Impact of Gut Recolonization on Liver Regeneration: Hepatic Matrisome Gene Expression after Partial Hepatectomy in Mice. [PDF]
International Journal of Molecular Sciences, 2023 The hepatic matrisome is involved in the remodeling phase of liver regeneration. As the gut microbiota has been implicated in liver regeneration, we investigated its role in liver regeneration focusing on gene expression of the hepatic matrisome after ...
Amin AR +7 more
core +5 more sources
Matrisome AnalyzeR: A suite of tools to annotate and quantify ECM molecules in big datasets across organisms [PDF]
bioRxiv, 2023 The extracellular matrix (ECM) is a complex meshwork of proteins that forms the scaffold of all tissues in multicellular organisms. It plays critical roles in all aspects of life: from orchestrating cell migration during development, to supporting tissue
Petar B. Petrov +3 more
semanticscholar +2 more sources
Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome [PDF]
bioRxiv, 2022 Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) and plasma from ...
E. Dammer +7 more
semanticscholar +2 more sources
Novel prognostic matrisome-related gene signature of head and neck squamous cell carcinoma [PDF]
Frontiers in Cell and Developmental Biology, 2022 Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy of the mucosal epithelium of the oral cavity, pharynx, and larynx.
Chao Huang +13 more
doaj +2 more sources
Comprehensive Matrisome Profiling of Human Adipose Tissue for Soft Tissue Reconstruction [PDF]
Advances in Biology, 2023 For effective translation of research from tissue engineering and regenerative medicine domains, the cell‐instructive extracellular matrix (ECM) of specific tissues must be accurately realized.
Gretel S. Major +5 more
semanticscholar +2 more sources
Generation of Tailored Extracellular Matrix Hydrogels for the Study of In Vitro Folliculogenesis in Response to Matrisome-Dependent Biochemical Cues [PDF]
BioengineeringWhile ovarian tissue cryopreservation (OTC) is an important fertility preservation option, it has its limitations. Improving OTC and ovarian tissue transplantation (OTT) must include extending the function of reimplanted tissue by reducing the extensive ...
Hannah B McDowell +3 more
semanticscholar +2 more sources
Matrisome gene-based subclassification of patients with liver fibrosis identifies clinical and molecular heterogeneities [PDF]
Hepatology, 2023 Patients with pre-treatment or post-treatment liver fibrosis, or even with identical histological fibrosis stages, can be subclassified into LFMGLow and LFMGHigh based on the microfibrillar-associated protein 4 + activated HSC LFMG signature. LFMGLow and
Wei Chen +15 more
semanticscholar +2 more sources
Challenges and Opportunities Modeling the Dynamic Tumor Matrisome [PDF]
BME Frontiers, 2023 We need novel strategies to target the complexity of cancer and, particularly, of metastatic disease. As an example of this complexity, certain tissues are particularly hospitable environments for metastases, whereas others do not contain fertile ...
Shelly R. Peyton, M. Platt, E. Cukierman
semanticscholar +2 more sources
Matrisome and Immune Pathways Contribute to Extreme Vascular Outcomes in Williams–Beuren Syndrome
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Supravalvar aortic stenosis (SVAS) is a characteristic feature of Williams–Beuren syndrome (WBS). Its severity varies: ~20% of people with Williams–Beuren syndrome have SVAS requiring surgical intervention, whereas ~35% have no appreciable ...
Delong Liu +24 more
doaj +2 more sources
Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis [PDF]
bioRxiv, 2022 Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages which respond to an initial inflammatory insult common in all forms of fibrosis.
Kevin Y. Huang +6 more
semanticscholar +2 more sources