Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. The kinin B2 receptor agonist, bradykinin, has been implicated in AAA pathogenesis through promoting inflammation.
Corey S. Moran +5 more
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Cell surface engineering of renal cell carcinoma with glycosylphosphatidylinositol-anchored TIMP-1 blocks TGF-beta 1 activation and reduces regulatory ID gene expression [PDF]
, 2012 Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the ...
Notohamiprodjo, Susan +5 more
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Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling
Frontiers in Immunology, 2018 Airway remodeling is responsible for the progressive decline of lung function in bronchial asthma. Matrix metalloproteinase-2 and fibroblast-to-myofibroblast transition are involved in tissue remodeling.
Yu Kuwabara +10 more
doaj +1 more source
Journal of Ophthalmology, 2022 Purpose. To assess the role of selected matrix metalloproteinases in defective corneal re-epithelization in patients with recurrent corneal erosions. Subjects.
Katarzyna Jadczyk-Sorek +4 more
doaj +1 more source
World Journal of Gastroenterology, 2006 To examine the expression of metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the colonic mucosa of patients with ulcerative colitis (UC).Reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry were used to study the expression of MMP-1 and TIMP-1 at both mRNA and protein levels in patients ...
Ying-De, Wang, Pei-Yun, Yan
openaire +2 more sources
Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]
, 2011 Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller +9 more
core +1 more source
Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer
Tumor Biology, 2018 Despite gastric cancer being rare nowadays in Western countries, it remains one of the leading causes of cancer death worldwide. The course of the disease varies, so the individual gastric cancer patient’s prognosis is difficult to determine.
Alli Laitinen +7 more
doaj +1 more source
Cardiotrophin-1 induces matrix metalloproteinase-1 in human aortic endothelial cells. [PDF]
PLoS ONE, 2013 Rupture of an atherosclerotic plaque is a key event in the development of cardiovascular disorders, in which matrix metalloproteinase-1 (MMP-1) plays a crucial role by degradation of extracellular matrix resulting in plaque instability.
Akinori Tokito +3 more
doaj +1 more source
Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]
, 2007 MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Mentele, Reinhard +6 more
core +1 more source
Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1 [PDF]
, 2000 Bachmeier BE, Nerlich AG, Boukamp P, et al. Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1. BIOLOGICAL CHEMISTRY.
Boukamp, P +13 more
core +1 more source