Results 31 to 40 of about 5,603 (226)

Extracellular matrix gene expression signatures as cell type and cell state identifiers

Matrix Biology Plus, 2021
Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher, Christian Feregrino, Patrick Tschopp, Collin Y. Ewald   +3 more
doaj   +1 more source

Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers

Matrix Biology Plus, 2022
Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression.
Carson J. Cook, Andrew E. Miller, Thomas H. Barker, Yanming Di, Kaitlin C. Fogg   +4 more
doaj   +1 more source

Comparative proteomic assessment of matrisome enrichment methodologies [PDF]

Biochemical Journal, 2016
The matrisome is a complex and heterogeneous collection of extracellular matrix (ECM) and ECM-associated proteins that play important roles in tissue development and homeostasis. While several strategies for matrisome enrichment have been developed, it is currently unknown how the performance of these different methodologies compares in the proteomic ...
Krasny, L, Paul, A, Wai, P, Howard, BA, Natrajan, RC, Huang, PH   +5 more
openaire   +3 more sources

Challenges and Opportunities Modeling the Dynamic Tumor Matrisome

BME Frontiers, 2023
We need novel strategies to target the complexity of cancer and, particularly, of metastatic disease. As an example of this complexity, certain tissues are particularly hospitable environments for metastases, whereas others do not contain fertile microenvironments to support cancer cell growth. Continuing evidence that the extracellular matrix (ECM) of
Peyton, Shelly R., Platt, Manu O., Cukierman, Edna   +2 more
openaire   +4 more sources

Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data

Scientific Reports, 2021
The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues,
Tim O. Nieuwenhuis, Avi Z. Rosenberg, Matthew N. McCall, Marc K. Halushka   +3 more
doaj   +1 more source

Fibroblast subtypes define a metastatic matrisome in breast cancer [PDF]

JCI Insight, 2020
Small primary breast cancers can show surprisingly high potential for metastasis. Clinical decision-making for tumor aggressiveness, including molecular profiling, relies primarily on analysis of the cancer cells. Here we show that this analysis is insufficient - that the stromal microenvironment of the primary tumor plays a key role in tumor cell ...
Heather M. Brechbuhl, Alexander Barrett, Etana Kopin, Jaime Hagen, Amy Han, Austin E. Gillen, Jessica Finlay-Schultz, Diana M. Cittelly, Philip Owens, Kathryn B. Horwitz, Carol A. Sartorius, Kirk C. Hansen, Peter Kabos   +12 more
openalex   +3 more sources

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]

, 2016
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA, Clarke, J, Eliceiri, KW, Ford, K, Frampton, S, Garcia, E, Gil, J, Hanley, CJ, Herranz, N, Kabir, TD, King, EV, Lambert, DW, Lim, KP, Mellone, M, Mellows, T, Moutasim, KA, Ottensmeier, CH, Prime, SS, Thirdborough, S, Thomas, GJ, Tod, J, Underwood, TJ, Venei, V, Venturi, G, Vijayanand, P, Woelk, C, Woo, J   +26 more
core   +5 more sources

Proteomic analysis of the bovine and human ciliary zonule [PDF]

, 2016
PURPOSE: The zonule of Zinn (ciliary zonule) is a system of fibers that centers the crystalline lens on the optical axis of the eye. Mutations in zonule components underlie syndromic conditions associated with a broad range of ocular pathologies ...
Bassnett, Steven, David, Larry L, De Maria, Alicia, Wilmarth, Phillip A   +3 more
core   +2 more sources

BMP2/BMPR1A is linked to tumour progression in dedifferentiated liposarcomas [PDF]

, 2016
Bone Morphogenic Protein 2 (BMP2) is a multipurpose cytokine, important in the development of bone and cartilage, and with a role in tumour initiation and progression.
Cassidy, A.P., Cassidy, J.W., Harris, O.B., O’Neill, H.L.   +3 more
core   +3 more sources

Sequential Inflammatory and Matrisome Programs Drive Remodeling of the Mouse Carotid-Jugular Arteriovenous Fistula. [PDF]

Cells
Stoyell-Conti FF, Kaiser AM, Rojas MG, Wei Y, Sussman MS, Lopez-McCormick JS, Tabbara M, Yang X, Vazquez-Padron RI, Martinez L.   +9 more
europepmc   +3 more sources