Results 41 to 50 of about 5,505 (195)

Proteomic differences between native and tissue-engineered tendon and ligament [PDF]

, 2016
Tendons and ligaments (T/Ls) play key roles in the musculoskeletal system, but they are susceptible to traumatic or age‐related rupture, leading to severe morbidity as well as increased susceptibility to degenerative joint diseases such as osteoarthritis.
Adirim, Ahmed, Bancroft, Bayer, Benjamin, Bergman, Beynnon, Birch, Burt, Butler, Calve, Canty, Canty, Cimino, Clegg, Comerford, Daniel, Farndale, Franceschini, Funakoshi, Hagerty, Herchenhan, Herchenhan, Hynes, Kapacee, Kapacee, Little, Maffulli, Maffulli, Mastrokalos, Naba, Paxton, Paxton, Peffers, Peffers, Raspanti, Rees, Reichenberg, Robertson, Rodrigues, Singer, Smith, Spindler, Strickland, Thorpe, Vogel, Woo, Young, Zhang   +48 more
core   +1 more source

Replication confers β cell immaturity. [PDF]

, 2018
Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication.
Bengtsson, Henrik, French, Esra K, Hebrok, Matthias, Leonhardt, Laura, Puri, Sapna, Roy, Nilotpal, Roy, Ritu, Russ, Holger A, Scott, Donald K, Stewart, Andrew F   +9 more
core   +5 more sources

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-Derived Extracellular Matrix [PDF]

, 2017
The extracellular matrix (ECM) is recognized as a diverse, dynamic, and complex environment that is involved in multiple cell-physiological and pathological processes.
Adams, Josephine C, Hellewell, Andrew L, Rosini, Silvia   +2 more
core   +2 more sources

Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients [PDF]

, 2016
We have previously identified UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer (TNBC) by mass spectrometry (MS).
Brask, J.B. (Julie Benedicte), Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Foekens, R. (Renée), Liu, N.Q. (Ning Qing), Look, M.P. (Maxime), Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Smid, M. (Marcel), Span, P.N. (Paul), Sweep, F.C. (Fred), Timmermans, A.M. (Annemieke), Timmermans-Wielenga, V. (Vera), Trapman-Jansen, A.M.A.C. (Anita M.A.C.), Umar, A. (Arzu)   +14 more
core   +1 more source

Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo

Biomolecules
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin.
Yan Yan, Hehui Quan, Chunfang Guo, Zhaoping Qin, Taihao Quan   +4 more
doaj   +1 more source

Insider Trading:Extracellular Matrix Proteins and their Non-Canonical Intracellular Roles [PDF]

, 2015
In metazoans, the extracellular matrix (ECM) provides a dynamic, heterogeneousmicroenvironment that has important supportive and instructive roles.
Adams, Josephine C, Hellewell, Andrew L
core   +2 more sources

Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes [PDF]

, 2014
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed ...
Beaufort, C.M. (Corine M.), Berns, P.M.J.J. (Els), Besselink, N. (Nicolle), Brenton, J.D. (James D.), Heine, A.A.J. (Anouk), Helleman, J. (Jozien), Helmijr, J. (Jean), Hoogstraat, M. (Marlous), IJcken, W.F.J. (Wilfred) van, Koudijs, M.J. (Marco J.), Murtaza, M. (Muhammed), Piskorz, A.M. (Anna M.), Ruigrok-Ritstier, K. (Kirsten), Smid, M. (Marcel)   +13 more
core   +1 more source

A pan-cancer analysis of matrisome proteins reveals CTHRC1 and a related network as major ECM regulators across cancers.

PLoS ONE, 2022
The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy ...
Keerthi Harikrishnan, Srinivas Sheshagiri Prabhu, Nagaraj Balasubramanian   +2 more
doaj   +2 more sources

Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression

Frontiers in Molecular Biosciences, 2022
The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression.
Ana M. Moreira, Ana M. Moreira, Ana M. Moreira, Rui M. Ferreira, Rui M. Ferreira, Patrícia Carneiro, Patrícia Carneiro, Joana Figueiredo, Joana Figueiredo, Hugo Osório, Hugo Osório, Hugo Osório, José Barbosa, José Barbosa, John Preto, John Preto, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Raquel Seruca, Raquel Seruca, Raquel Seruca   +25 more
doaj   +1 more source

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

eLife, 2021
Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, and skin of ...
Yoanna Ariosa-Morejon, Alberto Santos, Roman Fischer, Simon Davis, Philip Charles, Rajesh Thakker, Angus KT Wann, Tonia L Vincent   +7 more
doaj   +1 more source