Results 121 to 130 of about 19,208 (245)

Model-based prediction of human hair color using DNA variants [PDF]

, 2011
Predicting complex human phenotypes from genotypes is the central concept of widely advocated personalized medicine, but so far has rarely led to high accuracies limiting practical applications.
Branicki, W. (Wojciech), Draus-Barini, J. (Jolanta), Duijn, K. (Kate) van, Kayser, M.H. (Manfred), Kupiec, T. (Tomasz), Liu, F. (Fan), Pośpiech, E. (Ewelina), Walsh, S. (Susan), Wojas-Pelc, A. (Anna)   +8 more
core   +5 more sources

A Genomic Exploration of the Possible De‐Extirpation of the Zanzibar Leopard

Molecular Ecology, Volume 34, Issue 23, December 2025.
ABSTRACT The recently extirpated Zanzibar leopard was the only known African leopard (Panthera pardus spp.) population restricted exclusively to a major island habitat. Although its demise was driven through habitat change and conflict with humans, given its role as a keystone species for the Zanzibar Archipelago, its successful potential ...
Xin Sun, Emily Louisa Cavill, Ashot Margaryan, Jianqing Lin, Søren Thingaard, Tamrini A. Said, Shyam Gopalakrishnan, M. Thomas P. Gilbert   +7 more
wiley   +1 more source

CDKN2A and MC1R analysis in amelanotic and pigmented melanoma

Melanoma Research, 2009
Amelanotic melanoma (AM) is a rare subtype of melanoma with little or no clinically visible pigment; it is more difficult to diagnose than pigmented melanoma (PM), and has a worse prognosis. In the attempt to find a genetic explanation for the distinction between AM and PM, we conducted a case-case study, matching AM and PM patients, and testing them ...
GHIORZO, PAOLA, PASTORINO, LORENZA, Pizzichetta MA, Bono R, Queirolo P, Talamini R, Annessi G, BRUNO, WILLIAM, NASTI, SABINA, GARGIULO, SARA, BATTISTUZZI, LINDA, Sini MC, Palmieri G, BIANCHI, GIOVANNA, Italian Melanoma Intergroup   +14 more
openaire   +6 more sources

Construction of MC1R and ASIP Eukaryotic Expression Vector and its Regulation of Plumage Color in Japanese Quail (Coturnix japonica)

The Journal of Poultry Science, 2019
The Japanese quail expresses polymorphism in plumage colors, including black, yellow, white, wild-type (maroon), and various intermediate colors through hybridization of quail with different plumage colors.
Yi-xin Li, Xiao-hui Zhang, You-zhi Pang, Yan-xia Qi, Shu-juan Zhao   +4 more
doaj   +1 more source

Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genes [PDF]

, 2011
Massese is an Italian dairy sheep breed characterized by animals with black skin and horns and black or apparent grey hairs. Owing to the presence of these two coat colour types, this breed can be considered an interesting model to evaluate the effects
Beretti, F, Dall’Olio, S, Fontanesi, L, PORTOLANO, Baldassare, Russo, V.   +4 more
core   +1 more source

Identifying the Degree of Gene Reuse During Repeated Adaptation

Molecular Ecology, Volume 34, Issue 24, December 2025.
ABSTRACT The degree or extent of gene reuse during repeated adaptation offers key insights into the genomic constraints on evolution. Although many studies have identified signs of genomic repeatability, a thorough synthesis of methods for detecting gene reuse and estimating its extent is missing. In this review, we first propose a simple framework for
Samridhi Chaturvedi, Lakshmi Vineesha Digumarthi, Garima Setia   +2 more
wiley   +1 more source

Analysis of Genetic Basis of the Red Coat Colour of Crossbred of Duroc and Ding'an Pig

Guangdong nongye kexue
【Objective】The melanocortin 1 receptor (MC1R) plays a critical role in mammalian pigmentation and coat color formation. Different MC1R alleles are associated with various coat color patterns in pigs.
Sitong ZHU, Jiangtao ZHOU, Yaosheng CHEN, Peiqing CONG, Su WU, Xiaohong LIU, Zuyong HE   +6 more
doaj   +1 more source

Hierarchical modeling of melanocortin 1 receptor variants with skin cancer risk [PDF]

, 2018
The human MC1R gene is highly polymorphic among lightly pigmented populations, and several variants in the MC1R gene have been associated with increased risk of both melanoma and nonmelanoma skin cancers. The functional consequences of MC1R gene variants
Han, Jiali, Joshi, Amit D., Kraft, Peter, Li, Xin   +3 more
core   +1 more source

Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care

Pediatric Anesthesia, Volume 35, Issue 12, Page 1053-1062, December 2025.
ABSTRACT Background Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, double‐blind, randomized, active‐controlled noninferiority trial with a 1:1 randomization between clonidine ...
Maddlie Bardol, Yucheng Sheng, Manuel Baarslag, Adriana Ceci, Frank Dörje, Mari‐Liis Ilmoja, Peter Larsson, Per‐Arne Lönnqvist, Tuuli Methsvat, Pavla Pokorna, Wolfgang Rascher, Joost van Rosmalen, Michael Schroth, Alessandra Simonetti, Dick Tibboel, Irmgard Toni, Catherine Tuleu, Thomas M. K. Völkl, Brian J. Anderson, Stefan Wimmer, Joseph F. Standing, Antje Neubert, CloSed Consortium   +22 more
wiley   +1 more source

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source