Inflammation-related citrullination of matrisome proteins in human cancer
Frontiers in Oncology, 2022 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu +3 more
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In-silico definition of the Drosophila melanogaster matrisome
Matrix Biology Plus, 2019 The extracellular matrix (ECM) is an assembly of hundreds of proteins that structurally supports the cells it surrounds and biochemically regulates their functions.
Martin N. Davis +2 more
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Rare loss-of-function variants in matrisome genes are enriched in Ebstein’s anomaly
HGG Advances, 2023 Summary: Ebstein’s anomaly, a rare congenital heart disease, is distinguished by the failure of embryological delamination of the tricuspid valve leaflets from the underlying primitive right ventricle myocardium. Gaining insight into the genetic basis of
Zhou Zhou +7 more
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Pipeline for precise insoluble matrisome coverage in tissue extracellular matrices
Frontiers in Bioengineering and Biotechnology, 2023 The extracellular matrix (ECM) is assembled by hundreds of proteins orchestrating tissue patterning and surrounding cell fates via the mechanical–biochemical feedback loop.
Wei Chen +11 more
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The kidney matrisome in health, aging, and disease [PDF]
Kidney International, 2022 Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of aging and is associated with declining kidney function. Understanding these dynamic processes, in the hope of developing therapies to combat matrix dysregulation ...
Franziska Lausecker +2 more
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Degradomics technologies in matrisome exploration
Matrix Biology, 2022 Consisting of a defined set of extracellular proteins secreted from resident cells and with minor contributions from serum proteins, the extracellular matrix (ECM) is an essential component of all tissues. Maintaining tissue homeostasis, structural support and cellular control through cell-ECM communication, the ECM has come to be viewed as not just a ...
Aleksander M. Haack +2 more
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Matrisome remodeling in the myocardium of hypertrophic cardiomyopathy; novel targets for molecular diagnostics [PDF]
Frontiers in Cell and Developmental BiologyHypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder characterized by left ventricular thickening and extracellular matrix (ECM) remodeling, often manifested as increased interstitial fibrosis that impair muscle function.
Ayman M. Ibrahim +5 more
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Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma [PDF]
Scientific Reports, 2018 Increasing evidence demonstrates an important role for the extracellular matrix (ECM) in breast cancer progression. Collagen type I, a core constituent of the fibrous ECM, undergoes a significant set of changes that accompany tumor progression, termed ...
Lucas A. Tomko +8 more
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The matrisome landscape controlling in vivo germ cell fates
Nature CommunicationsThe developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development.
Aqilah Amran +5 more
doaj +3 more sources
MatriCom, a single-cell RNA-sequencing data mining tool to infer cell-extracellular matrix interactions. [PDF]
J Cell SciThe ECM is a complex meshwork of proteins forming the framework of all multicellular organisms. Protein interactions are critical to building and remodeling the ECM meshwork, while interactions between ECM proteins and receptors are essential to initiate
Lamba R +4 more
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