Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival [PDF]
, 2018 The extracellular microenvironment is an integral component of normal and diseased tissues that is poorly understood owing to its complexity. To investigate the contribution of the microenvironment to lung fibrosis and adenocarcinoma progression, two ...
Alexandra Naba +25 more
core +1 more source
Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer [PDF]
, 2016 The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic ...
Alanko +52 more
core +1 more source
In-silico definition of the Drosophila melanogaster matrisome
Matrix Biology Plus, 2019 The extracellular matrix (ECM) is an assembly of hundreds of proteins that structurally supports the cells it surrounds and biochemically regulates their functions.
Martin N. Davis +2 more
doaj +1 more source
Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress
Frontiers in Physiology, 2022 The periodontal ligament (PDL) is a specialized connective tissue that provides structural support to the tooth and is crucial for oral functions. The mechanical properties of the PDL are mainly derived from the tissue-specific composition and structural
Lay Thant +15 more
doaj +1 more source
Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response. [PDF]
Adv Sci (Weinh)Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Merkel MFR +11 more
europepmc +2 more sources
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients [PDF]
, 2016 We have previously identified UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer (TNBC) by mass spectrometry (MS).
Brask, J.B. (Julie Benedicte) +14 more
core +1 more source
Proteomic differences between native and tissue-engineered tendon and ligament [PDF]
, 2016 Tendons and ligaments (T/Ls) play key roles in the musculoskeletal system, but they are susceptible to traumatic or age‐related rupture, leading to severe morbidity as well as increased susceptibility to degenerative joint diseases such as osteoarthritis.
Adirim +48 more
core +1 more source
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-Derived Extracellular Matrix [PDF]
, 2017 The extracellular matrix (ECM) is recognized as a diverse, dynamic, and complex environment that is involved in multiple cell-physiological and pathological processes.
Adams, Josephine C +2 more
core +2 more sources
Replication confers β cell immaturity. [PDF]
, 2018 Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication.
Bengtsson, Henrik +9 more
core +5 more sources
Computational and Systems Oncology, 2022 Misexpression and remodeling of the extracellular matrix is a canonical hallmark of cancer, although the extent of cancer‐associated aberrations in the genes coding for extracellular matrix (ECM) proteins and the consequences thereof are not well ...
Jimpi Langthasa +4 more
doaj +1 more source