Results 11 to 20 of about 151,660 (257)

Influence of phase I periodontal therapy on levels of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinase 1

Saudi Dental Journal, 2014
Background: Matrix metalloproteinase-1 (MMP-1) is a member of a family of enzymes that can degrade most extracellular matrix macromolecules. Extracellularly, MMPs are controlled by tissue inhibitors of metalloproteinases (TIMPs) and by mechanisms of pro ...
Pallavi S. Ghodpage, Rajashri A. Kolte, Abhay P. Kolte, Madhur Gupta   +3 more
doaj   +3 more sources

Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1. [PDF]

Chemphyschem, 2023
AbstractThe front cover artwork is provided by Dr. Karabencheva‐Christova's group at Michigan Technological University. The images show the initially formed and the catalytically productive conformations of MMP‐1 complex with the Triple Helical Peptide (THP), the free energy profile connecting them as well as the coordination geometry of the catalytic ...
Waheed SO, Varghese A, DiCastri I, Kaski B, LaRouche C, Fields GB, Karabencheva-Christova TG.   +6 more
europepmc   +5 more sources

Examination of Matrix Metalloproteinase-1 in Solution [PDF]

Journal of Biological Chemistry, 2013
The journal of biological chemistry 288(42), 30659 - 30671 (2013).
Linda Cerofolini, Gregg B. Fields, Marco Fragai, Carlos F.G.C. Geraldes, Claudio Luchinat, Giacomo Parigi, Enrico Ravera, Dmitri I. Svergun, João M.C. Teixeira   +8 more
openaire   +4 more sources

Structural Basis for Matrix Metalloproteinase 1-Catalyzed Collagenolysis [PDF]

Journal of the American Chemical Society, 2012
The proteolysis of collagen triple-helical structure (collagenolysis) is a poorly understood yet critical physiological process. Presently, matrix metalloproteinase 1 (MMP-1) and collagen triple-helical peptide models have been utilized to characterize the events and calculate the energetics of collagenolysis via NMR spectroscopic analysis of 12 enzyme-
BERTINI, IVANO, FRAGAI, MARCO, LUCHINAT, CLAUDIO, MELIKIAN, MAXIME THIERRY OLIVIER, TOCCAFONDI, MIRCO, J. L. Lauer, G. B. Fields   +6 more
openaire   +3 more sources

Role of matrix metalloproteinases 1, 2, and 9 and tissue inhibitor of matrix metalloproteinase-1 in chronic venous insufficiency [PDF]

Journal of Vascular Surgery, 2001
Increased transforming growth factor-beta(1) (TGF-beta(1)) activity is associated with chronic venous insufficiency (CVI) disease progression and dermal skin pathology. Because TGF-beta(1) stimulates collagen synthesis and alters the levels of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), we investigated the hypothesis that increased ...
Saito, Satoshi, Trovato, Matthew J., You, Ruoxu, Lal, Brajesh K., Fasehun, Funmi, Padberg, Frank T., Hobson, Robert W., Durán, Walter N., Pappas, Peter J.   +8 more
openaire   +2 more sources

Matrix metalloproteinase‐1 contribution to sarcoma cell invasion [PDF]

Journal of Cellular and Molecular Medicine, 2012
AbstractMatrix metalloproteinase‐1 (MMP‐1) activity has been linked to numerous disease processes from arthritis to ulcer. Its proteolytic activity has been implicated inconsistently in different steps of tumourigenesis and metastasis. The discrepancies may be attributable to our limited understanding of MMP‐1 production, cellular trafficking ...
Garamszegi, Nandor, Garamszegi, Susanna P, Scully, Sean P   +2 more
openaire   +2 more sources

Changes in Serum Levels of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Essential Hypertension. [PDF]

Bioengineering (Basel), 2022
Hypertension (HTN) is a leading risk factor for cardiovascular (CV) disease. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be actively involved in the remodeling of the CV extracellular matrix (ECM) during hypertensive damage.
Kostov K, Blazhev A.
europepmc   +4 more sources

Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran, Erik Biros, Smriti M. Krishna, Susan K. Morton, Daniel J. Sexton, Jonathan Golledge   +5 more
doaj   +1 more source

Expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in ulcerative colitis

World Journal of Gastroenterology, 2006
To examine the expression of metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the colonic mucosa of patients with ulcerative colitis (UC).Reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry were used to study the expression of MMP-1 and TIMP-1 at both mRNA and protein levels in patients ...
Ying-De, Wang, Pei-Yun, Yan
openaire   +2 more sources

Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling

Frontiers in Immunology, 2018
Airway remodeling is responsible for the progressive decline of lung function in bronchial asthma. Matrix metalloproteinase-2 and fibroblast-to-myofibroblast transition are involved in tissue remodeling.
Yu Kuwabara, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Atsuro Takeshita, Hajime Fujimoto, Mizuho Nagao, Takao Fujisawa, Esteban C. Gabazza   +10 more
doaj   +1 more source