Results 51 to 60 of about 5,313 (152)

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition [PDF]

, 2016
This study was funded by the BBSRC (BB/K008412/1)
A Franceschini, A Heinz, A Heinz, AA Biewener, B Kim, B Poulet, CT Thorpe, CT Thorpe, CT Thorpe, D Little, ER Ely, GA Lichtwark, H Mi, HL Birch, HL Birch, J Halper, J Melrose, JA Vizcaíno, JF Innes, JL Ireland, JM Whitelock, K Halasz, KE Kadler, KM Heinemeier, L Svensson, M Peffers, MJ Peffers, MJ Peffers, PE Hall, PJ Roughley, PPY Lui, PR Stephens, R Strocchi, RAE Clayton, RC Dwivedi, RK Smith, RM Korol, RO Hynes, S Kalamajski, SG Rees, SH Taylor, T Can, TM Grant, TM Ritty, X Liu, Y Kasashima, Y Sun, Y-L Sun   +47 more
core   +3 more sources

Immune‐related matrisomes are potential biomarkers to predict the prognosis and immune microenvironment of glioma patients

FEBS Open Bio, 2023
The extracellular matrix (ECM) plays a vital role in the progression and metastasis of glioma and is an important part of the tumor microenvironment. The matrisome is composed of ECM components and related proteins. There have been several studies on the
Hao Yu, Minjie Wang, Xuan Wang, Xiaobing Jiang   +3 more
doaj   +1 more source

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer

Frontiers in Oncology, 2023
IntroductionThe composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through multiple
Helen F. Titmarsh, Helen F. Titmarsh, Alex von Kriegsheim, Jimi C. Wills, Richard A. O’Connor, Kevin Dhaliwal, Margaret C. Frame, Samuel B. Pattle, David A. Dorward, David A. Dorward, Adam Byron, Adam Byron, Ahsan R. Akram, Ahsan R. Akram   +13 more
doaj   +1 more source

The Pathway Coexpression Network: Revealing pathway relationships. [PDF]

, 2018
A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions.
A Alexeyenko, A Alexeyenko, A Brazma, A Burns, A Kumar, A Lewin, A Liberzon, A Naba, A Pujol, A Subramanian, A Thakur, A Zambrano, AA Sharov, AL Barabási, AL Barabási, B Efron, B Schreitmüller, C Ogris, CF Schaefer, Christina S. Leslie, Claire Green, D Croft, D Izawa, D Merico, D Nishimura, D Paris, D Warde-Farley, DR Rhodes, DR Rhodes, E Clough, E Eisenberg, FH Duits, FX Lepelletier, G Stelzer, Gabriel Altschuler, GE Landreth, GM Altschuler, GV Glazko, H Naeem, H Pearson, H Yan, HJM de Jonge, HR Frost, HR Frost, HS Le, J Caltagarone, J Dutkowski, J Pevsner, J Rung, J Schäfer, J Seita, J Weinstein, J Weinstein, JC Vivar, JF Rual, JH Hung, JS Miners, JT Leek, Katjuša Koler, KG Becker, L Matthews, L Thorrez, LG Bodea, M Ashburner, M de Jager, M Kanehisa, M Kanehisa, M Kanehisa, M Kramer, M Lukk, M Morawski, M Schena, ME Orcholski, MJ Macias, MJ Végh, MK Sethi, MM Almeida-de Macedo, MMM Wilhelmus, MN McCall, MN McCall, MN McCall, O Berezovska, O Ledoit, P Di Lena, P Scheltens, PL McGeer, R Isserlin, R Sherrington, R von Bernhardi, RJ Kelleher, RM Ewing, Rudolph E. Tanzi, S Bauer, S Catricala, S Davis, S Draghici, S Falcon, S Gaubatz, S Grossmann, S Lu, S Maere, S Ranganathan, Sokratis Kariotis, SY Kim, T Barrett, T Liptak, T McCormack, T Wang, TM Loughin, U Hassler, U Stelzl, V Popovici, VK Ramanan, W Fujibuchi, W Zhang, Wenbin Wei, Winston Hide, WR Markesbery, WS Liang, WT Barry, Y Benjamini, Y Huang, Y Kong, Y Li, Y Liu, Y Lu, Y Pritykin, Y Tan, Y Yamaguchi, Y Yu, Yered Pita-Juárez   +130 more
core   +4 more sources

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Cell Reports, 2022
Summary: In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression.
Elizabeth R. Murray, Shinelle Menezes, Jack C. Henry, Josie L. Williams, Lorena Alba-Castellón, Priththivika Baskaran, Ivan Quétier, Ami Desai, Jacqueline J.T. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward P. Carter, Kairbaan Hodivala-Dilke, Richard P. Grose, Hemant M. Kocher, Nuria Gavara, Oliver Pearce, Pedro Cutillas, John F. Marshall, Angus J.M. Cameron   +26 more
doaj   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

The matrisome landscape controlling in vivo germ cell fates

Nature Communications
The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development.
Aqilah Amran, Lara Pigatto, Johanna Farley, Rasoul Godini, Roger Pocock, Sandeep Gopal   +5 more
doaj   +1 more source

The evolution of metazoan extracellular matrix [PDF]

, 2011
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins.
Adams, Aouacheria, Ball, Barros, Bentley, Bergmeier, Boute, Chapman, Chiquet-Ehrismann, Couchman, Dehal, Engel, Ewan, Exposito, Exposito, Fahey, Gazave, Heino, Hohenester, Huhtala, Hutter, Huxley-Jones, Hynes, Hynes, Hynes, Hynes, King, King, Knack, Martindale, Merline, Myllyharju, Naba, Ozbek, Patthy, Philippe, Philippe, Pick, Putnam, Putnam, Ricard-Blum, Richard O. Hynes, Robertson, Sadler, Schaefer, Schierwater, Sebé-Pedrós, Shalchian-Tabrizi, Srivastava, Srivastava, Tucker, Wada, Whittaker, Whittaker, Yurchenco, Zhang   +55 more
core   +1 more source