Results 101 to 110 of about 188,223,062 (256)

Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young. [PDF]

, 2012
OBJECTIVE: Misdiagnosis of maturity-onset diabetes of the young (MODY) remains widespread, despite the benefits of optimized management. This cross-sectional study examined diagnostic misclassification of MODY in subjects with clinically labeled young ...
Bingley, PJ, Selwood, MP, McCarthy, MI, Farmer, AJ, Fisher, K, Thanabalasingham, G, Owen, KR, Dudley, C, Ellard, S, Pal, A   +9 more
core   +1 more source

A Single Nucleotide Variant in HNF-1β is associated with Maturity-Onset Diabetes of the Young in a Large Chinese Family

Iranian Journal of Public Health, 2016
Background: Maturity-onset diabetes of the young (MODY) is a heterogeneous entity of monogenic disorders characterized by autosomal dominant inheritance.
Peng ZHOU, Ran WEI, Zhenkui GUO, Haining ZHU, Desmond CAMPBELL, Qi LI, Xiaoqun XU, Junfu WANG, Meng LUAN, Xing CHEN, Gang CHEN   +10 more
doaj  

Management and outcomes in pregnant patients with monogenic diabetes due to pathogenic variants in GCK and HNF1A genes

Frontiers in Endocrinology
BackgroundWhile treatment algorithms for the most common forms of monogenic diabetes (MD) are well established, managing affected pregnancies remains a clinical challenge.
Magdalena Szopa, Magdalena Szopa, Karolina Zawadzka, Michał Kania, Michał Kania, Przemysław Witek, Przemysław Witek, Katarzyna Cyganek, Katarzyna Cyganek   +8 more
doaj   +1 more source

Dietary Artificial Sweeteners: From Chemical Transformation in Food to Gut Microbial Processing

ChemFoodChem, EarlyView.
This review article unites classical and recent findings on the stability of artificial sweeteners in food. The focus is on ten sweeteners approved in the European Union: their chemical stability during processing and storage, individual degradation products, and their interactions with the intestinal microbiota.
Jürgen Lassak, Michael Hellwig
wiley   +1 more source

Maturity Onset Diabetes of the Young (MODY): French National Diagnosis and Care Protocol (PNDS, Protocole National de Diagnostic et de Soins)

Orphanet Journal of Rare Diseases
MODY (Maturity-Onset Diabetes of the Young) is characterized by autosomal dominant mode of inheritance, early onset of diabetes in the absence of autoimmunity directed to pancreatic β-cells, impaired insulin secretory capacity, however, maintained over ...
Danièle Dubois-Laforgue, Bruno Donadille, Cécile Ciangura , Chloé Amouyal, Jean-Baptiste Arnoux, Pascal Barat, Sabine Baron, Jacques Beltrand, Elise Bismuth, Clara Bouché, Jean-Claude Carel, Hélène Cavé, Sophie Christin-Maitre, Delphine Collin-Chavagnac, Christiane Damgé, Brigitte Delemer, Pierre Gourdy , Sophie Jacqueminet, Sonja Janmaat , Marc de Kerdanet, Laurence Kessler, Dominique Langin , Jean-Charles Nault, Jacky Nizard, Michel Polak , Rachel Reynaud, Cécile Saint-Martin, Igor Tauveron, René Valéro, Anne Vambergue, Marie-Christine Vantyghem, Camille Vatier, Marc Nicolino, Christine Bellanné-Chantelot, Corinne Vigouroux   +34 more
doaj   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Diabetic vascular disease and Maturity-onset diabetes of the young

, 2016
Aim: Vascular disease such as cardiovascular and cerebrovascular diseases, or retinopathy, nephropathy and neuropathy are common in diabetes.
Mafra, J.M., Bourbon, Mafalda, Gaspar, G.   +2 more
core  

Clinical and genetic characteristics of maturity‐onset diabetes of the young type 13: A systematic review of the literature

Objective Maturity‐onset diabetes of the young type 13 (MODY13), a rare type of monogenic diabetes, is often misdiagnosed as type 1 or type 2 diabetes. To improve early diagnosis and precise treatment, we performed a systematic review and analysis of the
Mingwei Zhao, Xiaodong Hu, Yaning Chen
core   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Maturity onset diabetes of the young in pregnancy: diagnosis, management and prognosis of MODY in pregnancy

, 2017
Current management guidelines of diabetes within pregnancy do not differentiate between the underlying physiological dysfunctions that lead to dysglycaemia and provide generic guidance.
Dharmintra Pasupathy, Anita Banerjee, Reed, A., A. Reed, Rees, Kate, Pasupathy, Dharmintra, Kate Rees, Banerjee, Anita   +7 more
core   +1 more source