Results 71 to 80 of about 10,756,993 (383)

Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective [PDF]

International Neurourology Journal, 2015
Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders.
Tae Young Jang, Young Hyo Kim
doaj   +1 more source

The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis

BioMed Research International, 2015
An association between mast cells and tumor angiogenesis is known to exist, but the exact role that mast cells play in this process is still unclear. It is thought that the mediators released by mast cells are important in neovascularization. However, it
D. A. de Souza Júnior, Ana Carolina Santana, E. Z. M. da Silva, C. Oliver, M. Jamur   +4 more
semanticscholar   +1 more source

Stains Induce Apoptosis and Autophagy in Primary and Transformed Mast Cells [PDF]

, 2016
Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for ...
Paez, Patrick A
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome

International Journal of Infectious Diseases, 2020
Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2.
Lawrence B. Afrin, Leonard B. Weinstock, Gerhard J. Molderings   +2 more
doaj  

Mast cell tissue heterogeneity and specificity of immune cell recruitment

Frontiers in Immunology, 2022
Mast cells occupy a unique niche within tissues as long lived perpetrators of IgE mediated hypersensitivity and anaphylaxis, as well as other immune responses.
Peter W. West, Silvia Bulfone-Paus
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Mast Cell Function

Journal of Histochemistry and Cytochemistry, 2014
Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as effectors of allergy. It has been only in the past two decades that mast cells have gained recognition for their involvement in other physiological and pathological ...
E. Z. M. da Silva, M. Jamur, C. Oliver
semanticscholar   +1 more source

Human Skin/SCID Mouse Chimeras as an In Vivo Model for Human Cutaneous Mast Cell Hyperplasia [PDF]

, 1997
Human skin xenografted to mice with severe combined immunodeficiency syndrome (SCID) was evaluated to determine the integrity and fate of human dermal mast cells.
Melpo Christofidou-Solomidou, B. Jack Longley, Diana Whitaker-Menezes, Steven M. Albelda, George F. Murphy, Bosma, Caufield, Chomszynski, Christofidou-Solomidou, Christofidou-Solomidou, Costa, Dvorak, Galli, Gilliam, Grichnick, Gruber, Inemura, Juhasz, Juhasz, Juhasz, Kaminer, Karnovsky, Kessler, Lavker, Longley, Longley, Longley, Longley, Matsumura, Meininger, Mekori, Mirowski, Murphy, Petzelbauer, Schechter, Tsai, Valent, Walsh, Weidner, Weiss, Whitaker-Menezes, Yan, Yan   +42 more
core   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source