Spatially resolved transcriptomic profiling identifies distinct signatures in parenchymal and vascular microenvironments in Alzheimer's Disease with Cerebral Amyloid Angiopathy. [PDF]
Alzheimers DementAbstract INTRODUCTION Alzheimer's disease (AD) pathology frequently coexists with cerebral amyloid angiopathy (CAA), in which amyloid beta (Aβ) deposits in cerebral blood vessels. Although anti‐Aβ immunotherapies can reduce parenchymal plaques, they often exacerbate vascular pathology.
Chimal-Juárez E +4 more
europepmc +2 more sources
GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer. [PDF]
Adv Sci (Weinh)Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Curvello R +10 more
europepmc +2 more sources
Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers
Matrix Biology Plus, 2022 Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression.
Carson J. Cook +4 more
doaj +1 more source
Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data
Scientific Reports, 2021 The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues,
Tim O. Nieuwenhuis +3 more
doaj +1 more source
Novel prognostic matrisome-related gene signature of head and neck squamous cell carcinoma
Frontiers in Cell and Developmental Biology, 2022 Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy of the mucosal epithelium of the oral cavity, pharynx, and larynx.
Chao Huang +13 more
doaj +1 more source
Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]
, 2016 Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA +26 more
core +5 more sources
The liver matrisome – looking beyond collagensKey points
JHEP Reports, 2020 Summary: The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional communication with surrounding cells to regulate cell and tissue homeostasis.
Gavin E. Arteel, Alexandra Naba
doaj +1 more source
Microgravity Effects on the Matrisome
Cells, 2021 Gravity is fundamental factor determining all processes of development and vital activity on Earth. During evolution, a complex mechanism of response to gravity alterations was formed in multicellular organisms.
Ludmila Buravkova +3 more
doaj +1 more source
BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas [PDF]
, 2016 Bone Morphogenic Protein 2 (BMP2) is a multipurpose cytokine, important in the development of bone and cartilage, and with a role in tumour initiation and progression.
Cassidy, A.P. +3 more
core +3 more sources
Proteomic analysis of the bovine and human ciliary zonule [PDF]
, 2016 PURPOSE: The zonule of Zinn (ciliary zonule) is a system of fibers that centers the crystalline lens on the optical axis of the eye. Mutations in zonule components underlie syndromic conditions associated with a broad range of ocular pathologies ...
Bassnett, Steven +3 more
core +2 more sources