Results 71 to 80 of about 4,530 (193)

Contrasting effects of leptin on food anticipatory and total locomotor activity. [PDF]

PLoS ONE, 2011
Obese, leptin deficient obob mice have profoundly decreased activity and increased food seeking behavior. The decreased activity has been attributed to obesity. In mice, we tested the hypothesis that leptin increases total locomotor activity but inhibits
Ana C Ribeiro, Giovanni Ceccarini, Christophe Dupré, Jeffrey M Friedman, Donald W Pfaff, Allyn L Mark   +5 more
doaj   +1 more source

A receptor-based analysis of local ecosystems in the human brain. [PDF]

, 2017
BackgroundAs a complex system, the brain is a self-organizing entity that depends on local interactions among cells. Its regions (anatomically defined nuclei and areas) can be conceptualized as cellular ecosystems, but the similarity of their functional ...
Janušonis, Skirmantas
core   +1 more source

The role of accessory proteins and co‐factors in regulation of melanocortin‐4 receptor signalling: An update

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The melanocortin‐4 receptor (MC4R) is a G protein‐coupled receptor with an essential role in appetite suppression and energy homeostasis. Genetic mutations in the receptor and components of its signalling pathway that cause obesity in humans, dogs and rodent models have revealed important insights into how the receptor signals and what ...
Aqfan Jamaluddin, Alyce McClellan, Eleanor Raffan, Caroline M. Gorvin   +3 more
wiley   +1 more source

Agouti-related protein as the glucose signaling sensor in the central melanocortin circuits in regulating fish food intake

Frontiers in Endocrinology, 2022
Agouti-related protein (AgRP) is a neuropeptide synthesized by AgRP/NPY neurons and transcribed as 132 amino acids in humans and 142 amino acids (AgRP1) in Japanese seabass (Lateolabrax maculatus) fish.
Juan Han, Xiaofang Liang, Yanzhi Guo, Xiaoliang Wu, Ziqi Li, Tiannuo Hong   +5 more
doaj   +1 more source

A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make [PDF]

, 2017
Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder with early-onset obesity. Investigation of this entity have increased our insight into the important role of the leptin-melanocortin pathway in energy balance. Here, we present a patient
Achermann, JC, Aycan, Z, Buonocore, F, Cetinkaya, S, Erdeve, SS, Guran, T, Keskin, M, Kurnaz, E, Sagsak, E, Suntharalingham, JP   +9 more
core   +2 more sources

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

Obesity, Volume 34, Issue 2, Page 499-511, February 2026.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli, Chrisitne Poitou, Mathieu Georget, Françoise Bertin, Ahlam Azar‐Kolakez, Claire Carette, Pauline Faucher, Blandine Gatta‐Cherifi, Julie Gonneau‐Lejeune, Agnès Linglart, Karine Clément, Johanne Le Beyec‐Le Bihan, Béatrice Dubern   +12 more
wiley   +1 more source

Association analysis of seven candidate genes with performance traits in Czech Large White pigs

Czech Journal of Animal Science, 2011
In this study association analyses were performed between genes tagged SNP (IGF2, NAMPT, DGAT1, MYF4, MC3R, MC4R and MYOD1), performance traits (backfat thickness, lean meat content, average daily gain from birth to the end of the test, average daily ...
F. Weisz, T. Urban, P. Chalupová, A. Knoll   +3 more
doaj   +1 more source

Explore the Protective Role of Obesity in the Progression of Myocardial Infarction

Frontiers in Cardiovascular Medicine, 2021
Obesity has been shown as a risk factor to increase the incidence of myocardial infarction (MI). However, obesity has also been linked to the decreased mortality of acute MI with unknown mechanisms.
Siyuan Zhao, Rongyuan Cao, Shuhua Zhang, Yan Kang   +3 more
doaj   +1 more source

Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs [PDF]

, 2016
BACKGROUND: DNA methylation levels will be important for detection of epigenetic effects. However, there are few reports showing sex-related differences in the sensitivity to DNA methylation.
Chika Honda, Chika Honda, Hiroko Watanabe, Hiroyasu Iso, Jun Hatazawa, Kei Kamide, Kiyoko Makimoto, Mikio Watanabe, Mikio Watanabe, Norio Sakai, null null, Shinji Kihara, Shiro Yorifuji, Yoshinori Iwatani, Yoshinori Iwatani   +14 more
core   +1 more source

Neuroendocrine plasticity and crosstalk in pubertal development

Journal of Neuroendocrinology, Volume 38, Issue 2, February 2026.
Abstract Puberty is a critical developmental stage during which individuals acquire the capacity for sexual reproduction. This transition involves a series of complex biological events primarily orchestrated by the activation of the hypothalamo–pituitary–gonadal (HPG) axis.
Carol Fuzeti Elias, Xingfa Han, David Garcia‐Galiano, Cristina Sáenz de Miera   +3 more
wiley   +1 more source