surgical Oncology, EarlyView.
ABSTRACT Neoplastic pleural effusion is one in which malignant neoplastic cells are detected in the pleural fluid or in the parietal pleura. When secondary, it confirms disseminated neoplastic disease and suggests a reduced life expectancy and low quality of life.
Erlon de Avila Carvalho, Rachid Eduardo Noleto da Nobrega Oliveira, José Henrique Agner Ribeiro, Jefferson Luís Gross, Cezar Augusto Vendas Galhardo, Heládio Feitosa e Castro Neto, Giovana dos Santos, Reitan Ribeiro, Alexandre Ferreira Oliveira, Rodrigo Nascimento Pinheiro   +9 more
wiley   +1 more source

Ixekizumab Type I Allergy in a Patient With Psoriasis

JEADV Clinical Practice, EarlyView.
ABSTRACT A 52‐year‐old Caucasian woman was referred for an allergy workup of suspected type I allergy to the interleukin (IL)‐17A inhibitor ixekizumab. Five months after ixekizumab initiation, she suddenly developed intense pruritus and three small wheals at the injection site approximately 30 min after injection, lasting up to 3 days.
Carina Borst, Constanze Jonak, Christine Bangert   +2 more
wiley   +1 more source

Oral Administration of Trichosanthes Kirilowii Fruit Extract Ameliorates Airway Inflammation and Suppresses Th2 Cell Activities in Ovalbumin‐Sensitized Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Trichosanthes kirilowii is a plant used in traditional Chinese medicine. Its fruits, seeds, and roots can all be used medicinally. The fruit of T. kirilowii has a moistening effect on the lung for arresting cough. However, there is no scientific research to prove that the fruit of T. kirilowii can improve asthma. Herein, we evaluated whether T.
Ting‐Chi Lin, Wen‐Chung Huang, Chwan‐Fwu Lin, Wan‐Ting Chi, Shu‐Chen Cheng, Nai‐Chun Ting, Chian‐Jiun Liou   +6 more
wiley   +1 more source