Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters [PDF]
, 2013 The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing ...
Anastassiades +58 more
core +2 more sources
Matrix Biology Plus, 2019 Proteins are the building blocks of life. While proteins and their localization within cells and sub-cellular compartments are well defined, the proteins predicted to be secreted to form the extracellular matrix - or matrisome - remain elusive in the ...
Alina C. Teuscher +6 more
doaj +1 more source
Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer
Frontiers in Oncology, 2021 A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome.
Priyanka Hirani +4 more
doaj +1 more source
Biomedicines, 2022 FoxL1+telocytes (TCFoxL1+) are novel gastrointestinal subepithelial cells that form a communication axis between the mesenchyme and epithelium. TCFoxL1+ are strategically positioned to be key contributors to the microenvironment through production and ...
Alain B. Alfonso +6 more
doaj +1 more source
Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival [PDF]
, 2018 The extracellular microenvironment is an integral component of normal and diseased tissues that is poorly understood owing to its complexity. To investigate the contribution of the microenvironment to lung fibrosis and adenocarcinoma progression, two ...
Alexandra Naba +25 more
core +1 more source
Frontiers in Aging, 2022 Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling
Tinka Vidović, Collin Y. Ewald
doaj +1 more source
Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer [PDF]
, 2016 The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic ...
Alanko +52 more
core +1 more source
In-silico definition of the Drosophila melanogaster matrisome
Matrix Biology Plus, 2019 The extracellular matrix (ECM) is an assembly of hundreds of proteins that structurally supports the cells it surrounds and biochemically regulates their functions.
Martin N. Davis +2 more
doaj +1 more source
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-Derived Extracellular Matrix [PDF]
, 2017 The extracellular matrix (ECM) is recognized as a diverse, dynamic, and complex environment that is involved in multiple cell-physiological and pathological processes.
Adams, Josephine C +2 more
core +1 more source
The Arbitration–Extension Hypothesis: A Hierarchical Interpretation of the Functional Organization of the Basal Ganglia [PDF]
, 2011 Based on known anatomy and physiology, we present a hypothesis where the basal ganglia motor loop is hierarchically organized in two main subsystems: the arbitration system and the extension system.
Iman Kamali Sarvestani +3 more
core +2 more sources