Results 1 to 10 of about 5,938 (234)

Atlas of mildly and highly insoluble matrisome driving liver fibrosis [PDF]

Frontiers in Pharmacology
The excessive deposition and cross-linking of core matrisome components typically result in abnormal remodeling of the extracellular matrix (ECM), leading to increased liver stiffness and worsening liver fibrosis.
Wen Zhang, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Ning Zhang, Wenyue Wu, Wenyue Wu, Wenyue Wu, Hong Li, Hong Li, Hong Li, Hong Li, Hong You, Hong You, Hong You, Wei Chen, Wei Chen, Wei Chen, Wei Chen, Wei Chen   +20 more
doaj   +3 more sources

Analysis of cancer cell line and tissue RNA sequencing data reveals an essential and dark matrisome [PDF]

Matrix Biology Plus
Extracellular matrix remodeling is a hallmark of tissue development, homeostasis, and disease. The processes that mediate remodeling, and the consequences of such, are the topic of extensive focus in biomedical research.
Joshua A. Rich, Yu Fan, Qingrong Chen, Daoud Meerzaman, William G. Stetler-Stevenson, David Peeney   +5 more
doaj   +3 more sources

Analysis of matrisome expression patterns in murine and human dorsal root ganglia

Frontiers in Molecular Neuroscience, 2023
The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome.
Robin Vroman, Rahel S. Hunter, Matthew J. Wood, Olivia C. Davis, Zoë Malfait, Dale S. George, Dongjun Ren, Diana Tavares-Ferreira, Theodore J. Price, Richard J. Miller, Anne-Marie Malfait, Fransiska Malfait, Rachel E. Miller, Delfien Syx   +13 more
doaj   +2 more sources

Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo

Biomolecules
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin.
Yan Yan, Hehui Quan, Chunfang Guo, Zhaoping Qin, Taihao Quan   +4 more
doaj   +2 more sources

Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types [PDF]

Matrix Biology Plus, 2019
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome.
Valerio Izzi, Juho Lakkala, Raman Devarajan, Anni Kääriäinen, Jarkko Koivunen, Ritva Heljasvaara, Taina Pihlajaniemi   +6 more
doaj   +3 more sources

Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis [PDF]

Nature Communications
Human cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM).
Do Hyeon Gim, Muhammad Z. K. Assir, Olivia Soper, Paul A. Fowler, Michael D. Morgan, Daniel A. Berg, Eunchai Kang   +6 more
doaj   +2 more sources

The matrisome landscape controlling in vivo germ cell fates

Nature Communications
The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development.
Aqilah Amran, Lara Pigatto, Johanna Farley, Rasoul Godini, Roger Pocock, Sandeep Gopal   +5 more
doaj   +2 more sources

Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices

Frontiers in Bioengineering and Biotechnology, 2023
The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop.
Wei Chen, Wei Chen, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Shuyan Chen, Shuyan Chen, Tao Huang, Tao Huang, Hong You, Hong You   +11 more
doaj   +2 more sources

Heterogeneity of ovarian matrisome hydrogels elucidates factors that may influence follicle growth in vitro. [PDF]

Reproduction
This work describes a valuable and reproducible method for generating optically clear bovine ovary-derived hydrogels that support in vitro murine follicle growth. These techniques are the foundation in which follicle growth dynamics and matrisome protein
McDowell HB, Henning NF, Laronda MM.
europepmc   +2 more sources

MatriCom, a single-cell RNA-sequencing data mining tool to infer cell-extracellular matrix interactions. [PDF]

J Cell Sci
The ECM is a complex meshwork of proteins forming the framework of all multicellular organisms. Protein interactions are critical to building and remodeling the ECM meshwork, while interactions between ECM proteins and receptors are essential to initiate
Lamba R, Paguntalan AM, Petrov PB, Naba A, Izzi V.   +4 more
europepmc   +3 more sources