Results 11 to 20 of about 5,505 (195)

A guide to building the matrisome interactome: from computational predictions to experimental validation. [PDF]

FEBS J
This guide proposes a roadmap combining state‐of‐the‐art computational and experimental approaches (including biophysical, biochemical, and imaging techniques) to identify, characterize, and contextualize extracellular matrix (ECM) protein interactions.
Leverton L, Bains AK, Isa I, Ricard-Blum S, Naba A.   +4 more
europepmc   +2 more sources

Brain region‐specific accumulation of amyloidosis‐associated proteins in postmortem brain tissues of Alzheimer's disease patients [PDF]

Alzheimers Dement
Abstract Background The matrisome is a comprehensive list of molecules that form and interact with the extracellular matrix (ECM). The matrisome includes not only structural proteins but also signaling molecules and regulators that that can modify the ECM.
Tsering W, Phillips J, Villareal J, Prokop S.   +3 more
europepmc   +3 more sources

Bone-Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation. [PDF]

Adv Healthc Mater
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Dekker M, Hipwood L, Ravichandran A, Hutmacher DW, Meinert C, McGovern J.   +5 more
europepmc   +2 more sources

Pan-cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors. [PDF]

Int J Cancer
What's new? Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Here, the authors leveraged tumor RNA‐seq data to identify molecular signatures of mechanical properties across various cancer types and build a computational model for predicting tumor matrix stiffness.
Tang G, Liu X, Li Y, Ta Y, Cho M, Li H, Wang X.   +6 more
europepmc   +2 more sources

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration. [PDF]

Adv Healthc Mater
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Xu J, Chiu PCN, Ng EHY, Hu S, Ye Z, Xin L, Ma L, Zhang S, Yeung WSB, Chan RWS.   +9 more
europepmc   +2 more sources

The Matrisome Genes From Hepatitis B–Related Hepatocellular Carcinoma Unveiled

Hepatology Communications, 2021
Chronic hepatitis B virus (HBV) infection changes the composition of the extracellular matrix (ECM) and enables the onset and progression of hepatocellular carcinoma (HCC).
Wei Chen, Romain Desert, Xiaodong Ge, Hui Han, Zhuolun Song, Sukanta Das, Dipti Athavale, Hong You, Natalia Nieto   +8 more
doaj   +1 more source

Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices

Frontiers in Bioengineering and Biotechnology, 2023
The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop.
Wei Chen, Wei Chen, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Shuyan Chen, Shuyan Chen, Tao Huang, Tao Huang, Hong You, Hong You   +11 more
doaj   +1 more source

Extracellular matrix gene expression signatures as cell type and cell state identifiers

Matrix Biology Plus, 2021
Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher, Christian Feregrino, Patrick Tschopp, Collin Y. Ewald   +3 more
doaj   +1 more source

Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers

Matrix Biology Plus, 2022
Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression.
Carson J. Cook, Andrew E. Miller, Thomas H. Barker, Yanming Di, Kaitlin C. Fogg   +4 more
doaj   +1 more source

Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data

Scientific Reports, 2021
The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues,
Tim O. Nieuwenhuis, Avi Z. Rosenberg, Matthew N. McCall, Marc K. Halushka   +3 more
doaj   +1 more source