Results 81 to 90 of about 170,722 (268)

Spatial Transcriptional Dynamics of CD74⁺ B Cells in Tertiary Lymphoid Structures Drive Immune Evolution in Penile Squamous Cell Carcinoma

Advanced Science, EarlyView.
In penile squamous cell carcinoma, a higher tertiary lymphoid structure score is associated with improved survival. This is mediated by CD74⁺ B cells, which exhibit early developmental plasticity and the ability to differentiate into plasma cells. Functioning as a molecular switch, these cells activate naive T cells via HLA‐DRA–CD4 interaction, thereby
Ting Xue, Chuangzhong Deng, Jingya Liu, Ru Yan, Jing Li, Xiheng Hu, Xueying Li, Xiao Xiao, Jietian Jin, Hongzhen Tang, Desi Chen, Zihan Zuo, Yujie Liang, Dongbin Wang, Bonan Chen, Hui Han, Zaishang Li   +16 more
wiley   +1 more source

Mast cell synapses and exosomes: membrane contacts for information exchange

Frontiers in Immunology, 2012
In addition to their central role in allergy, mast cells are involved in a wide variety of cellular interactions during homeostasis and disease.
Amanda eCarroll-Portillo, Zurab eSurviladze, Alessandra eCambi, Diane S. Lidke, Bridget S eWilson   +4 more
doaj   +1 more source

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

Advanced Science, EarlyView.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang, Guangcong Shen, Guanpeng Xie, Zekun Li, Xiaoqing Ma, Mengyu Li, Ziyun Liu, Yadi Wang, Zongjing Lv, Qingxiao Fang, Huihui Sun, Ningning Zhao, Chao Yang, Tianxing Zhou, Yongjie Xie, Jun Yu, Jihui Hao   +16 more
wiley   +1 more source

Epigenetic Regulation via Altered Histone Acetylation Results in Suppression of Mast Cell Function and Mast Cell-Mediated Food Allergic Responses

Frontiers in Immunology, 2018
Mast cells are highly versatile cells that perform a variety of functions depending on the immune trigger, context of activation, and cytokine stimulus.
Dylan Krajewski, Edwin Kaczenski, Jeffrey Rovatti, Stephanie Polukort, Chelsea Thompson, Catherine Dollard, Catherine Dollard, Jennifer Ser-Dolansky, Sallie S. Schneider, Shannon R. M. Kinney, Clinton B. Mathias   +10 more
doaj   +1 more source

Depletion of Preβ ₁ LpA1 and LpA4 Particles by Mast Cell Chymase Reduces Cholesterol Efflux From Macrophage Foam Cells Induced by Plasma [PDF]

, 1999
Miriam Lee, Arnold von Eckardstein, Leena Lindstedt, Gerd Assmann, Petri T Kovanen   +4 more
openalex   +1 more source

Interfacial Coordination‐Engineered Emulgel Modulates the Osteo‐Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway‐Induced Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of HIPPE‐QU‐mediated periodontal regeneration. a) Fabrication process and microstructure of HIPPE‐QU. b) Antimicrobial and immunomodulatory HIPPE‐QU hydrogel for periodontal regeneration. HIPPE‐QU hydrogel co‐delivers HA‐Cu, GNPs, and QU, providing antimicrobial effects and reprogramming the immune microenvironment to promote ...
Hui Zhang, Xiao Huang, Rui Chen, Weimin Lin, Linke Li, Xi Peng, Xinxi Yang, Xingyu Chen, Tailin Guo, Jie Weng, Jianshu Li, Quan Yuan, Huan Tan, Mengyuan Wang   +13 more
wiley   +1 more source

SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo

Scientific Reports, 2017
Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation.
Hanna Pettersson, Behdad Zarnegar, Annika Westin, Viktor Persson, Christiane Peuckert, Jörgen Jonsson, Jenny Hallgren, Klas Kullander   +7 more
doaj   +1 more source

IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors [PDF]

, 2021
Leonardo Cristinziano, Remo Poto, Gjada Criscuolo, Anne Lise Ferrara, Maria Rosaria Galdiero, Luca Modestino, Stefania Loffredo, Amato de Paulis, Gianni Marone, Giuseppe Spadaro, Gilda Varricchi   +10 more
openalex   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, EarlyView.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source