Results 61 to 70 of about 337,935 (358)

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells [PDF]

, 2015
Background: Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking ...
A Ito, A Trautmann, CE Brightling, CE Brightling, CE Brightling, CT Mierke, D Sanmugalingam, D Smrz, EA Kabat, EP Moiseeva, F Hollins, J Sambrook, JM Blechman, KC Gough, KL Knight, M Popkov, MY Oh, NG Carroll, P Bradding, P Bradding, PO Girodet, SA Kuhne, SM Duffy, W Yang, Y Koma, Y Li, Y Shimizu   +26 more
core   +2 more sources

Activation of the receptor KIT induces the secretion of exosome‐like small extracellular vesicles

Journal of Extracellular Biology
The receptor tyrosine kinase (RTK) KIT and its ligand stem cell factor (SCF) are essential for human mast cell (huMC) survival and proliferation. HuMCs expressing oncogenic KIT variants secrete large numbers of extracellular vesicles (EVs).
Annika Pfeiffer, Geethani Bandara, Jennifer D. Petersen, Guido H. Falduto, Joshua Zimmerberg, Dean D. Metcalfe, Ana Olivera   +6 more
doaj   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Global microRNA expression is essential for murine mast cell development in vivo [PDF]

, 2014
MicroRNAs (miRNAs) are small, noncoding RNAs that have been shown to play a critical role in normal physiology and disease, such as hematopoietic development and cancer. However, their role in mast-cell function and development is poorly understood.
Brandal, Stephanie, Kapur, Reuben, Oh, Sun Young, Takemoto, Clifford, Zhu, Zhou   +4 more
core   +1 more source

A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers

OncoImmunology, 2017
To date, the exact impact of mast cells in tumor microenvironment is still controversial because of inconsistency in observations regarding the relationship between mast cell infiltrates and cancer development and prognosis. The discrepancies in previous
Eun-A Ko, Kenton M. Sanders, Tong Zhou
doaj   +1 more source

Mast cell tissue heterogeneity and specificity of immune cell recruitment

Frontiers in Immunology, 2022
Mast cells occupy a unique niche within tissues as long lived perpetrators of IgE mediated hypersensitivity and anaphylaxis, as well as other immune responses.
Peter W. West, Silvia Bulfone-Paus
doaj   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

Mucosal Mast Cells Response in the Jejunum of Ascaridia Galli-Infected Laying Hens [PDF]

, 2013
Intestinal defense mechanism against helminthes parasitic nematode to be associated with mucosal mast cells reaction. The aim of this research was to examine the effect of infection by Ascaridia galli parasite to trigger mucosal defense based on mucosal ...
Balqis, U. (U), Darmawi, D. (Darmawi), Frengki, F. (Frengki), Hambal, M. (M), Priosoeryanto, B. P. (B)   +4 more
core  

SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis [PDF]

, 2014
SHP2 protein-tyrosine phosphatase (encoded by Ptpn11) positively regulates KIT (CD117) signaling in mast cells and is required for mast cell survival and homeostasis in mice.
Craig, Andrew W.B., Everingham, Stephanie, Kapur, Reuben, Ramdas, Baskar, Sharma, Namit   +4 more
core   +2 more sources