Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis [PDF]
Nature CommunicationsHuman cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM).
Do Hyeon Gim +6 more
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A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and niches [PDF]
Communications BiologyInteractions among tumor, immune, and vascular niches play major roles in glioblastoma (GBM) malignancy and treatment responses. The composition and heterogeneity of extracellular core matrix proteins (CMPs) that mediate such interactions are not well ...
Monika Vishnoi +13 more
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Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types [PDF]
Matrix Biology Plus, 2019 The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome.
Valerio Izzi +6 more
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MatriCom, a single-cell RNA-sequencing data mining tool to infer cell-extracellular matrix interactions. [PDF]
J Cell SciThe ECM is a complex meshwork of proteins forming the framework of all multicellular organisms. Protein interactions are critical to building and remodeling the ECM meshwork, while interactions between ECM proteins and receptors are essential to initiate
Lamba R +4 more
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Generation of decellularized human brain tissue for investigating cell-matrix interactions: a proof-of-concept study [PDF]
Frontiers in Bioengineering and BiotechnologyThe brain extracellular matrix (ECM) regulates myelin repair and regeneration following a demyelinating event by interacting with neuronal progenitors and immune cells. Therefore, generation and characterization of decellularized human brain tissue (DHBT)
Roemel Jeusep Bueno +15 more
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Analysis of matrisome expression patterns in murine and human dorsal root ganglia
Frontiers in Molecular Neuroscience, 2023 The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome.
Robin Vroman +13 more
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Inflammation-related citrullination of matrisome proteins in human cancer
Frontiers in Oncology, 2022 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu +3 more
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The Matrisome Genes From Hepatitis B–Related Hepatocellular Carcinoma Unveiled
Hepatology Communications, 2021 Chronic hepatitis B virus (HBV) infection changes the composition of the extracellular matrix (ECM) and enables the onset and progression of hepatocellular carcinoma (HCC).
Wei Chen +8 more
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Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices
Frontiers in Bioengineering and Biotechnology, 2023 The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop.
Wei Chen +11 more
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Extracellular matrix gene expression signatures as cell type and cell state identifiers
Matrix Biology Plus, 2021 Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher +3 more
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