Results 11 to 20 of about 246,662 (308)

Effect of small interfering RNAs on matrix metalloproteinase 1 expression

Biotechnology Reports, 2014
Three small double strand siRNAs (506-MMP1, 859-MMP1 and 891-MMP1), each contains 25–26 nucleotides, with high specific to human MMP1 were designed according to mRNA sequence of human MMP1 (NCBI, NM_002421). To monitor the MMP1 gene expression, the total
Gen-Hung Chen, Chun-Hua Huang, Huang-Yao Luo, Shann-Tzong Jiang   +3 more
doaj   +3 more sources

Structural Basis for Matrix Metalloproteinase 1-Catalyzed Collagenolysis [PDF]

Journal of the American Chemical Society, 2012
The proteolysis of collagen triple-helical structure (collagenolysis) is a poorly understood yet critical physiological process. Presently, matrix metalloproteinase 1 (MMP-1) and collagen triple-helical peptide models have been utilized to characterize the events and calculate the energetics of collagenolysis via NMR spectroscopic analysis of 12 enzyme-
BERTINI, IVANO, FRAGAI, MARCO, LUCHINAT, CLAUDIO, MELIKIAN, MAXIME THIERRY OLIVIER, TOCCAFONDI, MIRCO, J. L. Lauer, G. B. Fields   +6 more
openaire   +3 more sources

Matrix metalloproteinase‐1 contribution to sarcoma cell invasion [PDF]

Journal of Cellular and Molecular Medicine, 2012
AbstractMatrix metalloproteinase‐1 (MMP‐1) activity has been linked to numerous disease processes from arthritis to ulcer. Its proteolytic activity has been implicated inconsistently in different steps of tumourigenesis and metastasis. The discrepancies may be attributable to our limited understanding of MMP‐1 production, cellular trafficking ...
Garamszegi, Nandor, Garamszegi, Susanna P, Scully, Sean P   +2 more
openaire   +2 more sources

Vascular tube formation on matrix metalloproteinase-1-damaged collagen [PDF]

British Journal of Cancer, 2008
Endothelial cells maintained on a three‐dimensional lattice of intact, polymerized type I collagen formed a monolayer of cells with a cobblestone morphology. When the collagen was exposed to organ culture fluid from human skin (previously characterized and shown to contain a high level of active matrix metalloproteinase‐1 [MMP‐1]), degradation of the ...
Varani, J, Perone, P, Warner, R L, Dame, M K, Kang, S, Fisher, G J, Voorhees, J J   +6 more
openaire   +2 more sources

Association of Matrix Metalloproteinase-1 Genotypes With Bladder Cancer Risk. [PDF]

In Vivo, 2021
There is very little literature reporting the association of matrix metalloproteinase-1 (MMP1) with personal susceptibility to bladder cancer. In the current study, we carried out the first examination of the contribution of MMP1 rs1799750 to bladder cancer risk in Taiwanese.A total of 375 bladder cancer cases and 375 healthy controls were genotyped ...
Liao CH, Tsai CW, Chang WS, Wang ZH, Gong CL, Wu HC, Wang BR, Hsu SW, Huang WC, Shen TC, Bau DT.   +10 more
europepmc   +4 more sources

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K., Grone H. J., Luboshits G., Nagase H., Stetler-Stevenson W. G., Stetler-Stevenson W. G., Urdiales-Viedma M., Zhang Y.   +7 more
core   +1 more source

Role of matrix metalloproteinases 1, 2, and 9 and tissue inhibitor of matrix metalloproteinase-1 in chronic venous insufficiency [PDF]

Journal of Vascular Surgery, 2001
Increased transforming growth factor-beta(1) (TGF-beta(1)) activity is associated with chronic venous insufficiency (CVI) disease progression and dermal skin pathology. Because TGF-beta(1) stimulates collagen synthesis and alters the levels of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), we investigated the hypothesis that increased ...
Saito, Satoshi, Trovato, Matthew J., You, Ruoxu, Lal, Brajesh K., Fasehun, Funmi, Padberg, Frank T., Hobson, Robert W., Durán, Walter N., Pappas, Peter J.   +8 more
openaire   +2 more sources

Kallikrein‐1 Blockade Inhibits Aortic Expansion in a Mouse Model and Reduces Prostaglandin E2 Secretion From Human Aortic Aneurysm Explants

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran, Erik Biros, Smriti M. Krishna, Susan K. Morton, Daniel J. Sexton, Jonathan Golledge   +5 more
doaj   +1 more source

A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease [PDF]

, 2007
Dupuytren’s disease (DD) is a common fibrotic condition of the palmar fascia, leading to deposition of collagen-rich cords and finger contractions. The metzincin superfamily contains key enzymes in the turnover of collagen and other extracellular matrix ...
Adrian J. Chojnowski, Baker, Baragi, Bird, Bisson, Bretz, Brinckerhoff, Brown, Bunker, Clark, Daniels, Drummond, d’Ortho, Graham P. Riley, Hutchinson, Ian M. Clark, Iredale, Jones, Jung, Kashiwagi, Kevorkian, Knauper, Le Goff, Luck, Mikkelsen, Mirastschijski, Moyer, Murphy, Nuttall, Ohuchi, Phillip Johnston, Porter, Porter, Price, Qian, Rayan, Rose K. Davidson, Schaer, Scott, Simon T. Donell, Smith, Tarlton, Tarpila, Thurston, Ulrich, Unemori, Unemori, Unemori, Williams   +48 more
core   +1 more source

Increased Matrix Metalloproteinase-2 and Matrix Metalloproteinase-3 Concentrations in Corneal Epithelium of Patients with Recurrent Corneal Erosions

Journal of Ophthalmology, 2022
Purpose. To assess the role of selected matrix metalloproteinases in defective corneal re-epithelization in patients with recurrent corneal erosions. Subjects.
Katarzyna Jadczyk-Sorek, Wojciech Garczorz, Beata Bubała-Stachowicz, Tomasz Francuz, Ewa Mrukwa-Kominek   +4 more
doaj   +1 more source