Results 41 to 50 of about 5,313 (152)

Shifting Responsibly: The Importance of Striatal Modularity to Reinforcement Learning in Uncertain Environments [PDF]

, 2010
We propose here that the modular organization of the striatum reflects a context-sensitive modular learning architecture in which clustered striosome–matrisome domains participate in modular reinforcement learning (RL).
Ken-ichi eAmemori, Ken-ichi eAmemori, Leif G. Gibb, Leif G. Gibb, Ann M. Graybiel, Ann M. Graybiel   +5 more
core   +1 more source

Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo

Biomolecules
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin.
Yan Yan, Hehui Quan, Chunfang Guo, Zhaoping Qin, Taihao Quan   +4 more
doaj   +1 more source

Insider Trading:Extracellular Matrix Proteins and their Non-Canonical Intracellular Roles [PDF]

, 2015
In metazoans, the extracellular matrix (ECM) provides a dynamic, heterogeneousmicroenvironment that has important supportive and instructive roles.
Adams, Josephine C, Hellewell, Andrew L
core   +2 more sources

Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression

Frontiers in Molecular Biosciences, 2022
The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression.
Ana M. Moreira, Ana M. Moreira, Ana M. Moreira, Rui M. Ferreira, Rui M. Ferreira, Patrícia Carneiro, Patrícia Carneiro, Joana Figueiredo, Joana Figueiredo, Hugo Osório, Hugo Osório, Hugo Osório, José Barbosa, José Barbosa, John Preto, John Preto, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Raquel Seruca, Raquel Seruca, Raquel Seruca   +25 more
doaj   +1 more source

A pan-cancer analysis of matrisome proteins reveals CTHRC1 and a related network as major ECM regulators across cancers.

PLoS ONE, 2022
The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy ...
Keerthi Harikrishnan, Srinivas Sheshagiri Prabhu, Nagaraj Balasubramanian   +2 more
doaj   +2 more sources

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

eLife, 2021
Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, and skin of ...
Yoanna Ariosa-Morejon, Alberto Santos, Roman Fischer, Simon Davis, Philip Charles, Rajesh Thakker, Angus KT Wann, Tonia L Vincent   +7 more
doaj   +1 more source

Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes [PDF]

, 2014
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed ...
Beaufort, C.M. (Corine M.), Berns, P.M.J.J. (Els), Besselink, N. (Nicolle), Brenton, J.D. (James D.), Heine, A.A.J. (Anouk), Helleman, J. (Jozien), Helmijr, J. (Jean), Hoogstraat, M. (Marlous), IJcken, W.F.J. (Wilfred) van, Koudijs, M.J. (Marco J.), Murtaza, M. (Muhammed), Piskorz, A.M. (Anna M.), Ruigrok-Ritstier, K. (Kirsten), Smid, M. (Marcel)   +13 more
core   +1 more source

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]

, 2019
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O., Gudkov, Andrei V., Hall, Brandon M., Krishnamurthy, Janakiraman, Liu, Jie-Yu, Parker, Joel S., Sessions, Garrett A., Sharpless, Norman E., Sorrentino, Jessica A., Souroullas, George P.   +9 more
core   +3 more sources

Atlas of mildly and highly insoluble matrisome driving liver fibrosis

Frontiers in Pharmacology
The excessive deposition and cross-linking of core matrisome components typically result in abnormal remodeling of the extracellular matrix (ECM), leading to increased liver stiffness and worsening liver fibrosis.
Wen Zhang, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Ning Zhang, Wenyue Wu, Wenyue Wu, Wenyue Wu, Hong Li, Hong Li, Hong Li, Hong Li, Hong You, Hong You, Hong You, Wei Chen, Wei Chen, Wei Chen, Wei Chen, Wei Chen   +20 more
doaj   +1 more source

Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis

Frontiers in Cell and Developmental Biology, 2021
Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging.
Mansheng Li, Xiao Li, Binghui Liu, Luye Lv, Wenjuan Wang, Dunqin Gao, Qiyu Zhang, Junyi Jiang, Mi Chai, Zhimin Yun, Yingxia Tan, Feng Gong, Zhihong Wu, Yunping Zhu, Yunping Zhu, Jie Ma, Ling Leng   +16 more
doaj   +1 more source