Results 41 to 50 of about 304,209 (218)

Mast Cells and Their Progenitors in Allergic Asthma

Frontiers in Immunology, 2019
Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
Erika Méndez-Enríquez, Jenny Hallgren
doaj   +1 more source

Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder.
Saranya Ramsridhar, Malathi Narasimhan
doaj   +1 more source

Human Skin/SCID Mouse Chimeras as an In Vivo Model for Human Cutaneous Mast Cell Hyperplasia [PDF]

, 1997
Human skin xenografted to mice with severe combined immunodeficiency syndrome (SCID) was evaluated to determine the integrity and fate of human dermal mast cells.
Melpo Christofidou-Solomidou, B. Jack Longley, Diana Whitaker-Menezes, Steven M. Albelda, George F. Murphy, Bosma, Caufield, Chomszynski, Christofidou-Solomidou, Christofidou-Solomidou, Costa, Dvorak, Galli, Gilliam, Grichnick, Gruber, Inemura, Juhasz, Juhasz, Juhasz, Kaminer, Karnovsky, Kessler, Lavker, Longley, Longley, Longley, Longley, Matsumura, Meininger, Mekori, Mirowski, Murphy, Petzelbauer, Schechter, Tsai, Valent, Walsh, Weidner, Weiss, Whitaker-Menezes, Yan, Yan   +42 more
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Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection

Frontiers in Immunology, 2018
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren   +3 more
doaj   +1 more source

Cellular Energetics of Mast Cell Development and Activation

Cells, 2021
Mast cells are essential first responder granulocytes in the innate immune system that are well known for their role in type 1 immune hypersensitivity reactions.
Ryan P. Mendoza, Dylan H. Fudge, Jared M. Brown   +2 more
doaj   +1 more source

Mast Cell Proteoglycans [PDF]

Journal of Histochemistry & Cytochemistry, 2012
Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease. A hallmark morphological feature of mast cells is their large content of cytoplasmic secretory granules, filled with numerous secretory ...
Elin, Rönnberg, Fabio R, Melo, Gunnar, Pejler   +2 more
openaire   +2 more sources

Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]

, 2010
Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P., Sotlar, K., Valent, P.
core   +1 more source

Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators.
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD   +6 more
doaj   +1 more source

Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response.

PLoS ONE, 2019
BackgroundPrevious studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell ...
Sribava Sharma, Sunil Tomar, Mayuri Dharne, Varsha Ganesan, Andrew Smith, Yanfen Yang, Lisa Waggoner, Yui-Hsi Wang, Simon P Hogan   +8 more
doaj   +1 more source

Comparative analysis of mast cell count in normal oral mucosa and oral pyogenic granuloma [PDF]

, 2011
Introduction: Mast cells are large granular cells that arise from a multipotent CD 34+ precursor in the bone marrow normally distributed throughout connective tissues.
Dahiya, Parveen, Kamal, Reet, Palaskar, Sangeeta, Shetty, V.P.   +3 more
core   +1 more source