Results 41 to 50 of about 337,935 (358)

Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective [PDF]

International Neurourology Journal, 2015
Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders.
Tae Young Jang, Young Hyo Kim
doaj   +1 more source

Comparative analysis of mast cell count in normal oral mucosa and oral pyogenic granuloma [PDF]

, 2011
Introduction: Mast cells are large granular cells that arise from a multipotent CD 34+ precursor in the bone marrow normally distributed throughout connective tissues.
Dahiya, Parveen, Kamal, Reet, Palaskar, Sangeeta, Shetty, V.P.   +3 more
core   +1 more source

Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection

Frontiers in Immunology, 2018
Mast cells release disease-causing mediators and accumulate in the lung of asthmatics. The most common cause of exacerbations of asthma is respiratory virus infections such as influenza. Recently, we demonstrated that influenza infection in mice triggers
Behdad Zarnegar, Annika Westin, Syrmoula Evangelidou, Jenny Hallgren   +3 more
doaj   +1 more source

Cellular Energetics of Mast Cell Development and Activation

Cells, 2021
Mast cells are essential first responder granulocytes in the innate immune system that are well known for their role in type 1 immune hypersensitivity reactions.
Ryan P. Mendoza, Dylan H. Fudge, Jared M. Brown   +2 more
doaj   +1 more source

Interactions between mast cells and smooth muscle in asthma models [PDF]

, 2014
Allergic asthma is the major phenotype of asthma and is characterized by specific responses to allergens as well as airway hyperresponsiveness (AHR), inflammation and remodelling.
Sjöberg, Lisa
core   +1 more source

Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell–derived mediators.
Yuzhi Yin, MD, PhD, Jenny Min Li, PhD, Dean D. Metcalfe, MD, Ana Olivera, PhD, Pamela A. Frischmeyer-Guerrerio, MD, PhD, Melody C. Carter, MD, Hirsh Komarow, MD   +6 more
doaj   +1 more source

Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response.

PLoS ONE, 2019
BackgroundPrevious studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell ...
Sribava Sharma, Sunil Tomar, Mayuri Dharne, Varsha Ganesan, Andrew Smith, Yanfen Yang, Lisa Waggoner, Yui-Hsi Wang, Simon P Hogan   +8 more
doaj   +1 more source

Tetraspanins in Mast Cells [PDF]

Frontiers in Immunology, 2012
Mast cells (MC) are key mediators of the immune system, most prominently known for their role in eliciting harmful allergic reactions. Mast cell mediator release (e.g. by degranulation) is triggered by FcεRI recognition of antigen - IgE complexes. Until today no therapeutic targeting of this and other mast cell activation pathways is established. Among
Köberle, Martin, Kaesler, Susanne, Kempf, Wolfgang, Wölbing, Florian, Biedermann, Tilo   +4 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mast cell responses to danger signals [PDF]

, 2012
Detecting and responding to danger is a paramount function of the immune system. Compounds heralding danger can be divided into two groups: exogenous and endogenous danger signals.
Enoksson, Mattias
core   +1 more source