Results 1 to 10 of about 5,505 (195)

Novel prognostic matrisome-related gene signature of head and neck squamous cell carcinoma [PDF]

Frontiers in Cell and Developmental Biology, 2022
Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy of the mucosal epithelium of the oral cavity, pharynx, and larynx.
Chao Huang, Chao Huang, Yun Liang, Yun Liang, Yi Dong, Yi Dong, Li Huang, Anlei Li, Ran Du, Ran Du, Hao Huang, Hao Huang, Hao Huang, Hao Huang   +13 more
doaj   +2 more sources

Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis [PDF]

Nature Communications
Human cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM).
Do Hyeon Gim, Muhammad Z. K. Assir, Olivia Soper, Paul A. Fowler, Michael D. Morgan, Daniel A. Berg, Eunchai Kang   +6 more
doaj   +2 more sources

A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and niches [PDF]

Communications Biology
Interactions among tumor, immune, and vascular niches play major roles in glioblastoma (GBM) malignancy and treatment responses. The composition and heterogeneity of extracellular core matrix proteins (CMPs) that mediate such interactions are not well ...
Monika Vishnoi, Zeynep Dereli, Zheng Yin, Elisabeth K. Kong, Meric Kinali, Kisan Thapa, Ozgun Babur, Kyuson Yun, Nourhan Abdelfattah, Xubin Li, Behnaz Bozorgui, Mary C. Farach-Carson, Robert C. Rostomily, Anil Korkut   +13 more
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Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types [PDF]

Matrix Biology Plus, 2019
The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome.
Valerio Izzi, Juho Lakkala, Raman Devarajan, Anni Kääriäinen, Jarkko Koivunen, Ritva Heljasvaara, Taina Pihlajaniemi   +6 more
doaj   +3 more sources

Molecular dynamics of the matrisome across sea anemone life history [PDF]

eLife
The evolutionary expansion of extracellular matrix (ECM) molecules has been crucial for the establishment of cell adhesion and the transition from unicellular to multicellular life.
Bruno Gideon Bergheim, Alison G Cole, Mandy Rettel, Frank Stein, Stefan Redl, Michael W Hess, Aissam Ikmi, Suat Özbek   +7 more
doaj   +2 more sources

MatriCom, a single-cell RNA-sequencing data mining tool to infer cell-extracellular matrix interactions. [PDF]

J Cell Sci
The ECM is a complex meshwork of proteins forming the framework of all multicellular organisms. Protein interactions are critical to building and remodeling the ECM meshwork, while interactions between ECM proteins and receptors are essential to initiate
Lamba R, Paguntalan AM, Petrov PB, Naba A, Izzi V.   +4 more
europepmc   +3 more sources

Generation of decellularized human brain tissue for investigating cell-matrix interactions: a proof-of-concept study [PDF]

Frontiers in Bioengineering and Biotechnology
The brain extracellular matrix (ECM) regulates myelin repair and regeneration following a demyelinating event by interacting with neuronal progenitors and immune cells. Therefore, generation and characterization of decellularized human brain tissue (DHBT)
Roemel Jeusep Bueno, Roemel Jeusep Bueno, Roemel Jeusep Bueno, Camila Fernández-Zapata, Maren Salla, Maren Salla, Maren Salla, Juliana Campo Garcia, Aylin Alacam, Oliver Klein, Chotima Böttcher, Helena Radbruch, Friedemann Paul, Sarah C. Starossom, Rafaela V. Silva, Carmen Infante-Duarte   +15 more
doaj   +2 more sources

Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis [PDF]

eLife
Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease.
Marketa Jirouskova, Karel Harant, Pavel Cejnar, Srikant Ojha, Katerina Korelova, Lenka Sarnova, Eva Sticova, Christoph H Mayr, Herbert B Schiller, Martin Gregor   +9 more
doaj   +2 more sources

Analysis of matrisome expression patterns in murine and human dorsal root ganglia

Frontiers in Molecular Neuroscience, 2023
The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome.
Robin Vroman, Rahel S. Hunter, Matthew J. Wood, Olivia C. Davis, Zoë Malfait, Dale S. George, Dongjun Ren, Diana Tavares-Ferreira, Theodore J. Price, Richard J. Miller, Anne-Marie Malfait, Fransiska Malfait, Rachel E. Miller, Delfien Syx   +13 more
doaj   +1 more source

Inflammation-related citrullination of matrisome proteins in human cancer

Frontiers in Oncology, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu, Ujjwal Suwal, Elina Siljamäki, Jyrki Heino   +3 more
doaj   +1 more source