Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel. [PDF]
, 2009 BACKGROUND: Advanced age is associated with a reduction in clinical visceral pain perception. However, the underlying mechanisms remain largely unknown.
Firth +40 more
core +1 more source
CD117 immunoexpression in canine mast cell tumours: correlations with pathological variables and proliferation markers [PDF]
, 2007 Background Cutaneous mast cell tumours are one of the most common neoplasms in dogs and show a highly variable biologic behaviour. Several prognosis tools have been proposed for canine mast cell tumours, including histological grading and cell ...
Pires Maria A +5 more
core +2 more sources
Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9 [PDF]
, 2010 As genetically engineered mutant mice deficient in single genes are usually generated on a C57BL/6 background, to study mast cell trafficking in mutant mice, we initially investigated whether mast cells accumulated in bronchi in C57BL/6 mice challenged ...
Suzan Pae +5 more
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Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. [PDF]
, 2017 Inappropriate activation of mast cells via the FcεRI receptor leads to the release of inflammatory mediators and symptoms of allergic disease. Calcium influx is a critical regulator of mast cell signaling and is required for exocytosis of preformed ...
Alfonso +68 more
core +1 more source
Mast cell-derived mediators promote murine neutrophil effector functions [PDF]
, 2017 Mast cells are able to trigger life-saving immune responses in murine models for acute inflammation. In such settings, several lines of evidence indicate that the rapid and protective recruitment of neutrophils initiated by the release of mast cell ...
Becker, Marc +15 more
core
Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection [PDF]
, 2008 Although the innate immune function of mast cells in the acute phase of parasitic and bacterial infections is well established, their participation in chronic immune responses to indolent infection remains incompletely understood.
Friend, Daniel S. +6 more
core +1 more source
Mast cell carboxypeptidase A, a secretory granule component [PDF]
, 2005 Mast cells are highly granulated cells of the immune system that upon stimulation release a number of inflammatory mediators including heparin and/or chondroitin sulphate (CS) proteoglycan (PG) and various heparin-binding proteases such as tryptase ...
Henningsson, Frida
core
Mast cells produce a unique chondroitin sulfate epitope [PDF]
, 2016 The granules of mast cells contain a myriad of mediators that are stored and protected by the sulfated glycosaminoglycan (GAG) chains that decorate proteoglycans.
Caterson, Bruce +4 more
core +1 more source
Metformin: A potential adjunct for treatment of systemic mastocytosis
Journal of Allergy and Clinical Immunology: GlobalBackground: Systemic mastocytosis (SM) is a clonal disorder of mast cells in which the KIT Asp816Val mutation can be detected not only in mature mast cells but also in the hematopoietic stem cell and in non–mast cell lineages.
Joseph H. Butterfield, MD +1 more
doaj +1 more source