Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters [PDF]
, 2013 The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing ...
Anastassiades +58 more
core +2 more sources
Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival [PDF]
, 2018 The extracellular microenvironment is an integral component of normal and diseased tissues that is poorly understood owing to its complexity. To investigate the contribution of the microenvironment to lung fibrosis and adenocarcinoma progression, two ...
Alexandra Naba +25 more
core +1 more source
Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer [PDF]
, 2016 The extracellular matrix (ECM) is a network of secreted proteins that, beyond providing support for tissues and organs, is involved in the regulation of a variety of cell functions, including cell proliferation, polarity, migration and oncogenic ...
Alanko +52 more
core +1 more source
Proteomics, Glycomics, and Glycoproteomics of Matrisome Molecules
Molecular & Cellular Proteomics, 2019 The most straightforward applications of proteomics database searching involve intracellular proteins. Although intracellular gene products number in the thousands, their well-defined post-translational modifications (PTMs) makes database searching practical.
Rekha Raghunathan +3 more
openaire +2 more sources
Matrisome Deregulation in Ovarian Cancer Metastasis
Proceedings of IMPRS, 2020 Background and Hypothesis: Over 75% of ovarian cancer (OC) patients present with metastasis upon initial diagnosis. Since most are treated for metastatic disease, it is crucial that developing therapies target metastasis. Our analysis of OC transcriptomic changes revealed key changes in the matrisome.
Jessica Tedrow, Ji Wang, Anirban Mitra
openaire +2 more sources
Age-Related Changes in the Matrisome of the Mouse Skeletal Muscle [PDF]
International Journal of Molecular Sciences, 2021 Aging is characterized by a progressive decline of skeletal muscle (SM) mass and strength which may lead to sarcopenia in older persons. To date, a limited number of studies have been performed in the old SM looking at the whole, complex network of the extracellular matrix (i.e., matrisome) and its aging-associated changes.
Francesco Demetrio Lofaro +7 more
openaire +4 more sources
Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress
Frontiers in Physiology, 2022 The periodontal ligament (PDL) is a specialized connective tissue that provides structural support to the tooth and is crucial for oral functions. The mechanical properties of the PDL are mainly derived from the tissue-specific composition and structural
Lay Thant +15 more
doaj +1 more source
The Arbitration–Extension Hypothesis: A Hierarchical Interpretation of the Functional Organization of the Basal Ganglia [PDF]
, 2011 Based on known anatomy and physiology, we present a hypothesis where the basal ganglia motor loop is hierarchically organized in two main subsystems: the arbitration system and the extension system.
Iman Kamali Sarvestani +3 more
core +2 more sources
Replication confers β cell immaturity. [PDF]
, 2018 Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication.
Bengtsson, Henrik +9 more
core +5 more sources
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-Derived Extracellular Matrix [PDF]
, 2017 The extracellular matrix (ECM) is recognized as a diverse, dynamic, and complex environment that is involved in multiple cell-physiological and pathological processes.
Adams, Josephine C +2 more
core +2 more sources