Results 51 to 60 of about 5,938 (234)

Proteomic differences between native and tissue-engineered tendon and ligament [PDF]

, 2016
Tendons and ligaments (T/Ls) play key roles in the musculoskeletal system, but they are susceptible to traumatic or age‐related rupture, leading to severe morbidity as well as increased susceptibility to degenerative joint diseases such as osteoarthritis.
Adirim, Ahmed, Bancroft, Bayer, Benjamin, Bergman, Beynnon, Birch, Burt, Butler, Calve, Canty, Canty, Cimino, Clegg, Comerford, Daniel, Farndale, Franceschini, Funakoshi, Hagerty, Herchenhan, Herchenhan, Hynes, Kapacee, Kapacee, Little, Maffulli, Maffulli, Mastrokalos, Naba, Paxton, Paxton, Peffers, Peffers, Raspanti, Rees, Reichenberg, Robertson, Rodrigues, Singer, Smith, Spindler, Strickland, Thorpe, Vogel, Woo, Young, Zhang   +48 more
core   +1 more source

Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress

Science Advances, 2023
Hyperosmotic stress occurs in several diseases, but its long-term effects are largely unknown. We used sorbitol-treated human fibroblasts in 3D culture to study the consequences of hyperosmotic stress in the skin.
Catharina S Sänger, Martina Cernakova, Mateusz S. Wietecha, Lorenza Garau Paganella, Céline Labouesse, Oksana Y. Dudaryeva, C. Roubaty, M. Stumpe, E. Mazza, M. Tibbitt, J. Dengjel, Sabine Werner   +11 more
semanticscholar   +1 more source

Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression

Frontiers in Molecular Biosciences, 2022
The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression.
Ana M. Moreira, Ana M. Moreira, Ana M. Moreira, Rui M. Ferreira, Rui M. Ferreira, Patrícia Carneiro, Patrícia Carneiro, Joana Figueiredo, Joana Figueiredo, Hugo Osório, Hugo Osório, Hugo Osório, José Barbosa, José Barbosa, John Preto, John Preto, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Raquel Seruca, Raquel Seruca, Raquel Seruca   +25 more
doaj   +1 more source

Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients [PDF]

, 2016
We have previously identified UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer (TNBC) by mass spectrometry (MS).
Brask, J.B. (Julie Benedicte), Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Foekens, R. (Renée), Liu, N.Q. (Ning Qing), Look, M.P. (Maxime), Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Smid, M. (Marcel), Span, P.N. (Paul), Sweep, F.C. (Fred), Timmermans, A.M. (Annemieke), Timmermans-Wielenga, V. (Vera), Trapman-Jansen, A.M.A.C. (Anita M.A.C.), Umar, A. (Arzu)   +14 more
core   +1 more source

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

eLife, 2021
Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, and skin of ...
Yoanna Ariosa-Morejon, Alberto Santos, Roman Fischer, Simon Davis, Philip Charles, Rajesh Thakker, Angus KT Wann, Tonia L Vincent   +7 more
doaj   +1 more source

Deciphering the Kidney Matrisome: Identification and Quantification of Renal Extracellular Matrix Proteins in Healthy Mice

International Journal of Molecular Sciences, 2023
Precise characterization of a tissue’s extracellular matrix (ECM) protein composition (matrisome) is essential for biomedicine. However, ECM protein extraction that requires organ-specific optimization is still a major limiting factor in matrisome ...
Umut Rende, S. Ahn, Subash Adhikari, Edward S. X. Moh, C. Pollock, S. Saad, Adnan Guller   +6 more
semanticscholar   +1 more source

A pan-cancer analysis of matrisome proteins reveals CTHRC1 and a related network as major ECM regulators across cancers.

PLoS ONE, 2022
The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy ...
Keerthi Harikrishnan, Srinivas Sheshagiri Prabhu, Nagaraj Balasubramanian   +2 more
doaj   +2 more sources

Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes [PDF]

, 2014
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed ...
Beaufort, C.M. (Corine M.), Berns, P.M.J.J. (Els), Besselink, N. (Nicolle), Brenton, J.D. (James D.), Heine, A.A.J. (Anouk), Helleman, J. (Jozien), Helmijr, J. (Jean), Hoogstraat, M. (Marlous), IJcken, W.F.J. (Wilfred) van, Koudijs, M.J. (Marco J.), Murtaza, M. (Muhammed), Piskorz, A.M. (Anna M.), Ruigrok-Ritstier, K. (Kirsten), Smid, M. (Marcel)   +13 more
core   +1 more source

TGF-β controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription in mice

Journal of Clinical Investigation
Premature birth disrupts normal lung development and places infants at risk for bronchopulmonary dysplasia (BPD), a disease disrupting lung health throughout the life of an individual and that is increasing in incidence.
Danielle A. Callaway, Ian J. Penkala, Su Zhou, Jonathan J Knowlton, F. Cardenas-Diaz, A. Babu, M. Morley, Mariana Lopes, Benjamin A Garcia, Edward E. Morrisey   +9 more
semanticscholar   +1 more source

Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis

Frontiers in Cell and Developmental Biology, 2021
Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging.
Mansheng Li, Xiao Li, Binghui Liu, Luye Lv, Wenjuan Wang, Dunqin Gao, Qiyu Zhang, Junyi Jiang, Mi Chai, Zhimin Yun, Yingxia Tan, Feng Gong, Zhihong Wu, Yunping Zhu, Yunping Zhu, Jie Ma, Ling Leng   +16 more
doaj   +1 more source