Results 61 to 70 of about 10,756,993 (383)
Cellular Energetics of Mast Cell Development and Activation
Cells, 2021 Mast cells are essential first responder granulocytes in the innate immune system that are well known for their role in type 1 immune hypersensitivity reactions.
Ryan P. Mendoza +2 more
doaj +1 more source
Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions
Nature, 2014 Mast cells are primary effectors in allergic reactions, and may have important roles in disease by secreting histamine and various inflammatory and immunomodulatory substances. Although they are classically activated by immunoglobulin (Ig)E antibodies, a
Benjamin D. McNeil +6 more
semanticscholar +1 more source
, 2016 Mast cell tumor is one of the major cutaneous tumors in dogs. Though the etiology of MCTs is not completely understood, it becomes clear that approximately 10–20% MCTs express mutant KIT receptors with ligand‐independent phosphorylation.
Y. Amagai, A. Tanaka
semanticscholar +1 more source
Allergy. European Journal of Allergy and Clinical Immunology, 2015 Mast cell localization within the airway smooth muscle (ASM)‐bundle plays an important role in the development of airway hyper‐responsiveness (AHR). Genomewide association studies implicate the ‘alarmin’ IL‐33 in asthma, but its role in mast cell–ASM ...
D. Kaur +13 more
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012 Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of
Danae A. Delivanis +10 more
openaire +3 more sources
PLoS ONE, 2019 BackgroundPrevious studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell ...
Sribava Sharma +8 more
doaj +1 more source
Rat embryonic mast cells originate in the AGM. [PDF]
PLoS ONE, 2013 Mast cells originate from pluripotent hematopoietic stem cells. Two mast cell specific antibodies, mAbsAA4 and BGD6, have previously been used to identify and study committed mast cell precursors (MCcps) in the bone marrow of adult mice and rats. However,
Michel Farchi Guiraldelli +7 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundImmunohistochemical analysis of granule-associated proteases has revealed that human lung mast cells constitute a heterogeneous population of cells, with distinct subpopulations identified.
Elin Rönnberg +18 more
doaj +1 more source
Mast Cell-Mediated Mechanisms of Nociception
International Journal of Molecular Sciences, 2015 Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense.
A. Aich, L. Afrin, K. Gupta
semanticscholar +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source